Brain-Derived Neurotrophic Factor Polymorphism Val66Met Protects Against Cancer-Related Fatigue

Feng, Linyin; Juneau, Paul; Regan, Jeniece; Liwang, Josephine; Alshawi, Sarah; Wang, Angela Yee-Moon; Saligan, Leorey N.

doi:10.2139/ssrn.3562466

Cited by 2 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fatigue phenotypes associated with different types of cancer may arise from various pathogenic processes 1 . However, emerging evidence suggests that the common theme among these different etiologies may be related to intrinsic genetic vulnerability combined with inflammatory triggers related to cancer or cancer treatment 2,7‐10 …”

Section: Introductionmentioning

confidence: 99%

“…1 However, emerging evidence suggests that the common theme among these different etiologies may be related to intrinsic genetic vulnerability combined with inflammatory triggers related to cancer or cancer treatment. 2,[7][8][9][10] Metabolomics, or metabolome profiling, is the newest addition to the -omics methodology and refers to the global identification and quantification of metabolites. 11 By definition, metabolites are small molecule metabolic products that result from chemical transformation during metabolism and, therefore, provide a real-time functional snapshot of the biochemical activity and cellular state.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Plasma metabolomic profile associated with fatigue in cancer patients

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Plasma metabolomic profile associated with fatigue in cancer patients

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…Here, we found that BDNF Met/Met mice had greater AT efficacy to promote both visual discrimination and cognitive flexibility, regardless of sex. This along with other potential advantages of the BDNF Met/Met SNP such as slower rates of cognitive decline (Barha et al, 2019b, van der Kolk et al, 2015), and protection against cancer-related fatigue (Feng et al, 2020), may in part explain why this SNP is conserved in many populations.…”

Section: Discussionmentioning

confidence: 99%

Sex and BDNF Val66Met Polymorphism matter for exercise-induced increase in neurogenesis and cognition in middle-aged mice

Islas

Splinter

Ibrahim

et al. 2022

Preprint

View full text Add to dashboard Cite

Females show greater benefits of exercise on cognition in both humans and rodents, which may be related to brain-derived neurotropic factor (BDNF). A single nucleotide polymorphism (SNP), the Val66Met polymorphism, within the human BDNF gene, causes impaired activity-dependent secretion of neuronal BDNF and impairments to some forms of memory. We evaluated whether sex and BDNF genotype (Val66Met polymorphism (Met/Met) versus Wild Type (Val/Val)) influenced the ability of voluntary running to increase neurogenesis and cognition in mice. C57BL/6J (13 months) mice were randomly assigned to either a control or an aerobic training (AT) group (running disk access). Mice were trained on the visual discrimination and reversal paradigm in a touch screen-based technology to evaluate cognitive flexibility. BDNF Val/Val mice outperformed BDNF Met/Met mice on both cognitive tasks. Female BDNF Val/Val mice showed greater cognitive flexibility compared to male mice regardless of AT. Despite running less than BDNF Val/Val mice, AT improved both cognitive tasks in BDNF Met/Met mice. AT increased neurogenesis in the ventral hippocampus of BDNF Val/Val mice of both sexes and increased the proportion of mature type 3 doublecortin-expressing cells in the dorsal hippocampus of female mice only. Our results indicate AT results in improved cognitive performance in BDNF Met/Met mice and increased hippocampal neurogenesis in BDNF Val/Val mice in middle age. Furthermore, middle-aged female mice may benefit more from AT than males in terms of neuroplasticity, an effect that was influenced by the BDNF Val66Met polymorphism.

show abstract

Brain-Derived Neurotrophic Factor Polymorphism Val66Met Protects Against Cancer-Related Fatigue

Cited by 2 publications

References 0 publications

Plasma metabolomic profile associated with fatigue in cancer patients

Plasma metabolomic profile associated with fatigue in cancer patients

Sex and BDNF Val66Met Polymorphism matter for exercise-induced increase in neurogenesis and cognition in middle-aged mice

Contact Info

Product

Resources

About