Brain fMRI Activation Associated with Self‐Paced Finger Tapping in Chronic Alcohol‐Dependent Patients

Parks, Mitchell H.; Morgan, Victoria L.; Pickens, David R.; Price, Ronald R.; Dietrich, Mary S.; Nickel, Mark K.; Martin, Peter

doi:10.1111/j.1530-0277.2003.tb04408.x

Cited by 37 publications

(17 citation statements)

References 77 publications

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“…The group differences observed are less likely due to cerebrovasculature abnormalities or problems in regions subserving motor functioning, as the adolescents with AUD showed normal BOLD response to the finger tapping task. This finding contrasts with that of Parks and colleagues (Parks et al, 2003) who found somewhat abnormal BOLD response during a simple motor task in alcohol dependent adults, suggesting that early in the course of AUD, the neural substrates of motor functions may remain intact, while those of more difficult or complex functions such as working memory could be affected.…”

Section: Discussioncontrasting

confidence: 96%

Blood Oxygen Level Dependent Response and Spatial Working Memory in Adolescents With Alcohol Use Disorders

Tapert

Schweinsburg

Barlett

et al. 2004

Alcoholism Clin & Exp Res

199

193

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Background: Previous studies have suggested neural disruption and reorganization in young and older adults with alcohol use disorders (AUD). However, it remains unclear at what age and when in the progression of AUD changes in brain functioning might occur. Methods: Alcohol use disordered (n=15) and nonabusing (n=19) males and females ages 15-17 were recruited from local high schools. Functional magnetic resonance imaging (fMRI) data were collected after a minimum of 5 days' abstinence as participants performed spatial working memory and simple motor tasks. Results: Adolescents with AUD showed greater brain response to the spatial working memory task in bilateral parietal cortices, and diminished response in other regions including the left precentral gyrus and bilateral cerebellar areas (clusters ≥ 943 μl, p < .05), although groups did not differ on behavioral measures of task performance. No brain response differences were observed during a simple finger tapping task. The degree of abnormality was greater for teens who reported experiencing more withdrawal or hangover symptoms, and who consumed more alcohol. Conclusions: Adolescents with AUD show abnormalities in brain response to a spatial working memory task, despite adequate performance, suggesting that subtle neuronal reorganization may occur early in the course of AUD.

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Section: Discussioncontrasting

confidence: 96%

Blood Oxygen Level Dependent Response and Spatial Working Memory in Adolescents With Alcohol Use Disorders

Tapert

Schweinsburg

Barlett

et al. 2004

Alcoholism Clin & Exp Res

199

193

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“…Moreover, there were no group differences on RT to first button press for any trial type. Although there has been evidence for motor deficits in ADPs (Parks et al, 2003), we only found a trend toward increased RT for sustained motor activity in the ADPs. Taken together, the behavioral RT results indicate that there was not a motor deficit in the ADPs.…”

Section: Discussioncontrasting

confidence: 92%

Altered Striatal Response During Effort-Based Valuation and Motivation in Alcohol-Dependent Individuals

Grodin

Steckler

Momenan

2016

Alcohol and Alcoholism

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Aims: To use functional magnetic resonance imaging (fMRI) to investigate the neural circuitry behind effort-related valuation and motivation in a population of alcohol-dependent participants and healthy controls. Methods: Seventeen alcohol-dependent participants and a comparison group of 17 healthy control participants completed an effort-based motivation paradigm during an fMRI scan, in which they were required to exert effort at varying levels in order to earn a monetary reward. Results: We found that alcohol-dependent participants were less motivated during trials requiring high levels of effort. The whole-brain fMRI analysis revealed that alcohol-dependent participants displayed an increased blood-oxygen-level dependent (BOLD) signal during low and unknown effort cues in the dorsal and ventral striatum compared with healthy controls. Conclusion: These findings provide the first evidence that alcohol-dependent participants and healthy controls differ in their effort-based valuation and motivation processing. Alcohol-dependent participants displayed a hyperactive mesolimbic reward circuitry recruited by non-drug rewards, potentially reflecting a sensitization to reward in this patient population.

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“…Several fMRI studies reveal that alcoholics activate either a different neural network (Pfefferbaum et al, 2001; Tapert et al, 2001; Tapert et al, 2004) or activate appropriate regions but more widely (Desmond et al, 2003; Parks et al, 2003) to perform behaviorally (e.g., in terms of accuracy or reaction time) on par with controls. For example, self-paced finger-tapping activated frontocerebellar networks in controls (e.g., anterior cingulate, anterior lobe and vermis of the cerebellum) but only the parietal precuneus in alcoholics (Parks et al, 2010).…”

Section: Brain Structures and Systems Affected In Individuals With Almentioning

confidence: 99%

Contributions of Studies on Alcohol Use Disorders to Understanding Cerebellar Function

et al. 2010

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Neuropathological, neuropsychological, and neuroimaging studies of human alcoholism provide evidence for degradation of frontal, pontine, thalamic, and cerebellar brain sites and disturbed associated functions. Current studies using neuroimaging combined with examination of executive functions, traditionally considered the sole purview of the frontal lobes, have identified a role for the cerebellum serving as a compensatory processing adjunct to enable normal performance on challenging tasks tapping executive functions. This overview proposes that disruption of an executive frontocerebellar network is a major contributor to characteristic behaviors of alcoholism that, on the one hand, enable alcohol use disorders, and on the other hand, lead to compensation for so-called frontally-based dysfunctions in alcoholism.

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Brain fMRI Activation Associated with Self‐Paced Finger Tapping in Chronic Alcohol‐Dependent Patients

Cited by 37 publications

References 77 publications

Blood Oxygen Level Dependent Response and Spatial Working Memory in Adolescents With Alcohol Use Disorders

Blood Oxygen Level Dependent Response and Spatial Working Memory in Adolescents With Alcohol Use Disorders

Altered Striatal Response During Effort-Based Valuation and Motivation in Alcohol-Dependent Individuals

Contributions of Studies on Alcohol Use Disorders to Understanding Cerebellar Function

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