Brain Dynamics in Response to Intermittent Photic Stimulation in Epilepsy

Abstract

Purpose: Routine electroencephalogram (EEG) examinations uses intermittent photic stimulation (IPS) for investigation of the visual cortex EEG responses during resting time. This study aimed to discover brain dynamics effects of IPS in 28 generalized epilepsy patients and 28 healthy subjects. Methodology: Signal processing techniques were used in feature extraction by Fast Fourier transform (FFT), feature dimension reduction by t-test (significant, p<0.05) and classification by nearest neighbor (k-NN) and support vector machine (SVM). Results: The epilepsy group had higher level of amplitude in Theta waves compared to the healthy group. The Alpha waves in the resting time and for all IPS frequencies were observed with lower level of amplitude in healthy subjects compared to the epilepsy group. The k-NN (85.7% accuracy) classifier had the best discrimination of epilepsy from healthy group for resting time versus during IPS at 18 Hz IPS. However, using SVM (75.0% accuracy), IPS at 25 Hz yielded the best discrimination between resting time versus IPS in epilepsy where the healthy group responded similarly in all IPS frequencies. Conclusions: This study shows that IPS at 18 Hz and 25 Hz are suitable IPS frequencies for k-NN and SVM, respectively, to discriminate non-photosensitive generalized epilepsy from normal subjects during interictal.

A Classification Model of EEG Signals Based on RNN-LSTM for Diagnosing Focal and Generalized Epilepsy

“…The study reached a 99% accuracy in distinguishing healthy controls from subjects with epilepsy, with or without seizures. An interictal seizure-free period has been analyzed by [ 16 ] using triggering signals of intermittent photic stimulation (IPS) reporting frequency domain features; the theta band is the most fitting feature in diagnosing generalized epilepsy in the visual cortex. This classification has been done with a support vector machine (SVM) in 18 Hz IPS, reaching the best discrimination between groups.…”