Brain-derived neurotrophic factor (BDNF) gene polymorphisms shape cortical plasticity in humans

Antal, Andrea; Chaieb, Leila; Moliadze, Vera; Monte-Silva, Kátia; Poreisz, Csaba; Thirugnanasambandam, Nivethida; Nitsche, Michael A.; Shoukier, Moneef; Ludwig, Harald; Paulus, Walter

doi:10.1016/j.brs.2009.12.003

Cited by 212 publications

(205 citation statements)

References 37 publications

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“…Inconsistent treatment outcomes appear to be influenced by variability in individuals' responses to NIBS. Several factors have been shown to influence the reliability and effectiveness of NIBS (Ridding and Ziemann, 2010), including genetic factors (Cheeran et al, 2008, Antal et al, 2010, hormone and drug interactions (Sale et al, 2008), age (Rogasch et al, 2009;Todd et al, 2010;Bashir et al, 2014) and levels of physical activity ). Other important factors that appear critical in determining the brain's response to NIBS, and which will be discussed in detail in this review, are the site of stimulation (Fox et al, 2014) and the activity of the underlying networks during stimulation (Nitsche et al, 2003;Fregni et al, 2005;Hummel et al, 2005;Antal et al, 2007;Kujirai et al, 2006;Andrews et al, 2011).…”

Section: Brain Stimulation As a Clinical Intervention For Restoring Nmentioning

confidence: 99%

Imaging human brain networks to improve the clinical efficacy of non-invasive brain stimulation

Sale¹,

Mattingley²,

Zalesky³

et al. 2015

Neuroscience & Biobehavioral Reviews

126

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Section: Brain Stimulation As a Clinical Intervention For Restoring Nmentioning

confidence: 99%

Imaging human brain networks to improve the clinical efficacy of non-invasive brain stimulation

Sale¹,

Mattingley²,

Zalesky³

et al. 2015

Neuroscience & Biobehavioral Reviews

126

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“…Cheeran et al (2008) reported a trend for lower cortical plasticity, as determined using peripheral electric stimulation and subsequent transcranial magnetic stimulation (TMS) (Stefan et al, 2000), in BDNF Met carriers compared with Val/Val homozygotes. Likewise, others reported higher plasticity-induction in Val/Val homozygotes using short-term training and cortical mapping (Kleim et al, 2006;McHughen et al, 2010) or intermittent theta-burst stimulation (iTBS) (Antal et al, 2010). On the other hand, Antal et al (2010) found larger transcranial direct current stimulation (tDCS)-induced modulation of motor cortex excitability in Met carriers.…”

Section: Introductionmentioning

confidence: 99%

“…Likewise, others reported higher plasticity-induction in Val/Val homozygotes using short-term training and cortical mapping (Kleim et al, 2006;McHughen et al, 2010) or intermittent theta-burst stimulation (iTBS) (Antal et al, 2010). On the other hand, Antal et al (2010) found larger transcranial direct current stimulation (tDCS)-induced modulation of motor cortex excitability in Met carriers. Others failed to detect significant differences between BDNF Val66Met genotype groups for repetitive TMS-or iTBS-induced plasticity (Li Voti et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Interaction of BDNF and COMT Polymorphisms on Paired-Associative Stimulation-Induced Cortical Plasticity

Witte¹,

Kürten²,

Jansen³

et al. 2012

J. Neurosci.

101

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The common single-nucleotide polymorphism (SNP) brain-derived neurotrophic factor (BDNF) valine-to-methionine substitution at codon 66 (Val66Met) has been associated with differences in memory functions and cortical plasticity following brain stimulation. Other studies could not confirm these results, though, and potential interactions of BDNF carrier status with other learning-relevant SNPs are largely unknown. The present study aimed to evaluate the effects of BDNF Val66Met genotype on paired associative stimulation (PAS)-induced motor cortex plasticity, while additionally taking catechol-O-methyltransferase (COMT) Val158Met and kidney and brain (KIBRA) rs17070145 carrier status into account. Therefore, a cohort of 2 ϫ 16 age-and education-matched healthy young females underwent transcranial magnetic stimulation using an excitatory PAS 25 protocol to induce cortical plasticity. Cognitive performance was assessed using implicit grammar-and motor-learning tasks and a detailed neuropsychological test battery. While BDNF carrier status alone did not significantly influence PAS-induced cortical plasticity, we found a significant BDNF ϫ COMT interaction, showing higher plasticity immediately following the PAS 25 protocol for the BDNF Val/Val vs Met genotype in COMT Met homozygotes only (ANOVA, p ϭ 0.027). A similar advantage for this group was noted for implicit grammar learning (ANOVA, p ϭ 0.021). Accounting for KIBRA rs17070145 did not explain significant variance. Our findings for the first time demonstrate an interaction of BDNF by COMT on human cortical plasticity. Moreover, they show that genotype-related differences in neurophysiology translate into behavioral differences. These findings might contribute to a better understanding of the mechanisms of interindividual differences in cognition.

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“…The role of genetic variation in the after-effects of various NIBS protocols, including the BDNF Val66Met polymorphism, has been the subject of a number of recent studies. Met carriers exhibit reduced BDNF secretion and impaired performance on learning and memory (Cheeran et al, 2008;Di Lazzaro et al, 2012) or greater post-intervention increases in cortical excitability in Met carriers (Antal et al, 2010;Teo et al, 2014) including a study of older adults (Puri et al, 2015).…”

mentioning

confidence: 99%

Does transcranial direct current stimulation enhance cognitive and motor functions in the ageing brain? A systematic review and meta- analysis

Summers

Kang

Cauraugh

2016

Ageing Research Reviews

158

121

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The use of transcranial direct current stimulation (tDCS) to enhance cognitive and motor functions has enjoyed a massive increase in popularity. Modifying neuroplasticity via non-invasive cortical stimulation has enormous potential to slow or even reverse declines in functions associated with ageing. The current meta-analysis evaluated the effects of tDCS on cognitive and motor performance in healthy older adults. Of the 81 studies identified, 25 qualified for inclusion. A random effects model meta-analysis revealed a significant overall standardized mean difference equal to 0.53 (SE = 0.09; medium heterogeneity: I 2 = 57.08%; and high fail-safe: N = 448). Five analyses on moderator variables indicated significant tDCS beneficial effects: (a) on both cognitive and motor task performances, (b) across a wide-range of cognitive tasks, (c) on specific brain areas, (d) stimulation offline (before) or online (during) the cognitive and motor tasks. Although the meta-analysis revealed robust support for enhancing both cognitive and motor performance, we outline a number of caveats on the use of tDCS.

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Brain-derived neurotrophic factor (BDNF) gene polymorphisms shape cortical plasticity in humans

Cited by 212 publications

References 37 publications

Imaging human brain networks to improve the clinical efficacy of non-invasive brain stimulation

Imaging human brain networks to improve the clinical efficacy of non-invasive brain stimulation

Interaction of BDNF and COMT Polymorphisms on Paired-Associative Stimulation-Induced Cortical Plasticity

Does transcranial direct current stimulation enhance cognitive and motor functions in the ageing brain? A systematic review and meta- analysis

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