Brain Functional Alteration at Different Stages of Neuropathic Pain With Allodynia and Emotional Disorders

Zhang, Yanan; Xing, Xiang‐Xin; Chen, Liu; Dong, Xin; Pan, Hongqiu; Hua, Xu‐Yun; Wang, Ke

doi:10.3389/fneur.2022.843815

Cited by 2 publications

(1 citation statement)

References 66 publications

(67 reference statements)

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“…In contrast to previous resting-state fMRI investigations that concentrated on regional functional measurements, i.e., ReHo ( Li et al, 2023 ), ALFF ( Liu et al, 2020 ; Li et al, 2023 ), ICA ( Li et al, 2022 ; Chen et al, 2023 ), seed-based FC ( Wang et al, 2023 ), and large-scale brain network analysis ( Zhang et al, 2023 ), the index of voxel-wise DC can highlight the influence and significance of a given network at the voxel level and indicate the hub features of the functional brain network. This method has been extensively applied to survey DC abnormalities in relation to conditions such as trigeminal neuralgia ( Liu et al, 2022 ; Ge et al, 2023 ), migraine ( Zhang et al, 2017 ; Lee et al, 2019 ), and neuropathic pain ( Zhang et al, 2022 ). However, the presence of DC abnormalities in patients with VM remains to be determined.…”

Section: Introductionmentioning

confidence: 99%

Brain functional connectivity patterns associated with symptoms of vestibular migraine

Zhe,

Zhang,

Tang

et al. 2023

Front. Neurosci.

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BackgroundSeveral functional magnetic resonance imaging (fMRI) investigations of patients with vestibular migraine (VM) have revealed abnormal functionality in different networks, indicating that VM is related to alterations in brain function. We sought to investigate the resting-state functional connectivity (FC) patterns during the interictal period in VM by combining data-driven voxel-wise degree centrality (DC) calculations and seed-based FC analyses, and thereby determine the associations between cerebral function and clinical symptoms.MethodsThirty-eight patients with VM and 33 matched normal controls were recruited. DC was calculated and compared between the groups, and the FC of locations showing DC alterations was further tested using a seed-based technique. The participants’ clinical indicators were correlated with the DC and FC values of the brain areas.ResultsIn contrast to the control group, the VM group showed considerably lower DC values in the bilateral medial prefrontal cortex (mPFC) and significantly higher DC values in the right occipital lobe. In the seed-based FC analyses, patients with VM demonstrated fewer connections of the bilateral mPFC with the bilateral posterior cingulate cortex, right parahippocampus, right cerebellar posterior lobe, bilateral cuneus, and left precuneus. In addition, clinical data from patients, such as pain intensity, episode frequency, and the Dizziness Handicap Inventory score, were negatively related to these FC and DC impairments.ConclusionOur findings showed changes in the default mode network and visual cortex in patients with VM, providing further insights into the complexity of the mechanisms underlying VM.

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Section: Introductionmentioning

confidence: 99%

Brain functional connectivity patterns associated with symptoms of vestibular migraine

Zhe,

Zhang,

Tang

et al. 2023

Front. Neurosci.

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Metabotropic Glutamate Receptor 5 in the Dysgranular Zone of Primary Somatosensory Cortex Mediates Neuropathic Pain in Rats

et al. 2022

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The primary somatosensory cortex (S1) plays a key role in the discrimination of somatic sensations. Among subdivisions in S1, the dysgranular zone of rodent S1 (S1DZ) is homologous to Brodmann’s area 3a of primate S1, which is involved in the processing of noxious signals from the body. However, molecular changes in this region and their role in the pathological pain state have never been studied. In this study, we identified molecular alteration of the S1DZ in a rat model of neuropathic pain induced by right L5 spinal nerve ligation (SNL) surgery and investigated its functional role in pain symptoms. Brain images acquired from SNL group and control group in our previous study were analyzed, and behaviors were measured using the von Frey test, acetone test, and conditioned place preference test. We found that metabotropic glutamate receptor 5 (mGluR5) levels were significantly upregulated in the S1DZ contralateral to the nerve injury in the SNL group compared to the sham group. Pharmacological deactivation of mGluR5 in S1DZ ameliorated symptoms of neuropathic allodynia, which was shown by a significant increase in the mechanical paw withdrawal threshold and a decrease in the behavioral response to cold stimuli. We further confirmed that this treatment induced relief from the tonic-aversive state of chronic neuropathic pain, as a place preference memory associated with the treatment-paired chamber was formed in rats with neuropathic pain. Our data provide evidence that mGluR5 in the S1DZ is involved in the manifestation of abnormal pain sensations in the neuropathic pain state.

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Brain Functional Alteration at Different Stages of Neuropathic Pain With Allodynia and Emotional Disorders

Abstract: Graphical AbstractBrain functional alteration at different stages of neuropathic pain.

Cited by 2 publications

References 66 publications

Brain functional connectivity patterns associated with symptoms of vestibular migraine

Brain functional connectivity patterns associated with symptoms of vestibular migraine

Metabotropic Glutamate Receptor 5 in the Dysgranular Zone of Primary Somatosensory Cortex Mediates Neuropathic Pain in Rats

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