Brain-evoked potentials as a tool for diagnosing neuropathic pain

Pazzaglia, Costanza; Valeriani, Massimiliano

doi:10.1586/ern.09.16

Cited by 15 publications

(9 citation statements)

References 122 publications

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“…Furthermore, topographical analysis showed that the chronic pain group exhibited predominantly frontal cortical activity, compared to central activation in the control group. These findings are in accordance with previous results showing a response latency of about 250 ms [26], an increased size and reduction in population spike frequency [27], and restriction of some ERP components to frontal-central regions in patients with fibromyalgia syndrome [28]. Our findings indicate that the PARAFAC method is an effective technique for extracting the characteristics of multiple EEG recordings in the time-frequency-channel domain.…”

Section: Discussionsupporting

confidence: 93%

Characteristics of Evoked Potential Multiple EEG Recordings in Patients with Chronic Pain by Means of Parallel Factor Analysis

Wang

et al. 2012

Computational and Mathematical Methods in Medicine

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This paper presents an alternative method, called as parallel factor analysis (PARAFAC) with a continuous wavelet transform, to analyze of brain activity in patients with chronic pain in the time-frequency-channel domain and quantifies differences between chronic pain patients and controls in these domains. The event related multiple EEG recordings of the chronic pain patients and non-pain controls with somatosensory stimuli (pain, random pain, touch, random touch) are analyzed. Multiple linear regression (MLR) is applied to describe the effects of aging on the frequency response differences between patients and controls. The results show that the somatosensory cortical responses occurred around 250 ms in both groups. In the frequency domain, the neural response frequency in the pain group (around 4 Hz) was less than that in the control group (around 5.5 Hz) under the somatosensory stimuli. In the channel domain, cortical activation was predominant in the frontal region for the chronic pain group and in the central region for controls. The indices of active ratios were statistical significant between the two groups in the frontal and central regions. These findings demonstrate that the PARAFAC is an interesting method to understanding the pathophysiological characteristics of chronic pain.

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Section: Discussionsupporting

confidence: 93%

Characteristics of Evoked Potential Multiple EEG Recordings in Patients with Chronic Pain by Means of Parallel Factor Analysis

Wang

et al. 2012

Computational and Mathematical Methods in Medicine

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“…The feature extracted by PARAFAC was around 250 ms in the prefrontal and parietal regions. It is noticeable that the feature matches with the corresponding ERP results (Figure 2A, d and Figure 2B, d) and with previous LEP findings that the N2/P2 complex components peaks in the frontal region at approximately 250 ms after stimulus onset (24). These results provided further evidence as suggested by Wang (16) that the PARAFAC is an interesting method to detect the principal character of LEP.…”

Section: Discussionsupporting

confidence: 91%

The Frontal Area with Higher Frequency Response Is the Principal Feature of Laser-Evoked Potentials in Rats with Chronic Inflammatory Pain: A Parallel Factor Analysis Study

Wang

Wan

et al. 2017

Front. Neurol.

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Chronic pain is a pathological developing course of pain. In clinic, an objective indicator is needed for diagnosing and better controlling chronic pain. The abnormal neural responses in chronic pain are reflected by multiple event-related potentials (ERPs) in time, frequency, and location domain, respectively. However, multiple changes in ERPs are not applicable in clinic. So, the principal feature covered the most informative changes extracted from these three domains of ERP during the development of chronic pain is needed. In the present study, a parallel factor analysis method was employed to extract time–frequency–channel features of laser-evoked potential (LEP) simultaneously from rats with chronic inflammatory pain. Results showed that the main feature of LEP in channel domain locates in the frontal brain region in rats with chronic inflammatory pain while in the parietal brain region in control rats. In the frequency domain, the main frequency of LEP was significantly higher in chronic inflammatory pain rats than that in control rats. These findings indicate that the frontal region with higher frequency response to nociceptive information is the principal feature in the chronic pain state. Our study provided not only a principal feature of LEP but also a promising strategy for chronic pain, which is potential for clinic application.

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“…The findings that N2-wave latency correlated with sensory sensitivity and higher socio-emotional problems in ASD suggest its potential role as a salient physiological indicator for a sensory disturbance in ASD. In previous laser-evoked potential studies, the N2-wave component originated mainly from the ACC 49 , and may also reflect neuronal activity in the primary or secondary sensory cortex as well as the dorsal posterior insula 50 51 . The activation of ACC may play an integrative role, directing attention to the stimuli and preparing a motor reaction 31 , while sensory cortex activation was specifically involved in the recognition of the noxious nature of stimuli 52 .…”

Section: Discussionmentioning

confidence: 90%

Attenuated contact heat-evoked potentials associated with sensory and social-emotional symptoms in individuals with autism spectrum disorder

Chien

Chu

et al. 2017

Sci Rep

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Sensory disturbance is associated with socio-emotional problems in individuals with autism spectrum disorder (ASD). Most studies assess sensory symptoms by self-reports, which are largely limited by the language ability and self-awareness of the individuals. This study aims to investigate sensory disturbance by contact heat-evoked potentials (CHEP) in ASD individuals, and to examine the clinical correlates of CHEP parameters. We compared the CHEP parameters and reported pain between 31 ASD individuals (aged 20.5 ± 5.2 years) and and 22 typically-developing controls (TD, aged 21.4 ± 2.6), and correlated the CHEP parameters with self-reported sensory symptoms and attention/socio-emotional symptoms. We found that ASD individuals showed smaller P2-wave amplitudes than TD, even though they reported a similar level of pain. In TD individuals, a smaller P2-wave amplitude was related to higher scores on ‘low registration,’ ‘attention to detail,’ and ‘attention switching difficulties.’ In ASD individuals, longer N2-wave latency was related to higher scores on ‘sensory sensitivity’ and socio-emotional problems; while higher reported pain was associated with higher scores on ‘low registration,’ overall autistic severity, and longer N2-wave latency. Our findings of attenuated CHEP response in ASD, which was associated with sensory symptoms and socio-emotional problems, suggest a potential role for CHEP in studying sensory disturbances in ASD.

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Brain-evoked potentials as a tool for diagnosing neuropathic pain

Cited by 15 publications

References 122 publications

Characteristics of Evoked Potential Multiple EEG Recordings in Patients with Chronic Pain by Means of Parallel Factor Analysis

Characteristics of Evoked Potential Multiple EEG Recordings in Patients with Chronic Pain by Means of Parallel Factor Analysis

The Frontal Area with Higher Frequency Response Is the Principal Feature of Laser-Evoked Potentials in Rats with Chronic Inflammatory Pain: A Parallel Factor Analysis Study

Attenuated contact heat-evoked potentials associated with sensory and social-emotional symptoms in individuals with autism spectrum disorder

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