Brain-derived neurotrophic factor contributes to abdominal pain in irritable bowel syndrome

Yu, Yanbo; Zuo, Xiuli; Zhao, Qin; Chen, Fei-Xue; Yang, Jing; Dong, Yanyan; Wang, Peng; Li, Yanqing

doi:10.1136/gutjnl-2011-300265

Cited by 119 publications

(129 citation statements)

References 44 publications

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“…24 In addition, high colonic NGF levels were found in patients with irritable bowel syndrome. 25 The latter 2 conditions are frequently associated with OAB, suggesting the involvement of common pathophysiological mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Urinary Neurotrophic Factors in Healthy Individuals and Patients with Overactive Bladder

et al. 2013

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Section: Discussionmentioning

confidence: 99%

Urinary Neurotrophic Factors in Healthy Individuals and Patients with Overactive Bladder

et al. 2013

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“…In PDMs with comorbid irritable bowel syndrome, treating menstrual pain helps to relieve the pain associated with irritable bowel syndrome [54]. A role for BDNF protein in chronic pain conditions such as irritable bowel syndrome [55] and fibromyalgia [56]–[58] has been suggested. It has been postulated that BDNF protein strengthens the synaptic plasticity within the pain modulatory circuitry and contributes to descending pain facilitation and the subsequent visceral pain and hypersensitivity [50].…”

Section: Discussionmentioning

confidence: 99%

Association of Brain-Derived Neurotrophic Factor Gene Val66Met Polymorphism with Primary Dysmenorrhea

Lee

Chen

et al. 2014

PLoS ONE

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Primary dysmenorrhea (PDM), the most prevalent menstrual cycle-related problem in women of reproductive age, is associated with negative moods. Whether the menstrual pain and negative moods have a genetic basis remains unknown. Brain-derived neurotrophic factor (BDNF) plays a key role in the production of central sensitization and contributes to chronic pain conditions. BDNF has also been implicated in stress-related mood disorders. We screened and genotyped the BDNF Val66Met polymorphism (rs6265) in 99 Taiwanese (Asian) PDMs (20–30 years old) and 101 age-matched healthy female controls. We found that there was a significantly higher frequency of the Met allele of the BDNF Val66Met polymorphism in the PDM group. Furthermore, BDNF Met/Met homozygosity had a significantly stronger association with PDM compared with Val carrier status. Subsequent behavioral/hormonal assessments of sub-groups (PDMs = 78, controls = 81; eligible for longitudinal multimodal neuroimaging battery studies) revealed that the BDNF Met/Met homozygous PDMs exhibited a higher menstrual pain score (sensory dimension) and a more anxious mood than the Val carrier PDMs during the menstrual phase. Although preliminary, our study suggests that the BDNF Val66Met polymorphism is associated with PDM in Taiwanese (Asian) people, and BDNF Met/Met homozygosity may be associated with an increased risk of PDM. Our data also suggest the BDNF Val66Met polymorphism as a possible regulator of menstrual pain and pain-related emotions in PDM. Absence of thermal hypersensitivity may connote an ethnic attribution. The presentation of our findings calls for further genetic and neuroscientific investigations of PDM.

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“…Many studies were focused on the genetic polymorphisms associated with IBS. Yu and colleagues showed that the increased BDNF expression as compared with healthy controls in gut biopsies is associated with IBS [73]. On the other hand, BDNF Val66Met single nucleotide polymorphism (BDNF Val66Met SNP) was associated with decreased BDNF secretion from neurons and may lead to impairments in learning and altered susceptibility to stress [74].…”

Section: Reviewmentioning

confidence: 99%

The relationship between irritable bowel syndrome and psychiatric disorders: from molecular changes to clinical manifestations

et al. 2014

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Irritable bowel syndrome (IBS) is a functional syndrome characterized by chronic abdominal pain accompanied by altered bowel habits. Although generally considered a functional disorder, there is now substantial evidence that IBS is associated with a poor quality of life and significant negative impact on work and social domains. Neuroimaging studies documented changes in the prefrontal cortex, ventro-lateral and posterior parietal cortex and thalami, and implicate alteration of brain circuits involved in attention, emotion and pain modulation. Emerging data reveals the interaction between psychiatric disorders including generalized anxiety disorder, panic disorder, major depressive disorder, bipolar disorder, and schizophrenia and IBS, which suggests that this association should not be ignored when developing strategies for screening and treatment. Psychological, social and genetic factors appear to be important in the development of IBS symptomatology through several mechanisms: alteration of HPA axis modulation, enhanced perception of visceral stimuli or psychological vulnerability. Elucidating the molecular mechanisms of IBS with or without psychiatric comorbidities is crucial for elucidating the pathophysiology and for the identification of new therapeutical targets in IBS.

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Brain-derived neurotrophic factor contributes to abdominal pain in irritable bowel syndrome

Abstract: The increased expression of BDNF in colonic mucosa, together with the structural alterations of mucosal innervation, may contribute to the visceral hyperalgesia in IBS.

Cited by 119 publications

References 44 publications

Urinary Neurotrophic Factors in Healthy Individuals and Patients with Overactive Bladder

Urinary Neurotrophic Factors in Healthy Individuals and Patients with Overactive Bladder

Association of Brain-Derived Neurotrophic Factor Gene Val66Met Polymorphism with Primary Dysmenorrhea

The relationship between irritable bowel syndrome and psychiatric disorders: from molecular changes to clinical manifestations

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