Brain effects of the lectin from<i>Canavalia ensiformis</i>in adult rats previously suckled in favorable and unfavorable conditions: A spreading depression and microglia immunolabeling study

Soares, Geórgia de Sousa Ferreira; Lima, Cássia Borges; Cavalcanti, Liliane Cabral; Villacampa, Nàdia; Castellano, Bernardo; Guedes, Rubem Carlos Araújo

doi:10.1179/1476830514y.0000000128

Cited by 7 publications

(4 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several studies have demonstrated the ability of substances that facilitate the spread of CSD, such as monosodium glutamate [ 40 ] and tianeptine [ 41 ], and other compounds that prevent the spread of this electrophysiological phenomenon, such as lectins [ 42 ]. In particular, ethanol has different effects depending on the concentration or exposure frequency, that can facilitate the CSD, and this justifies the higher CSD velocity in cachaça -group rats treated.…”

Section: Resultsmentioning

confidence: 99%

Chlorella vulgaris functional alcoholic beverage: Effect on propagation of cortical spreading depression and functional properties

et al. 2021

View full text Add to dashboard Cite

Recent advances in microalgae biotechnology have proven that these microorganisms contain a number of bioactive molecules, that can be used as food additives that help prevent disease. The green microalga Chlorella vulgaris presents several biomolecules, such as lutein and astaxanthin, with antioxidant capacity, which can play a protective role in tissues. In this study, we produced and analyzed a C. vulgaris functional alcoholic beverage (produced using a traditional Brazilian alcoholic beverage, cachaça, and C. vulgaris biomass). Assays were conducted in vitro by radical scavenging tests, and in vivo, by modeling cortical spreading depression in rat brains. Scavenging radical assays showed that consumption of the C. vulgaris alcoholic beverage had a DPPH inhibition of 77.2%. This functional alcoholic beverage at a concentration of 12.5 g L-1 significantly improved cortical spreading depression velocity in the rat brains (2.89 mm min-1), when compared with cachaça alone (3.68 mm min-1) and control (distilled water; 3.25 mm min-1). Moreover, animals that consumed the functional beverage gained less weight than those that consumed just alcohol and the control groups. These findings suggest that the C. vulgaris functional alcoholic beverage plays a protective physiologic role in protecting brain cells from the effects of drinking ethanol.

show abstract

Section: Resultsmentioning

confidence: 99%

Chlorella vulgaris functional alcoholic beverage: Effect on propagation of cortical spreading depression and functional properties

et al. 2021

View full text Add to dashboard Cite

show abstract

“…This lectin caused a potentiation of the fluoxetine action, a selective serotonin reuptake inhibitor, leading to a decrease of the mouse immobility time during forced swimming tests [ 163 ]. Furthermore, rats treated with the Canavalia ensiformis concanavalin A dose-dependently demonstrated a velocity decrease of the cortical spreading depression propagation and an increase of the amplitude and the duration of the cortical spreading depression potential [ 164 ].…”

Section: Biotechnological Potentialmentioning

confidence: 99%

Porifera Lectins: Diversity, Physiological Roles and Biotechnological Potential

et al. 2015

View full text Add to dashboard Cite

An overview on the diversity of 39 lectins from the phylum Porifera is presented, including 38 lectins, which were identified from the class of demosponges, and one lectin from the class of hexactinellida. Their purification from crude extracts was mainly performed by using affinity chromatography and gel filtration techniques. Other protocols were also developed in order to collect and study sponge lectins, including screening of sponge genomes and expression in heterologous bacterial systems. The characterization of the lectins was performed by Edman degradation or mass spectrometry. Regarding their physiological roles, sponge lectins showed to be involved in morphogenesis and cell interaction, biomineralization and spiculogenesis, as well as host defense mechanisms and potentially in the association between the sponge and its microorganisms. In addition, these lectins exhibited a broad range of bioactivities, including modulation of inflammatory response, antimicrobial and cytotoxic activities, as well as anticancer and neuromodulatory activity. In view of their potential pharmacological applications, sponge lectins constitute promising molecules of biotechnological interest.

show abstract

“…Concanavalin-A (ConA)-induced acute liver injury is a well-established experimental model of immune cells resembling the autoimmune and viral hepatitis in humans [10]. ConA is a plant lectin obtained from Canavalia brasiliensis that induces hepatitis in experimental models by activating T-cells and the release of many inflammatory cytokines (IFN-γ, TNF-α and IL-6) by stimulating Kuppfer cells [11,12]. Overproduction of these inflammatory mediators causes asymptomatic increase in liver transaminase enzyme levels as well as serum proteins, the principal indicators of liver injury [13].…”

Section: Introductionmentioning

confidence: 99%

Glycyrrhizin, Curcumin and Cinnamon Prevent From Concanavalin-A and Acetaminophen-Induced Liver Injury and Oxidative Stress in Mouse Model

Hussain

Rashid

Mushtaq

et al. 2022

Lifsc

View full text Add to dashboard Cite

Daily exposure to a number of xenobiotics is the major contributing factor to liver injury. The present study investigated the mechanism of hepatoprotection by glycyrrhizin, curcumin and cinnamon in two distinct models of hepatotoxicity i.e., by using Concanavalin-A (ConA) and Acetaminophen (APAP). For this evaluation, balb/c mice were pretreated with glycyrrhizin (200 mg/kg i.g.), curcumin (100 mg/kg i.g.) and cinnamon (200 mg/kg i.g.) extracts for 14 days followed by administration of ConA (15 mg/kg i.v.) and APAP (200 mg/kg i.p.) for 8 hours. At the end of the experiment, mice were dissected and blood and liver samples were collected for biochemical and histopathological analysis. Statistical analysis by using one-way ANOVA followed by DMR test was performed for the significance of results. The results showed that pre-treatment of glycyrrhizin, curcumin and cinnamon ameliorated the damaging effects of ConA and APAP on the liver as indicated by the serum transaminase enzymes and total protein levels. In addition, ConA and APAP exerted severe damage on liver tissues as confirmed from the histopathological analysis. However, glycyrrhizin, curcumin and cinnamon prevented liver injury, possibly through antioxidant mechanism. In conclusion, glycyrrhizin, curcumin and cinnamon possessed antioxidant properties with therapeutic potential in liver injury related to oxidative stress.

show abstract

Brain effects of the lectin fromCanavalia ensiformisin adult rats previously suckled in favorable and unfavorable conditions: A spreading depression and microglia immunolabeling study

Cited by 7 publications

References 53 publications

Chlorella vulgaris functional alcoholic beverage: Effect on propagation of cortical spreading depression and functional properties

Chlorella vulgaris functional alcoholic beverage: Effect on propagation of cortical spreading depression and functional properties

Porifera Lectins: Diversity, Physiological Roles and Biotechnological Potential

Glycyrrhizin, Curcumin and Cinnamon Prevent From Concanavalin-A and Acetaminophen-Induced Liver Injury and Oxidative Stress in Mouse Model

Contact Info

Product

Resources

About