Brain-derived neurotrophic factor gene and protein expression in pediatric and adult depressed subjects

Pandey, G. N.; Dwivedi, Yogesh K.; Rizavi, Hooriyah S.; Ren, Xiaolin; Zhang, Hui; Pavuluri, Mani N.

doi:10.1016/j.pnpbp.2010.03.003

Cited by 110 publications

(59 citation statements)

References 47 publications

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“…Consistently, decreased BDNF expression levels in the lymphocytes or platelets of depressed/suicide attempters [21,47] and its association with suicide attempts and anxiety-related traits have been reported [48] .…”

Section: Discussionmentioning

confidence: 54%

Association between Sirtuin 1 Gene rs10997870 Polymorphism and Suicide Behaviors in Bipolar Disorder

et al. 2016

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Background/Aims: Suicidal behavior (SB) in bipolar disorder (BD) is a complex multifactorial event resulting from an interaction of genetic, neurobiological and psychosocial factors. Recent studies identified new possible mechanisms, suggesting a role for sirtuins (SIRTs 1-7), a family of nicotinamide adenine dinucleotide-dependent enzymes with a multifaceted role in the central nervous system. The aims of the present study were: (1) to investigate the effects of the rs10997870 SIRT1 gene variant on SB in BD; (2) to explore the effects of the same gene variant on specific depressive symptoms at the severest episode. Methods: One hundred and eighty DSM-IV bipolar outpatients were enrolled in a naturalistic cohort study. The rs10997870 polymorphism within the SIRT1 gene was analyzed. Results: An association between the GG genotype and SB was detected (lifetime: p = 0.015). Compared to other genotypes, GG carriers presented more frequently psychomotor agitation (p = 0.009) and a higher Hamilton Depression Rating Scale total score (p = 0.014) at the severest depressive episode. SB and psychomotor agitation were found to be associated with GG carriers and G allele in a multivariate analysis as well. Conclusion: Our findings suggest a role of the rs10997870 SIRT1 gene variant in SB amongst BD patients and its association with specific depressive symptoms. Despite a number of limitations of this exploratory study, our results may provide new insight into the mechanisms underlying SB in BD.

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Section: Discussionmentioning

confidence: 54%

Association between Sirtuin 1 Gene rs10997870 Polymorphism and Suicide Behaviors in Bipolar Disorder

et al. 2016

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“…Patients were excluded for the following conditions: (a) pain at another site or associated with a painful condition (eg., degenerative disc disease, herniated lumbar disc, fibromyalgia, neuropathy, rheumatoid arthritis, sciatica); (b) previous spinal surgery; (c) presence of neurological deficits; (d) history of comorbidities that affect sensorimotor function (eg., multiple sclerosis, spinal cord injury, diabetes); (e) pregnant or within 3-months postpartum; (f) taking opioid, antidepressants or anticonvulsant medication; and, (g) history of psychological disorders (major depression, bipolar disorder, schizophrenia) because of a possible associations with biological markers [34–36]. Eligibility for the healthy no-pain control group included men and women (a) between 18–50 years of age; (b) could read and write in English; (c) with no known medical, psychological problems or prescribed medication; (d) not pregnant or breastfeeding; and, (e) no recent history of pain at any location.…”

