Brain gene delivery using histidine and arginine-modified dendrimers for ischemic stroke therapy

Lee, Mi Kyung; Lee, Jeil; Kim, Minkyung; Kim, Gyeungyun; Choi, Ji Soo; Lee, Minhyung

doi:10.1016/j.jconrel.2020.10.064

Cited by 45 publications

(35 citation statements)

References 40 publications

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“…Each amino acid has different functions in the gene delivery process; therefore, gene transfection efficacy depends on the conjugation ratio and the type of amino acid 128,130 . The cargo is delivered to the target cells mainly through clathrin‐independent endocytosis and, in some cases, micropinocytosis 131 11 129 …”

Section: Histidine‐based Polymersmentioning

confidence: 99%

“…Different generations of dendrimer‐based nanosystems have been investigated for the treatment of cancer, myocardial infarction and ischemic stroke. Lee et al 131 . designed and fabricated a PAMAM generation 2 dendrimer conjugated with histidine and arginine (PG2HR) as a nanostructure to deliver a heme oxygenase‐1 (HO‐1) plasmid for treatment of ischemic stroke, as a result of its anti‐inflammatory and anti‐apoptotic properties (Figure 12).…”

Section: Histidine‐based Polymersmentioning

confidence: 99%

“…129 clathrin-independent endocytosis and, in some cases, micropinocytosis. 131 The structure of histidine grafted PAMAM G4.0 is shown in Figure 11. 129 Wang et al 130 reported that the modification of dendrimers with His residues facilitated the endosomal escape of the polyplex, and achieved relatively high transfection efficacy as well as low cytotoxicity in the HEK293 cell line.…”

Section: Histidine-modified Branched Polymersmentioning

confidence: 99%

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Histidine‐enhanced gene delivery systems: The state of the art

Hooshmand

Sabet

Hasanzadeh

et al. 2022

The Journal of Gene Medicine

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Gene therapy has emerged as a promising tool for treating different intractable diseases, particularly cancer or even viral diseases such as COVID-19 (coronavirus disease 2019). In this context, various non-viral gene carriers are being explored to transfer DNA or RNA sequences into target cells. Here, we review the applications of the naturally occurring amino acid histidine in the delivery of nucleic acids into cells.The biocompatibility of histidine-enhanced gene delivery systems has encouraged their wider use in gene therapy. Histidine-based gene carriers can involve the modification of peptides, dendrimers, lipids or nanocomposites. Several linear polymers, such as polyethylenimine, poly-L-lysine (synthetic) or dextran and chitosan (natural), have been conjugated with histidine residues to form complexes with nucleic acids for intracellular delivery. The challenges, opportunities and future research trends of histidine-based gene deliveries are investigated.

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Section: Histidine‐based Polymersmentioning

confidence: 99%

Section: Histidine‐based Polymersmentioning

confidence: 99%

Section: Histidine-modified Branched Polymersmentioning

confidence: 99%

See 1 more Smart Citation

Histidine‐enhanced gene delivery systems: The state of the art

Hooshmand

Sabet

Hasanzadeh

et al. 2022

The Journal of Gene Medicine

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“…The authors suggested that the protective factor can be related to a higher expression and levels of HO-1 associated with greater antioxidative effects [151]. The protective effects of higher HO-1 expression were proven in endothelial cell culture exposed to intermittent hypoxia [150] (as a model of OSA) and experimental stroke models with gene modulation [152] and included the suppression of cytotoxicity, cell apoptosis, and inflammation [153], and reduction in brain lesion volume [154][155][156].…”

Section: Sleep Disorders and Risk Of Strokementioning

confidence: 99%

“…Gene therapy is a promising approach and is being investigated in stroke models. Modulation of HO-1 gene has a neuroprotective effect in mice model of ischemic stroke [152] and is associated with the reduction of infarct volume [154][155][156].…”

Section: Gene Modulation In Stroke: Evidence and Prospectsmentioning

confidence: 99%

Ischemic Stroke and Sleep: The Linking Genetic Factors

Korostovtseva

2021

Cardiol Ther

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This review summarizes the available data about genetic factors which can link ischemic stroke and sleep. Sleep patterns (subjective and objective measures) are characterized by heritability and comprise up to 38-46%. According to Mendelian randomization analysis, genetic liability for short sleep duration and frequent insomnia symptoms is associated with ischemic stroke (predominantly of large artery subtype). The potential genetic links include variants of circadian genes, genes encoding components of neurotransmitter systems, common cardiovascular risk factors, as well as specific genetic factors related to certain sleep disorders.

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