Brain endothelial cells increase the proliferation of Plasmodium falciparum through production of soluble factors

Khaw, Loke Tim; Ball, Helen J.; Mitchell, Andrew J.; Grau, Georges E.; Stocker, Roland; Golenser, Jacob; Hunt, Nicholas H.

doi:10.1016/j.exppara.2014.07.002

Cited by 2 publications

(2 citation statements)

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“…Malaria is the most prevalent tropical disease, which annually infects 300-500 million individuals worldwide (CDC.org). It is estimated that 2-3 million people are at risk every year, most of whom are children who die from the infection without the proper treatment along with the development of other [74] Produces low molecular weight growth factors, which enhance the parasite proliferation [75] Leishmania spp.…”

Section: Malariamentioning

confidence: 99%

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Risk of aortic dissection in patients with ascending aorta aneurysm: a new biological, morphological, and biomechanical network behind the aortic diameter

Jha¹,

Holcomb²,

McDaniel³

et al. 2022

Vessel Plus

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The vascular endothelium is a vital component in maintaining the structure and function of blood vessels. The endothelial cells (ECs) mediate vital regulatory functions such as the proliferation of cells, permeability of various tissue membranes, and exchange of gases, thrombolysis, blood flow, and homeostasis. The vascular endothelium also regulates inflammation and immune cell trafficking, and ECs serve as a replicative niche for many bacterial, viral, and protozoan infectious diseases. Endothelial dysfunction can lead to vasodilation and pro-inflammation, which are the hallmarks of many severe diseases. Exosomes are nanoscale membrane-bound vesicles that emerge from cells and serve as important extracellular components, which facilitate communication between cells and maintain homeostasis during normal and pathophysiological states. Exosomes are also involved in gene transfer, inflammation and antigen presentation, and mediation of the immune response during pathogenic states. Protozoa are a diverse group of unicellular organisms that cause many infectious diseases in humans. In this regard, it is becoming increasingly evident that many protozoan parasites (such as Plasmodium , Trypanosoma, Leishmania , and Toxoplasma) utilize exosomes for the transfer of their virulence factors and effector molecules into the host cells, which manipulate the host gene expression, immune responses, and other biological activities to establish and modulate infection. In this review, we discuss the role of the vascular endothelium and exosomes in and

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Section: Malariamentioning

confidence: 99%

“…In addition, a recent study suggests that brain ECs produce low molecular weight growth factors, which stimulate the growth of P. falciparum in vitro. These growth factors potentially enhance parasite proliferation in erythrocytes in the brain microvasculature [75] .…”

Section: Role Of the Ve In Malariamentioning

confidence: 99%