Brain-derived neurotrophic factor in the infralimbic cortex alleviates inflammatory pain

Yue, Lupeng; Ma, Longyu; Cui, Shuang; Liu, Fengyu; Yi, Ming; Wan, You

doi:10.1016/j.neulet.2017.06.028

Cited by 29 publications

(24 citation statements)

References 40 publications

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“…Coronal slices (thickness, 400 μm) that contained the PL/IL cortices were then cut on a Vibroslice (1,000+, Pelco 102; Ted Pella Inc., Redding, CA). The anatomical locations of the PL/IL cortices were confirmed on the basis of a rat brain atlas (Paxinos and Watson, 2007) and have been previously reported by our laboratory [ 12 ]. Before a single slice was transferred to a submerged recording chamber, slices were incubated in an oxygenated aCSF bath at room temperature for at least 1 h. The chamber was perfused with aCSF (2–3 mL/min) using a pump (Peri-Star 291, World Precision Instruments, Sarasota, FL).…”

Section: Methodssupporting

confidence: 53%

A Context-Based Analgesia Model in Rats: Involvement of Prefrontal Cortex

Wan

et al. 2018

Neurosci. Bull.

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Cognition and pain share common neural substrates and interact reciprocally: chronic pain compromises cognitive performance, whereas cognitive processes modulate pain perception. In the present study, we established a non-drug-dependent rat model of context-based analgesia, where two different contexts (dark and bright) were matched with a high (52°C) or low (48°C) temperature in the hot-plate test during training. Before and after training, we set the temperature to the high level in both contexts. Rats showed longer paw licking latencies in trials with the context originally matched to a low temperature than those to a high temperature, indicating successful establishment of a context-based analgesic effect in rats. This effect was blocked by intraperitoneal injection of naloxone (an opioid receptor antagonist) before the probe. The context-based analgesic effect also disappeared after optogenetic activation or inhibition of the bilateral infralimbic or prelimbic sub-region of the prefrontal cortex. In brief, we established a context-based, non-drug dependent, placebo-like analgesia model in the rat. This model provides a new and useful tool for investigating the cognitive modulation of pain.

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Section: Methodssupporting

confidence: 53%

A Context-Based Analgesia Model in Rats: Involvement of Prefrontal Cortex

Wan

et al. 2018

Neurosci. Bull.

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“…However, we do not consider PL to be the only brain region that contributes to the aggravated nociceptive responses in rats with experience of chronic inflammatory pain. Other areas such as anterior cingulate cortex (ACC) and infralimbic cortex (IL), insular cortex and thalamus are densely connected with PL and undergo plastic changes in chronic pain (Obermann et al, 2009 ; Ivo et al, 2013 ; Lin, 2014 ; Zhuo, 2016 ; Yue et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

“…Following our previous protocol (Yue et al, 2017 ; Zhang C. et al, 2017 ), the rat was anesthetized with isoflurane. The plantar surface of left hindpaw was cleaned by 75% ethanol before a total of 100 μL CFA was injected intraplantarly.…”

Section: Methodsmentioning

confidence: 99%

Hypersensitivity of Prelimbic Cortex Neurons Contributes to Aggravated Nociceptive Responses in Rats With Experience of Chronic Inflammatory Pain

Fan

Liu

et al. 2018

Front. Mol. Neurosci.

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Previous experience of chronic pain causes enhanced responses to upcoming noxious events in both humans and animals, but the underlying mechanisms remain unclear. In the present study, we found that rats with complete Freund’s adjuvant (CFA)-induced chronic inflammatory pain experience exhibited aggravated pain responses to later formalin test. Enhanced neuronal activation upon formalin assaults and increased phosphorylated cAMP-response element binding protein (CREB) were observed in the prelimbic cortex (PL) of rats with chronic inflammatory pain experience, and inhibiting PL neuronal activities reversed the aggravated pain. Inflammatory pain experience induced persistent p38 mitogen-activated protein kinase (MAPK; p38) but not extracellular regulated protein kinase (ERK) or c-Jun N-terminal kinase (JNK) hyperphosphorylation in the PL. Inhibiting the p38 phosphorylation in PL reversed the aggravated nociceptive responses to formalin test and down-regulated enhanced phosphorylated CREB in the PL. Chemogenetics identified PL–periaqueductal gray (PAG) but not PL–nucleus accumbens (NAc) as a key pathway in inducing the aggravated formalin pain. Our results demonstrate that persistent hyperphosphorylation of p38 in the PL underlies aggravated nociceptive responses in rats with chronic inflammatory pain experience.

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“…Intraplantar injection of CFA induces instant thermal and mechanical hyperalgesia within 1 h; this hypersensitivity lasts for two weeks and then gradually subsides [ 24 – 26 ]. Thus, we performed sensory and motor analyses at 7 and 9 dpi, when the models showed stable mechanical allodynia.…”

Section: Methodsmentioning

confidence: 99%

Gait Assessment of Pain and Analgesics: Comparison of the DigiGait™ and CatWalk™ Gait Imaging Systems

Tian

Bai

et al. 2019

Neurosci. Bull.

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Investigation of pain requires measurements of nociceptive sensitivity and other pain-related behaviors. Recent studies have indicated the superiority of gait analysis over traditional evaluations (e.g., skin sensitivity and sciatic function index [SFI]) in detecting subtle improvements and deteriorations in animal models. Here, pain-related gait parameters, whose criteria include (1) alteration in pain models, (2) correlation with nociceptive threshold, and (3) normalization by analgesics, were identified in representative models of neuropathic pain (spared nerve injury: coordination data) and inflammatory pain (intraplantar complete Freund’s adjuvant: both coordination and intensity data) in the DigiGait™ and CatWalk™ systems. DigiGait™ had advantages in fixed speed (controlled by treadmill) and dynamic SFI, while CatWalk™ excelled in intrinsic velocity, intensity data, and high-quality 3D images. Insights into the applicability of each system may provide guidance for selecting the appropriate gait imaging system for different animal models and optimization for future pain research. Electronic supplementary material The online version of this article (10.1007/s12264-018-00331-y) contains supplementary material, which is available to authorized users.

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Brain-derived neurotrophic factor in the infralimbic cortex alleviates inflammatory pain

Cited by 29 publications

References 40 publications

A Context-Based Analgesia Model in Rats: Involvement of Prefrontal Cortex

A Context-Based Analgesia Model in Rats: Involvement of Prefrontal Cortex

Hypersensitivity of Prelimbic Cortex Neurons Contributes to Aggravated Nociceptive Responses in Rats With Experience of Chronic Inflammatory Pain

Gait Assessment of Pain and Analgesics: Comparison of the DigiGait™ and CatWalk™ Gait Imaging Systems

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