Section: Methodsmentioning

confidence: 99%

Acute Low Back Pain

Starkweather

Ramesh

Lyon

et al. 2016

The Clinical Journal of Pain

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Objectives Low back pain is the second most frequently diagnosed pain condition in the United States’ and although a majority of individuals have resolution of pain during the acute period, an estimated 40% of individuals will experience persistent pain. Given the heterogenous nature of low back pain, this study sought to describe and compare somatosensory and molecular (gene expression) profiles between individuals with acute low back pain and healthy no-pain controls Methods Using a previously established protocol, we comprehensively assessed somatosensory parameters among 31 no-pain control participants and 31 participants with acute low back pain. Samples of whole blood were drawn to examine mRNA expression of candidate genes involved in the transduction, maintenance, and modulation of pain. Results The acute low back pain group exhibited increased pain sensitivity to cold stimuli, mechanical stimuli, including mechanical temporal summation at both the painful back area and remote location suggesting a mechanism of enhanced central nervous system excitability. In addition, deep tissue specific peripheral sensitization was suggested due to significant differences in pressure pain threshold of the painful back area, but not the remote body site. Several genes that were differentially expressed were significantly associated with somatosensory alterations identified in the acute low back pain group. Discussion Acute low back pain participants showed selective pain sensitivity enhancement and differential gene expression profiles compared to pain-free controls. Further research to characterize pain-associated somatosensory changes in the context of altered mRNA expression levels may provide insight on the molecular underpinnings of maladaptive chronic pain.

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“…Platelet and serum levels have been shown to strongly correlate, while serum and plasma levels may differ as a function of the amount of BDNF released from platelets during the clotting process (Serra-Millas et al, 2011). In depression, platelet and serum BDNF levels have been consistently shown to be reduced (Lee and Kim, 2009; Pandey et al, 2010; Sen et al, 2008; Serra-Millas et al, 2011). Studies of plasma BDNF have shown both decreased and increased levels, however this may be the result of differences in assay methods employed (Serra-Millas et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…A meta-analysis of studies of serum BDNF levels in depressed patients provides strong support for decreased levels in depression and for increases with antidepressant treatment (Sen et al, 2008). Three recent studies demonstrating decreased platelet BDNF in depression (Lee and Kim, 2009; Pandey et al, 2010; Serra-Millas et al, 2011) indicate that the decreased serum levels are not simply due to the failure of platelets to release accumulated BDNF into serum. Two non-pharmacological treatments for depression, electroconvulsive therapy (ECT) and repetitive trans-cranial magnetic stimulation (rTMS) have both been shown in animal models to increase brain BDNF levels (Hashimoto, 2010).…”

Section: Introductionmentioning

confidence: 99%

Platelet protein kinase C and brain-derived neurotrophic factor levels in borderline personality disorder patients

Koenigsberg¹,

Yuan²,

Diaz³

et al. 2012

Psychiatry Research

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Borderline personality disorder (BPD) is a prevalent and difficult to treat psychiatric condition characterized by abrupt mood swings, intense anger and depression, unstable interpersonal relationships, impulsive self-destructive behavior and a suicide rate of approximately 10%. Possible underlying molecular dysregulations in BPD have not been well explored. Protein kinase C (PKC) and brain-derived neurotrophic factor (BDNF) have both been implicated in affective disorders, but their role in BPD has not been examined. Platelets were isolated from blood obtained from 24 medication-free BPD patients and 18 healthy control subjects. PKC-α, phosphorylated-PKC-α (p-PKCα), PKC-β II, and BDNF were measured in platelet homogenates by immunoblotting. In the males, platelet BDNF and PKC-α levels were lower in patients than controls. p-PKC-α and PKC-βII were lower at trend levels. In the entire sample, platelet p-PKC α and PKC-α activity were lower, at a trend level, in patients compared to controls. This is the first report to our knowledge of PKC and BDNF activity in BPD and calls for replication. These findings are consistent with altered PKC and BDNF activity in a range of neuropsychiatric conditions including bipolar disorder, depression and suicide.

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Brain-derived neurotrophic factor gene and protein expression in pediatric and adult depressed subjects

Cited by 110 publications

References 47 publications

Association between Sirtuin 1 Gene rs10997870 Polymorphism and Suicide Behaviors in Bipolar Disorder

Association between Sirtuin 1 Gene rs10997870 Polymorphism and Suicide Behaviors in Bipolar Disorder

Acute Low Back Pain

Platelet protein kinase C and brain-derived neurotrophic factor levels in borderline personality disorder patients

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