Brain Function and Upper Limb Deficit in Stroke With Motor Execution and Imagery: A Cross-Sectional Functional Magnetic Resonance Imaging Study

Ma, Zhen‐Zhen; Wu, Jiajia; Hua, Xu‐Yun; Zheng, Mou‐Xiong; Xing, Xiang‐Xin; Ma, Jie; Li, Sisi; Shan, Chunlei; Xu, Jian-Guang

doi:10.3389/fnins.2022.806406

Cited by 13 publications

(8 citation statements)

References 51 publications

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“…There are several potential reasons for this. First, the small variance in cognitive outcome was due to the fact that, in order to comply with the current research, poststroke patients were required to score above 22 in the MMSE (Brodtmann et al, 2020; Ma et al, 2022). Second, inherent properties of the clinical assessment may result in a small variance.…”

Section: Discussionmentioning

confidence: 99%

Morphological alterations of contralesional hemisphere relate to functional outcomes after stroke

Lu,

Xing,

et al. 2023

Eur J of Neuroscience

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The present study aimed to investigate poststroke morphological alterations contralesionally and correlations with functional outcomes. Structural magnetic resonance images were obtained from 27 poststroke patients (24 males, 50.21 ± 10.97 years) and 20 healthy controls (13 males, 46.63 ± 12.18 years). Voxel‐based and surface‐based morphometry analysis were conducted to detect alterations of contralesional grey matter volume (GMV), cortical thickness (CT), gyrification index (GI), sulcus depth (SD), and fractal dimension (FD) in poststroke patients. Partial correlation analysis was used to explore the relationship between regions with significant structural differences and scores of clinical assessments, including Modified Barthel Index (MBI), Berg Balance Scale (BBS), Fugl–Meyer Assessment of Upper Extremity (FMA‐UE), Mini‐Mental State Examination (MMSE), and Montreal Cognitive Assessment (MoCA). Correction for multiplicity was conducted within each parameter and for all tests. GMV significantly decreased in the contralesional motor‐related, occipital and temporal cortex, limbic system, and cerebellum lobe (P < 0.01, family‐wise error [FWE] correction). Lower CT was found in the contralesional precentral and lingual gyrus (P < 0.01, FWE correction), while lower GI found in the contralesional superior temporal gyrus and insula (P < 0.01, FWE correction). There were significant correlations between GMV of contralesional lingual gyrus and MBI (P = 0.031, r = 0.441), and BBS (P = 0.047, r = 0.409) scores, and GMV of contralesional hippocampus and FMA‐UE scores (P = 0.048, r = 0.408). In conclusion, stroke patients exhibited wide grey matter loss and cortical morphological changes in the contralesional hemisphere, which correlated with sensorimotor functions and the ability of daily living.

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Section: Discussionmentioning

confidence: 99%

Morphological alterations of contralesional hemisphere relate to functional outcomes after stroke

Lu,

Xing,

et al. 2023

Eur J of Neuroscience

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“…The abovementioned studies focused on gait and balance treatment, whereas we trained the upper limbs exclusively. In contrast to gait [ 50 , 51 , 52 ], during upper limb movements, prevalent cerebral activation occurs in the cortical areas (i.e., sensorimotor cortex, supplementary motor area, premotor cortex, inferior frontal gyrus and ipsilateral anterior cingulate) both in neurological patients and healthy controls [ 53 , 54 ]. Motor exercise may increase the production of growth factors and promote gray and white matter changes, especially in the prefrontal region, with a particular effect on executive functions [ 55 , 56 , 57 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Upper Limb Motor Rehabilitation on Cognition in Parkinson’s Disease: An Observational Study

et al. 2022

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Parkinson’s disease is characterized by motor and cognitive deficits that usually have an impact on quality of life and independence. To reduce impairment, various rehabilitation programs have been proposed, but their effects on both cognitive and motor aspects have not been systematically investigated. Furthermore, most intervention is focused on lower limb treatment rather than upper limbs. In the present study, we investigated the effect of 3-week upper limb vibratory stimulation training on cognitive functioning in 20 individuals with Parkinson’s disease. We analyzed cognitive (Montreal Cognitive Assessment, Trial Making Test, Digit Symbol, Digit Span Forward and Backward and Alertness) and motor performance (Unified Parkinson’s Disease Rating Scale—part III; Disability of the Arm, Shoulder and Hand Questionnaire) before treatment, at the end of treatment and one month post treatment. After rehabilitation, a statistically significant improvement was observed in terms of global cognitive status, attention, global motor functioning and disability. The results suggest an impact of upper limb motor rehabilitation on cognition in Parkinson’s disease. Future studies on neuromotor interventions should investigate their effects on cognitive functioning to improve understanding of cognitive motor interaction in Parkinson’s disease.

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“…This imagery process can help people better prepare for the actual movement. Therefore, PMA is more obviously activated than MA during MI (Matsuo et al, 2021;Ma et al, 2022;Zou et al, 2022). The activity of the MA may be driven by the facilitating or inhibiting effect of the PMA.…”

Section: Pma Plays a Significant Role In MI And Mementioning

confidence: 99%

Variation in brain connectivity during motor imagery and motor execution in stroke patients based on electroencephalography

Guo,

Hu,

Wang

et al. 2024

Front. Neurosci.

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ObjectiveThe objective of this study was to analyze the changes in connectivity between motor imagery (MI) and motor execution (ME) in the premotor area (PMA) and primary motor cortex (MA) of the brain, aiming to explore suitable forms of treatment and potential therapeutic targets.MethodsTwenty-three inpatients with stroke were selected, and 21 right-handed healthy individuals were recruited. EEG signal during hand MI and ME (synergy and isolated movements) was recorded. Correlations between functional brain areas during MI and ME were compared.ResultsPMA and MA were significantly and positively correlated during hand MI in all participants. The power spectral density (PSD) values of PMA EEG signals were greater than those of MA during MI and ME in both groups. The functional connectivity correlation was higher in the stroke group than in healthy people during MI, especially during left-handed MI. During ME, functional connectivity correlation in the brain was more enhanced during synergy movements than during isolated movements. The regions with abnormal functional connectivity were in the 18th lead of the left PMA area.ConclusionLeft-handed MI may be crucial in MI therapy, and the 18th lead may serve as a target for non-invasive neuromodulation to promote further recovery of limb function in patients with stroke. This may provide support for the EEG theory of neuromodulation therapy for hemiplegic patients.

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Brain Function and Upper Limb Deficit in Stroke With Motor Execution and Imagery: A Cross-Sectional Functional Magnetic Resonance Imaging Study

Cited by 13 publications

References 51 publications

Morphological alterations of contralesional hemisphere relate to functional outcomes after stroke

Morphological alterations of contralesional hemisphere relate to functional outcomes after stroke

Effect of Upper Limb Motor Rehabilitation on Cognition in Parkinson’s Disease: An Observational Study

Variation in brain connectivity during motor imagery and motor execution in stroke patients based on electroencephalography

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