Brain gray matter alterations in first episodes of depression: A meta-analysis of whole-brain studies

Zhang, Huawei; Li, Lei; Wu, Min; Chen, Ziqi; Hu, Xinyu; Chen, Ying; Zhu, Hongyan; Jia, Zhiyun; Gong, Qiyong

doi:10.1016/j.neubiorev.2015.10.011

Cited by 134 publications

(107 citation statements)

References 62 publications

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“…A probabilistic tractography study reported that the areas with shape deformities in the bilateral putamen and left thalamus had connections with the frontal and temporal lobes . The gray matter volume of the right thalamus was also found to be reduced in MDD patients, and this finding was confirmed by a recent meta‐analysis . As some studies have shown, drugs and acute attacks can affect the volume of the thalamus, which may suggest a state‐dependent manner of depression .…”

Section: Significant Structural Brain Alterations In Mddmentioning

confidence: 72%

Brain structure alterations in depression: Psychoradiological evidence

et al. 2018

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Depression is the leading cause of disability around the world, but little is known about its pathology. Currently, the diagnosis of depression is made based on clinical manifestations, with little objective evidence. Magnetic resonance imaging (MRI) has been used to investigate the pathological changes in brain anatomy associated with this disorder. MRI can identify structural alterations in depressive patients in vivo, which could make considerable contributions to clinical diagnosis and treatment. Numerous studies that focused on gray and white matter have found significant brain region alterations in major depressive disorder patients, such as in the frontal lobe, hippocampus, temporal lobe, thalamus, striatum, and amygdala. The results are inconsistent and controversial because of the different demographic and clinical characteristics. However, some regions overlapped; thus, we think that there may be a "hub" in MDD and that an impairment in these regions contributes to disease severity. Brain connections contain both structural connections and functional connections, which reflect disease from a different view and support that MDD may be caused by the interaction of multiple brain regions. According to previous reports, significant circuits include the frontal-subcortical circuit, the suicide circuit, and the reward circuit. As has been recognized, the pathophysiology of major depressive disorder is complex and changeable. The current review focuses on the significant alterations in the gray and white matter of patients with the depressive disorder to generate a better understanding of the circuits. Moreover, identifying the nuances of depressive disorder and finding a biomarker will make a significant contribution to the guidance of clinical diagnosis and treatment.

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Section: Significant Structural Brain Alterations In Mddmentioning

confidence: 72%

Brain structure alterations in depression: Psychoradiological evidence

et al. 2018

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“…Its activation, which has been conceptualized as preventing small stressors from becoming big stressors, may be especially relevant to the left PFC deficits seen in depressions, where small stressors indeed become overwhelming 20 . Recently, a meta-analysis also identified decreased GMV in PFC in depressions 21 . Abnormalities in the function, structure 22 , and brain circuit related to this region 23 were all reported to be involved in emotion regulation 24 .…”

Section: Discussionmentioning

confidence: 99%

Sex differences in the clinical characteristics and brain gray matter volume alterations in unmedicated patients with major depressive disorder

Yang

Peng

et al. 2017

Sci Rep

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This study was to explore the sex differences in clinical characteristics and brain gray matter volume (GMV) alterations in 29 male patients with major depressive disorder (MDDm), 53 female patients with MDD (MDDf), and in 29 male and 53 female matched healthy controls. Maps of GMV were constructed using magnetic resonance imaging data and compared between groups. We evaluated clinical symptoms using the Hamilton Rating Scale for Depression and obtained a total score and five syndrome scores. A two-factor ANCOVA model was specified using SPM8, with sex and diagnosis as the between-subject factors. We found that: (1) significant GMV increase in the left cerebellum and GMV reduction in the bilateral middle temporal gyrus and left ventral medial prefrontal gyrus occurred selectively in male patients, while the GMV reduction in the left lingual gyrus and dorsal medial prefrontal gyrus occurred selectively in female patients; (2) MDDf may have experienced more severe sleep disturbance than MDDm; and (3) the severity of sleep symptom could be predicted by the sex specific brain structural alterations in depressions. These findings suggest that sex specific anatomical alterations existed in MDD, and these alterations were associated with the clinical symptoms.

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“…For example, a recent transcranial magnetic stimulation study found that repetitive stimulation to the SMA increased the perceived valence of negative emotional stimuli in healthy individuals (Rodigari & Oliveri, ). Neuroimaging research has revealed abnormal structure and function of SMA in depression (Liu et al, ; Zhang et al, ). Thus, dysfunction of SMA may contribute to enhanced negative emotions in MDD, including related to oneself.…”

Section: Discussionmentioning

confidence: 99%

Neural and behavioral correlates of negative self‐focused thought associated with depression

Philippi

Cornejo

Frost

et al. 2018

Human Brain Mapping

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A central feature of major depression (MDD) is heightened negative self-focused thought (negative-SFT). Neuroscientific research has identified abnormalities in a network of brain regions in MDD, including brain areas associated with SFT such as medial prefrontal cortex (mPFC) and anterior cingulate cortex (ACC). To our knowledge no studies have investigated the behavioral and neural correlates of negative-SFT using a sentence completion task in a sample of individuals with varying depression histories and severities. We test the following hypotheses: (1) negative-SFT will be associated with depression; and (2) depression and negative-SFT will be related to resting-state functional connectivity (rsFC) for brain regions implicated in SFT. Seventy-nine women with varying depression histories and severities completed a sentence completion task and underwent resting-state functional magnetic resonance imaging (rs-fMRI). Standard seed-based voxelwise rsFC was conducted for self-network regions of interest: dorsomedial PFC (dmPFC) and pregenual ACC (pgACC). We performed linear regression analyses to examine the relationships among depression, negative-SFT, and rsFC for the dmPFC and pgACC. Greater negative-SFT was associated with depression history and severity. Greater negative-SFT predicted increased rsFC between dmPFC and pgACC seeds and dorsolateral prefrontal (dlPFC) and parietal regions; depression group was also associated with increased pgACC-dlPFC connectivity. These findings are consistent with previous literature reporting elevated negative-SFT thought in MDD. Our rs-fMRI results provide novel support linking negative-SFT with increased rsFC between self-network and frontoparietal network regions across different levels of depression. Broadly, these findings highlight a dimension of social-affective functioning that may underlie MDD and other psychiatric conditions.

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Brain gray matter alterations in first episodes of depression: A meta-analysis of whole-brain studies

Cited by 134 publications

References 62 publications

Brain structure alterations in depression: Psychoradiological evidence

Brain structure alterations in depression: Psychoradiological evidence

Sex differences in the clinical characteristics and brain gray matter volume alterations in unmedicated patients with major depressive disorder

Neural and behavioral correlates of negative self‐focused thought associated with depression

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