Brain dopamine depletion by lesions in the substantia nigra attenuates the development of hypertension in the spontaneously hypertensive rat

Buuse, Maarten van den; Versteeg, Dirk H.G.; Jong, W. De

doi:10.1016/0006-8993(86)91043-7

Cited by 41 publications

(1 citation statement)

References 26 publications

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“…Consistently, depletion of DA by 6-hydroxydopamine lesion of the substantia nigra of SHR decreases the magnitude of adult hypertension (van den Buuse et al, 1985(van den Buuse et al, , 1986Linthorst et al, 1994; de Jong et al, 1995). Interestingly, intensive postnatal handling can reduce the difference between SHR and WKY in terms of the basal levels of DA and locomotor activity (Ferguson & Cada, 2003;Ferguson et al, 2003), possibly due to a reshaping of the neural networks (Sadile, 1999).…”

Section: Synthesis Clearance Concentration and Effects Of Da In Anmentioning

confidence: 90%

Dysfunctions in Dopamine Systems and ADHD: Evidence From Animals and Modeling

2004

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Animal models are useful for characterizing neural substrates of neuropsychiatric disorders. Several models have been proposed for the study of Attention Deficit Hyperactivity Disorder (ADHD). The models can be divided into various groups: (i) genetically derived hyperactivity/ inattention, (ii) animal models showing symptoms after pharmacological intervention, and (iii) those based on spontaneous variations in a random population. Spontaneously hypertensive (SHR) and Naples High Excitability (NHE) rats show behavioral traits featuring the main aspects of ADHD in humans but show different changes in dopamine (DA) systems. In fact, the enzyme tyrosine hydroxylase is hyperexpressed in NHE rats and hypoexpressed in SHR. The DA transporter is hyperexpressed in both lines, although in the SHR, DAT activity is low (reduced DA uptake). The DA levels in the striatum and prefrontal cortex are increased in the juvenile SHR, but are decreased in handled young and non-handled older animals. The mRNA of the D1 DA receptor is upregulated in the prefrontal cortex of SHR and downregulated in NHE. The D2 DA receptors are likely to be hypofunctioning in SHR, although the experimental evidence is not univocal, whereas their mRNA is hyperexpressed in NHE. Thus, in SHR both the mesocortical and mesolimbic DA pathways appear to be involved, whereas in NHE only the mesocortical system. To understand the effects of methylphenidate, the elective ADHD drug treatment in humans, in a dysfunctioning DA system, we realized a simple mathematical model of DA regulation based on experimental data from electrophysiological, cyclic voltammetry, and microdialysis studies. This model allows the estimation of a higher firing frequency of DA neurons in SHR rats and suggests that methylphenidate increases attentive processes by regulating the firing rate of DA neurons.

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Section: Synthesis Clearance Concentration and Effects Of Da In Anmentioning

confidence: 90%

Dysfunctions in Dopamine Systems and ADHD: Evidence From Animals and Modeling

2004

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Pressor Effects of Electrical Stimulation of the Rat Ventral Tegmental A10 Dopamine System

Buuse

Lambrechts

Jong

1988

Pharmacology and Functional Regulation of Dopaminergic Neurons

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Cause of death among patients with Parkinson's disease: a rare mortality due to cerebral haemorrhage

et al. 1990

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Causes of death, with special reference to cerebral haemorrhage, among 240 patients with pathologically verified Parkinson's disease were investigated using the Annuals of the Pathological Autopsy Cases in Japan from 1981 to 1985. The leading causes of death were pneumonia and bronchitis (44.1%), malignant neoplasms (11.6%), heart diseases (4.1%), cerebral infarction (3.7%) and septicaemia (3.3%). Cerebral haemorrhage was the 11th most frequent cause of death, accounting for only 0.8% of deaths among the patients, whereas it was the 5th most common cause of death among the Japanese general population in 1985. The low incidence of cerebral haemorrhage as a cause of death in patients with Parkinson's disease may reflect the hypotensive effect of levodopa and a hypotensive mechanism due to reduced noradrenaline levels in the parkinsonian brain.

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Brain dopamine depletion by lesions in the substantia nigra attenuates the development of hypertension in the spontaneously hypertensive rat

Cited by 41 publications

References 26 publications

Dysfunctions in Dopamine Systems and ADHD: Evidence From Animals and Modeling

Dysfunctions in Dopamine Systems and ADHD: Evidence From Animals and Modeling

Pressor Effects of Electrical Stimulation of the Rat Ventral Tegmental A10 Dopamine System

Cause of death among patients with Parkinson's disease: a rare mortality due to cerebral haemorrhage

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