Abstract:Purpose: Neuroprotectants can modulate cell survival and molecular pathways common to several inherited retinal degenerations (IRD). Among them, 7,8‐dihydroxyflavone (7,8‐DHF), a brain‐derived neurotrophic factor (BDNF) mimetic, proved to rescue vision in dyeucd6 zebrafish model of IRD by upregulating BDNF–TrkB signalling [1]. A novel 7,8‐DHF structural analogue, namely OPGG‐A2, demonstrated an improved ability in restoring visual capacity. Considering these results, this work aims at evaluating long‐release d… Show more
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