Brain Dynamics of Mild Cognitive Impairment (MCI) from EEG Features

Fauzan, Norsiah; Amran, Nur Hurunain

doi:10.1016/j.sbspro.2014.12.633

Cited by 9 publications

(14 citation statements)

References 7 publications

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“…Indeed, during resting state condition, the MCI group showed increased alpha, beta, delta, and theta power compared to the control group. These results confirm previous studies demonstrating higher EEG power in the alpha, beta, and theta bands in MCI patients [ 27 ], which correlated negatively with global cognitive performance, i.e., MMSE scores [ 26 ]. This means that when EEG power increases, the MMSE scores decrease which could be a sign of cognitive decline.…”

Section: Discussionsupporting

confidence: 91%

“…Another study reported increased alpha and beta band power in addition to increased theta power and a negative correlation with Mini-Mental State Examination (MMSE) scores [ 26 ]. Similar results in regards to beta and theta bands have been reported by Fauzan and Amral [ 27 ]. Studies have also shown an increase in theta power in MCI patients compared to healthy controls [ 27 ], which correlated with hippocampal volume loss [ 28 ].…”

Section: Introductionsupporting

confidence: 91%

“…Similar results in regards to beta and theta bands have been reported by Fauzan and Amral [ 27 ]. Studies have also shown an increase in theta power in MCI patients compared to healthy controls [ 27 ], which correlated with hippocampal volume loss [ 28 ]. Alpha, theta and delta power and coherence have been found to be higher in amplitude in MCI to AD converters compared to stable subjects [ 29 ].…”

Section: Introductionsupporting

confidence: 91%

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A Comparison of Traditional and Serious Game-Based Digital Markers of Cognition in Older Adults with Mild Cognitive Impairment and Healthy Controls

Iliadou

Paliokas

Zygouris

et al. 2021

JAD

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Background: Electroencephalography (EEG) has been used to assess brain activity while users are playing an immersive serious game. Objective: To assess differences in brain activation as measured with a non-intrusive wearable EEG device, differences in game performance and correlations between EEG power, game performance and global cognition, between cognitively impaired and non-impaired older adults, during the administration of a novel self-administered serious game-based test, the Virtual Supermarket Test (VST). Methods: 43 older adults with subjective cognitive decline (SCD) and 33 older adults with mild cognitive impairment (MCI) were recruited from day centers for cognitive disorders. Global cognition was assessed with the Montreal Cognitive Assessment (MoCA). Brain activity was measured with a non-intrusive wearable EEG device in a resting state condition and while they were administered the VST. Results: During resting state condition, the MCI group showed increased alpha, beta, delta, and theta band power compared to the SCD group. During the administration of the VST, the MCI group showed increased beta and theta band power compared to the SCD group. Regarding game performance, alpha, beta, delta, and theta rhythms correlated with average duration, while delta rhythm was positively correlated with mean errors. MoCA correlated with alpha, beta, delta, and theta rhythms and with average game duration and mean game errors indicating that elevated EEG rhythms in MCI may be associated with an overall cognitive decline. Conclusion: VST performance can be used as a digital biomarker. Cheap commercially available wearable EEG devices can be used for obtaining brain activity biomarkers.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionsupporting

confidence: 91%

Section: Introductionsupporting

confidence: 91%

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A Comparison of Traditional and Serious Game-Based Digital Markers of Cognition in Older Adults with Mild Cognitive Impairment and Healthy Controls

Iliadou

Paliokas

Zygouris

et al. 2021

JAD

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“…And their research showed that the changes of the d band of EEG signals at the prefrontal area and the central regions for the normal are associated with cognitive level. 31 Researches show that the change of human alertness is consistent with the change of HRV. [32][33][34] Previous studies have shown that the HRV was associated with human neurocognitive activities.…”

Section: Introductionmentioning

confidence: 81%

Study of driving skill level discrimination based on human physiological signal characteristics

Wang

et al. 2018

RSC Adv.

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“…In AD, theta and delta rhythms are abnormally more dominant in temporal regions of the brain than in other cerebral regions and posterior alpha rhythms significantly decrease [9–13]. Other promising studies in pathophysiology revealed that patients with MCI showed dominant theta activity in the parietal and temporal areas [14–16]. Moretti et al showed in numerous studies that the abnormal increase in the power ratio alpha3/alpha2 in temporo-parietal brain regions is correlated with hippocampal atrophy in MCI and AD patients [17–19].…”

Section: Introductionmentioning

confidence: 99%

Comparison of effects between SMR/delta-ratio and beta1/theta-ratio neurofeedback training for older adults with Mild Cognitive Impairment: a protocol for a randomized controlled trial

Marlats

Djabelkhir-Jemmi

Azabou

et al. 2019

Trials

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BackgroundOlder adults with Mild Cognitive Impairment (MCI) are at high risk of progressing to Alzheimer’s disease (AD). Slowing down the effect of dementia by enhancing brain plasticity represents one of the most prominent challenges. Neurofeedback (NF) has shown promising results in improving working memory but has never been evaluated in people with MCI. We aim to examine whether NF training can decrease cognitive disorders, targeting memory, attention functions and brain electrical activity in elderly patients with MCI.MethodsIn this single-blind, randomized controlled trial (RCT) protocol, we will investigate the effects of two NF training protocols on cognitive performances and on brain electrical activity. Sixty MCI patients will be assigned either to an intervention program or to psycho-pedagogical care as a control condition. Participants in the intervention group will attend 30 sessions of sensorimotor/delta-ratio NF training or beta1/theta-ratio NF training. Neuropsychological assessment, questionnaires and electroencephalography (EEG) assessment parameters will be used as dependent variables in three periods: at baseline (T0), immediately after the last NF training session at 4 months (T1) and at 3-month follow-up (T2). The primary outcome will be the change in attention measured with the Trail Making Test B. Secondary outcome will be the changes in cognitive performance and in EEG activities.DiscussionIf the results of our study show improvement in cognitive performances of older adults with MCI, this non-invasive, low-cost technique may deserve better consideration as a therapeutic intervention to delay cognitive decline and dementia. Consequently, research in NF will need to review and develop the rigor of its application in gerontology.Trial registrationClinicalTrials.gov, ID: NCT03526692. Registered on 16 May 2018.Electronic supplementary materialThe online version of this article (10.1186/s13063-018-3170-x) contains supplementary material, which is available to authorized users.

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Brain Dynamics of Mild Cognitive Impairment (MCI) from EEG Features

Cited by 9 publications

References 7 publications

A Comparison of Traditional and Serious Game-Based Digital Markers of Cognition in Older Adults with Mild Cognitive Impairment and Healthy Controls

A Comparison of Traditional and Serious Game-Based Digital Markers of Cognition in Older Adults with Mild Cognitive Impairment and Healthy Controls

Study of driving skill level discrimination based on human physiological signal characteristics

Comparison of effects between SMR/delta-ratio and beta1/theta-ratio neurofeedback training for older adults with Mild Cognitive Impairment: a protocol for a randomized controlled trial

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