Brain-derived neurotrophic factor in mood disorders and antidepressant treatments

Ċastrén, Eero; Kojima, Masami

doi:10.1016/j.nbd.2016.07.010

Cited by 280 publications

(194 citation statements)

References 162 publications

(199 reference statements)

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“…As a precursor protein, pro-BDNF can be processed into a mature BDNF through intracellular and/or extracellular proteases [31]. BDNF belongs to the family of neurotrophic factors and is not only involved in the signaling pathways of the PFC and hippocampal dentate gyrus together with its receptor tropomyosin receptor kinase B (TrkB) but is also important in regulating neuroplasticity [32, 33].…”

Section: Molecular Mechanisms Associated With Chronic Pain and Depmentioning

confidence: 99%

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The Link between Depression and Chronic Pain: Neural Mechanisms in the Brain

et al. 2017

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Chronic pain, as a stress state, is one of the critical factors for determining depression, and their coexistence tends to further aggravate the severity of both disorders. Unfortunately, their association remains unclear, which creates a bottleneck problem for managing chronic pain-induced depression. In recent years, studies have found considerable overlaps between pain- and depression-induced neuroplasticity changes and neurobiological mechanism changes. Such overlaps are vital to facilitating the occurrence and development of chronic pain and chronic pain-induced depression. In this review, we summarized the role of neuroplasticity in the occurrence and development of the two disorders in question and explored individualized application strategies of analgesic drugs and antidepressants that have different pharmacological effects in the treatment of chronic pain-induced depression. Therefore, this review may provide new insights into the understanding of association between chronic pain and depression.

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Section: Molecular Mechanisms Associated With Chronic Pain and Depmentioning

confidence: 99%

“…The activity-dependent regulation expressed by the early BDNF is associated with neuronal plasticity [31]. The BDNF level of patients with depression has been found to be significantly reduced in several studies [116, 117].…”

Section: Antidepressant Drugs For Treating Chronic Pain-induced Dementioning

confidence: 99%

The Link between Depression and Chronic Pain: Neural Mechanisms in the Brain

et al. 2017

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“…The effect of antidepressants on BDNF expression and the role of BDNF in the treatment of MDD have been widely studied (see Castren and Kojima 2017 for a review). Interestingly, it has been shown that BDNF expression was increased in post-mortem brains of depressed patients treated with antidepressant drugs as compared to non-treated patients (Chen et al 2001; Dunham et al 2009).…”

Section: Neurotrophins and Other Growth Factorsmentioning

confidence: 99%

Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression

et al. 2018

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Depression is a major health problem with a high prevalence and a heavy socioeconomic burden in western societies. It is associated with atrophy and impaired functioning of cortico-limbic regions involved in mood and emotion regulation. It has been suggested that alterations in neurotrophins underlie impaired neuroplasticity, which may be causally related to the development and course of depression. Accordingly, mounting evidence suggests that antidepressant treatment may exert its beneficial effects by enhancing trophic signaling on neuronal and synaptic plasticity. However, current antidepressants still show a delayed onset of action, as well as lack of efficacy. Hence, a deeper understanding of the molecular and cellular mechanisms involved in the pathophysiology of depression, as well as in the action of antidepressants, might provide further insight to drive the development of novel fast-acting and more effective therapies. Here, we summarize the current literature on the involvement of neurotrophic factors in the pathophysiology and treatment of depression. Further, we advocate that future development of antidepressants should be based on the neurotrophin theory.

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“…The BDNF ability to augment neuroplasticity implies that low BDNF levels may have a role in cognitive declining observed in Alzheimer's disease, dementia (41,42), schizophrenia (43), depression (44), and bipolar disorder (45). The influence of BDNF on dopaminergic neurons may be relevant to the pathogenesis of schizophrenia and reflect the severity or the neuronal degeneration in schizophrenia (9).…”

Section: The Role Of Bdnf and Cytokines In Schizophreniamentioning

confidence: 99%