Brain-derived neurotrophic factor plasma levels are increased in older women after an acute episode of low back pain

Diz, Juliano Bergamaschine Mata; Moreira, Bruno de Souza; Felício, Diogo Carvalho; Teixeira, Luiza Faria; Jesus-Moraleida, Fabianna Resende de; Queiroz, Bárbara Zille de; Pereira, Daniele Sirineu; Pereira, Leani Souza Máximo

doi:10.1016/j.archger.2017.03.005

Cited by 13 publications

(13 citation statements)

References 60 publications

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“…In the meantime, the reduction in BDNF serum level in our CG comes in opposition with the results of a study in which aquatic physical therapy twice per week for 5 weeks increased the level of BDNF [3]. In another study, [4] the use of analgesic or antidepressant drugs induced a significant reduction of serum BDNF in old women after an acute episode of LBP. Extrapolating, we can consider that balneal therapy, without sapropelic mud, may have the same effect over serum BDNF levels.…”

Section: Resultscontrasting

confidence: 97%

“…Low levels of BDNF are associated with neurodegenerative disorders as Parkinson's disease, multiple sclerosis or Alzheimer disease [2]. Data in medical literature related to BDNF level and its involvement in LBP is controversial, some studies revealing elevated levels of BDNF after pain-relieving methods of physical therapy [3], some others: high levels of plasma BDNF in old women with LBP compared to painfree controls [4].…”

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confidence: 99%

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Brain - Derived Neurotrophic Factor - a Marker for the Balneal Treatment of Chronic Low Back Pain?

Tica¹,

Lupu²,

Botnarciuc³

et al. 2019

Rev. Chim.

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Up till now, to our knowledge, there are no studies evaluating serum Brain - Derived Neurotrophic Factor (BDNF) levels in patients with degenerative chronic low back pain under rehabilitation treatment. BDNF is a neuroprotein associated with neuropathic pain and represents an important mediator of the effects of physical exercise. Complex balneal treatment with hot Techirghiol sapropelic mud reduces pain and increases serum levels of BDNF in these patients.

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Section: Resultscontrasting

confidence: 97%

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confidence: 99%

Brain - Derived Neurotrophic Factor - a Marker for the Balneal Treatment of Chronic Low Back Pain?

Tica¹,

Lupu²,

Botnarciuc³

et al. 2019

Rev. Chim.

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“…Interleukin‐6 (IL‐6), an inflammatory cytokine, and neuropeptide‐Y (NPY), a neuropeptide involved in pain regulation and perception, have been also associated with cLBP . Brain‐derived neurotrophic factor (BDNF), commonly studied as a pain biomarker, has also been found to be derived from IVD cells and may represent structural degradation . Many of these biochemical biomarkers have undergone limited investigation in relation to DSN with human serum and most, to our knowledge, have not been studied in a community‐based sample.…”

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confidence: 99%

Inflammatory, Structural, and Pain Biochemical Biomarkers May Reflect Radiographic Disc Space Narrowing: The Johnston County Osteoarthritis Project

Goode

Schwartz

Kraus

et al. 2019

Journal Orthopaedic Research

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The purpose of this work is to determine the relationship between biomarkers of inflammation, structure, and pain with radiographic disc space narrowing (DSN) in community-based participants. A total of 74 participants (37 cases and 37 controls) enrolled in the Johnston County Osteoarthritis Project during 2006-2010 were selected. The cases had at least mild radiographic DSN and low back pain (LBP). The controls had neither radiographic evidence of DSN nor LBP. The measured analytes from human serum included N-cadherin, Keratin-19, Lumican, CXCL6, RANTES, IL-17, IL-6, BDNF, OPG, and NPY. A standard dolorimeter measured pressure-pain threshold. The coefficients of variation were used to evaluate inter-and intra-assay reliability. Participants with similar biomarker profiles were grouped together using cluster analysis. The binomial regression models were used to estimate risk ratios (RR) and 95% confidence intervals (CI) in propensity score-matched models. Significant associations were found between radiographic DSN and OPG (RR = 3.90; 95% CI: 1.83, 8.31), IL-6 (RR = 2.54; 95% CI: 1.92, 3.36), and NPY (RR = 2.06 95% CI: 1.62, 2.63). Relative to a cluster with low levels of biomarkers, a cluster representing elevated levels of OPG, RANTES, Lumican, Keratin-19, and NPY (RR = 3.04; 95% CI: 1.22, 7.54) and a cluster representing elevated levels of NPY (RR = 2.91; 95% CI: 1.15, 7.39) were significantly associated with radiographic DSN. Clinical Significance: These findings suggest that individual and combinations of biochemical biomarkers may reflect radiographic DSN. This is just one step toward understanding the relationships between biochemical biomarkers and DSN that may lead to improved intervention delivery.

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“…The exact mechanism underlying the relationship between BDNF levels at rest and heat pain threshold is not clear. Previous clinical studies have focused on the potential negative effects of BDNF increase in chronic painful conditions (Diz et al, 2017; Garraway et al, 2003; Kerr et al, 1999; Merighi et al, 2008; Thompson et al, 1999). While the role of BDNF in the sensitization of pain pathways seems to be adaptive in the early stages of injury, it can become maladaptive in the chronic stage (Nijs et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between Plasma BDNF and Pain in Older Adults With Knee Osteoarthritis

Sorkpor

Galle

Teixeira

et al. 2021

Biological Research For Nursing

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Osteoarthritis (OA) is the most prevalent cause of chronic pain and disability in people aged ≥45 years, with the knee being the most affected joint. Neurotrophic factors like brain-derived neurotrophic factor (BDNF), which promotes neurogenesis and neuroplasticity, have been shown to significantly affect chronic pain. This study aimed to investigate the relationship between resting plasma BDNF levels and clinical pain and quantitative sensory testing measures in older adults with knee OA pain. For this secondary analysis, a previously reported dataset was used comprised of older adults with knee OA who underwent quantitative sensory testing. A comprehensive generalized linear model (GLM) was built to understand the relationships between BDNF and important covariates, followed by the elastic net (EN) method for variable selection. GLM was then performed to regress BDNF levels against only the variables selected by EN. The mean age of the sample was 60.4 years ( SD = 9.1). Approximately half of the participants were female (53%). Plasma BDNF levels were positively associated with heat pain threshold and the numeric rating scale of pain. Future mechanistic studies are needed to replicate and extend these findings to advance our knowledge of the underlying mechanisms of BDNF in knee OA and other chronic pain conditions.

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Brain-derived neurotrophic factor plasma levels are increased in older women after an acute episode of low back pain

Cited by 13 publications

References 60 publications

Brain - Derived Neurotrophic Factor - a Marker for the Balneal Treatment of Chronic Low Back Pain?

Brain - Derived Neurotrophic Factor - a Marker for the Balneal Treatment of Chronic Low Back Pain?

Inflammatory, Structural, and Pain Biochemical Biomarkers May Reflect Radiographic Disc Space Narrowing: The Johnston County Osteoarthritis Project

The Relationship Between Plasma BDNF and Pain in Older Adults With Knee Osteoarthritis

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