Brain‐derived neurotrophic factor (BDNF) is required for the enhancement of hippocampal neurogenesis following environmental enrichment

Rossi, Chiara; Angelucci, Andrea; Costantin, Laura; Braschi, Chiara; Mazzantini, Mario; Babbini, Francesco; Fabbri, Maria Elena; Tessarollo, Lino; Maffei, Lamberto; Berardi, Nicoletta; Caleo, Matteo

doi:10.1111/j.1460-9568.2006.05059.x

Cited by 524 publications

(365 citation statements)

References 44 publications

(71 reference statements)

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“…EE promotes various plasticity mechanisms in the hippocampus, including bdnf gene upregulation, enhanced dendritic branching, and the stimulation of adult neurogenesis [234][235][236][237], reminiscent of our observations that CSP-TTK21 activates CBP/p300 activity. Furthermore, CBP-deficient mice present no response to the beneficial effect of EE on the induction and enhancement of spatial navigation capabilities during neurogenesis, highlighting the contribution of CBP to EE effects [233].…”

Section: Discussionsupporting

confidence: 71%

Acetyltransferases (HATs) as Targets for Neurological Therapeutics

et al. 2013

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The acetylation of histone and non-histone proteins controls a great deal of cellular functions, thereby affecting the entire organism, including the brain. Acetylation modifications are mediated through histone acetyltransferases (HAT) and deacetylases (HDAC), and the balance of these enzymes regulates neuronal homeostasis, maintaining the pre-existing acetyl marks responsible for the global chromatin structure, as well as regulating specific dynamic acetyl marks that respond to changes and facilitate neurons to encode and strengthen longterm events in the brain circuitry (e.g., memory formation). Unfortunately, the dysfunction of these finely-tuned regulations might lead to pathological conditions, and the deregulation of the HAT/HDAC balance has been implicated in neurological disorders. During the last decade, research has focused on HDAC inhibitors that induce a histone hyperacetylated state to compensate acetylation deficits. The use of these inhibitors as a therapeutic option was efficient in several animal models of neurological disorders. The elaboration of new cell-permeant HAT activators opens a new era of research on acetylation regulation. Although pathological animal models have not been tested yet, HAT activator molecules have already proven to be beneficial in ameliorating brain functions associated with learning and memory, and adult neurogenesis in wild-type animals. Thus, HAT activator molecules contribute to an exciting area of research.

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Section: Discussionsupporting

confidence: 71%

Acetyltransferases (HATs) as Targets for Neurological Therapeutics

et al. 2013

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“…This antidepressantinduced survival is lost in mice with impaired BDNF signaling (Sairanen et al, 2005). An additional study found evidence for the dependence of BDNF on the enhancement of hippocampal neurogenesis that is observed following environmental enrichment (Rossi et al, 2006).…”

Section: Bdnfmentioning

confidence: 94%

Interaction between BDNF and Serotonin: Role in Mood Disorders

Martinowich

2007

Neuropsychopharmacol

646

435

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Brain-derived neurotrophic factor (BDNF) and serotonin (5-hydroxytryptamine, 5-HT) are two seemingly distinct signaling systems that play regulatory roles in many neuronal functions including survival, neurogenesis, and synaptic plasticity. A common feature of the two systems is their ability to regulate the development and plasticity of neural circuits involved in mood disorders such as depression and anxiety. BDNF promotes the survival and differentiation of 5-HT neurons. Conversely, administration of antidepressant selective serotonin reuptake inhibitors (SSRIs) enhances BDNF gene expression. There is also evidence for synergism between the two systems in affective behaviors and genetic epitasis between BDNF and the serotonin transporter genes.

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“…Exposure of mice to an enriched environment or a running wheel increases both the spatial memory ability in the water maze and the number of adult-born neurons in DG (Kempermann et al 1997(Kempermann et al , 1998aNilsson et al 1999;van Praag et al 1999a,b;Brown et al 2003;Koo et al 2003;Rossi et al 2006;Tashiro et al 2007). In addition, both neurogenesis and spatial memory performances are improved in senescent or middle-aged mice raised in an enriched environment (Kempermann et al 1998b.…”

Section: Correlationsmentioning

confidence: 99%

Interaction between Neurogenesis and Hippocampal Memory System: New Vistas

Abrous

Wojtowicz

2015

Cold Spring Harb Perspect Biol

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During the last decade, the questions on the functionality of adult neurogenesis have changed their emphasis from if to how the adult-born neurons participate in a variety of memory processes. The emerging answers are complex because we are overwhelmed by a variety of behavioral tasks that apparently require new neurons to be performed optimally. With few exceptions, the hippocampal memory system seems to use the newly generated neurons for multiple roles. Adult neurogenesis has given the dentate gyrus new capabilities not previously thought possible within the scope of traditional synaptic plasticity. Looking at these new developments from the perspective of past discoveries, the science of adult neurogenesis has emerged from its initial phase of being, first, a surprising oddity and, later, exciting possibility, to the present state of being an integral part of mainstream neuroscience. The answers to many remaining questions regarding adult neurogenesis will come along only with our growing understanding of the functionality of the brain as a whole. This, in turn, will require integration of multiple levels of organization from molecules and cells to circuits and systems, ultimately resulting in comprehension of behavioral outcomes.

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Brain‐derived neurotrophic factor (BDNF) is required for the enhancement of hippocampal neurogenesis following environmental enrichment

Cited by 524 publications

References 44 publications

Acetyltransferases (HATs) as Targets for Neurological Therapeutics

Acetyltransferases (HATs) as Targets for Neurological Therapeutics

Interaction between BDNF and Serotonin: Role in Mood Disorders

Interaction between Neurogenesis and Hippocampal Memory System: New Vistas

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