Brain-gut peptides, renal function and cell growth

Unwin, Robert J.; Ganz, Melanie; Sterzel, R.B.

doi:10.1038/ki.1990.83

Cited by 18 publications

(12 citation statements)

References 213 publications

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“…In our study desmopressin had no effect on ileal volume or composition, suggesting that any inhibitory effect of native arginine vasopressin may be secondary to its vasoconstrictive action or, like its V1IV3 receptor renal effect, may be due to local release of other mediators such as prostanoids' or neuropeptides. 38 The phenomenon of 'low sodium' diuresis may be an important contributing factor to salt and water depletion in patients with ileostomies. While reversing the diuresis of sodium restriction, the V2 agonist desmopressin does not affect renal sodium excretion or ileal loss.…”

Section: Discussionmentioning

confidence: 99%

'Low sodium' diuresis and ileal loss in patients with ileostomies: effect of desmopressin.

Sutters

Carmichael²,

Unwin³

et al. 1991

Gut

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Patients with ileostomies show an early diuresis when sodium restricted; this, together with an obligatory ileal sodium loss, predisposes them to severe salt and water depletion. The role of arginine vasopressin in this circumstance and whether it is natriuretic, or antinatriuretic, is unclear. There is also controversy over its likely effect on smali bowel fluid reabsorption. We have examined the effect of the non-pressor (V,) synthetic vasopressin analogue 1-deamino-8-D-arginine (desmopressin) on renal and ileal sodium and water excretion in ileostomy patients during acute adaptation to a low sodium diet. Patients were studied on two separate occasions (nonrandomised) with and without the administration of desmopressin (0.75 [ig intramuscular, three times a day). In eight subjects without desmopressin there was pronounced diuresis on the first low sodium day, associated with a fall in renal sodium excretion and no change in ileal output or composition. In five (of the original) subjects with desmopressin there was pronounced antidiuresis, no change in renal sodium excretion, and no change in ileal output or composition. In both studies rises in plasma renin activity and salivary aldosterone concentration lagged behind the early decline in renal sodium excretion. We have confirmed the phenomenon of 'low sodium' diuresis after sodium restriction in ileostomy patients and shown that it can be prevented by desmopressin. Desmopressin has no direct or indirect effect on renal sodium excretion or ileal fluid and electrolyte loss in humans.

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Section: Discussionmentioning

confidence: 99%

'Low sodium' diuresis and ileal loss in patients with ileostomies: effect of desmopressin.

Sutters

Carmichael²,

Unwin³

et al. 1991

Gut

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“…Abnormal fluid regulation has also been described in mice lacking VIP or PACAP (40,42,43), so it will be of interest to establish if PDF signaling has related in vivo roles in flies. The presence of VIP/PACAP immunoreactivity in neural fibers of the lower urinary tract of mammals suggests a local, transmitter-like action on the excretory muscle receptors (12), and VIP is generally believed to act as a local neurotransmitter rather than as a circulating hormone (44,45). However, systemic effects of gut-derived VIP cannot be ruled out.…”

Section: (D and E) Pdfr Expression In Adult Oregon-r Ureters (Arrows)mentioning

confidence: 91%

Remote control of renal physiology by the intestinal neuropeptide pigment-dispersing factor in Drosophila

Talsma

Christov

Terriente‐Felix

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

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The role of the central neuropeptide pigment-dispersing factor (PDF) in circadian timekeeping in Drosophila is remarkably similar to that of vasoactive intestinal peptide (VIP) in mammals. Like VIP, PDF is expressed outside the circadian network by neurons innervating the gut, but the function and mode of action of this PDF have not been characterized. Here we investigate the visceral roles of PDF by adapting cellular and physiological methods to the study of visceral responses to PDF signaling in wild-type and mutant genetic backgrounds. We find that intestinal PDF acts at a distance on the renal system, where it regulates ureter contractions. We show that PdfR, PDF's established receptor, is expressed by the muscles of the excretory system, and present evidence that PdfR-induced cAMP increases underlie the myotropic effects of PDF. These findings extend the similarities between PDF and VIP beyond their shared central role as circadian regulators, and uncover an unexpected endocrine mode of myotropic action for an intestinal neuropeptide on the renal system. intestine | tubule | enteric | nervous system

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“…It is interesting to note that previous studies suggested an effect of CCK-related peptides in the kidney. Specifically, it has been shown that CCK-8, which interacts with CCK B receptors with high affinity, is able to cause changes in the glomerular filtration rate and in the renal blood flow in rabbit or man (Calam et al 1987;Duggan et al 1988;Unwin et al 1990). Studies using free-flow renal micropuncture in rats revealed that CCK-8 directly inhibits sodium and water transport in the loop of Henle (Unwin et al 1988).…”

Section: Discussionmentioning

confidence: 99%

Evidence for CCKB receptors in the guinea-pig kidney: localization and characterization by [125I]gastrin binding studies and by RT-PCR

Schrenck

Weerth

et al. 1998

Naunyn-Schmiedeberg's Arch Pharmacol

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Two types of receptors for gastrin and cholecystokinin (CCK) have been identified in the gastrointestinal tract and in the central nervous system: CCK(A) and CCK(B) receptors. Here we report evidence for the expression of CCK(B) receptors in the guinea-pig kidney. Specific binding sites for [125I]gastrin were detected in sections of the guinea-pig kidney: Binding was saturable, pH-, temperature- and time-dependent, and specific for gastrin-related peptides. The potencies for inhibition of binding of [125I]gastrin were CCK-8 > gastrin 17-I > CCK(B) receptor antagonist L-365,260 > des(SO3)CCK-8 > CCK(A) receptor antagonist L-364,718. Autoradiography demonstrated specific [125I]gastrin binding to medullary collecting ducts and to a much lesser extent to glomeruli, but not over other structures. CCK(B) receptor cDNA fragments were amplified by RT-PCR from total kidney, isolated tubuli and from tissues known to express CCK(B) receptors such as stomach and brain. The kidney might therefore be a previously unidentified site of action for gastrin and cholecystokinin-related peptides.

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Brain-gut peptides, renal function and cell growth

Cited by 18 publications

References 213 publications

'Low sodium' diuresis and ileal loss in patients with ileostomies: effect of desmopressin.

'Low sodium' diuresis and ileal loss in patients with ileostomies: effect of desmopressin.

Remote control of renal physiology by the intestinal neuropeptide pigment-dispersing factor in Drosophila

Evidence for CCKB receptors in the guinea-pig kidney: localization and characterization by [125I]gastrin binding studies and by RT-PCR

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