Brain-derived neurotrophic factor association with amygdala response in major depressive disorder

Lorenzetti, Valentina; Costafreda, Sergi G.; Rimmer, Rachael M.; Rasenick, Mark M.; Marangell, Lauren B.; Fu, Cynthia H.Y.

doi:10.1016/j.jad.2020.01.159

Cited by 15 publications

(12 citation statements)

References 21 publications

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“…Brain-derived neurotrophic factor (BDNF) is a neurotrophin that plays an important role in neuron survival, growth, and maintenance in key brain circuits referring to emotional and cognitive function [11]. Accumulating evidence shows that neuroplastic mechanisms dependent of BDNF are deleteriously changed in major depression and animal models of depressive disorder [12]. Nerve Growth Factor (NGF) has been discovered as a signaling molecule that is vital to survival, protection, and differentiation of sympathetic and peripheral sensory neurons [13].…”

Section: Introductionmentioning

confidence: 99%

Psychological Status, Compliance, Serum Brain-Derived Neurotrophic Factor, and Nerve Growth Factor Levels of Patients with Depression after Augmented Mindfulness-Based Cognitive Therapy

et al. 2022

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Objective. Mindfulness-based cognitive therapy (MBCT) is a cost-effective psychosocial program that prevents relapse/recurrence in major depression. The present study aimed to analyze the effects of augmented MBCT along with standard treatment dominated by pharmacotherapy on psychological state, compliance, brain-derived neurotrophic factor (BDNF), and nerve growth factor (NGF) expression levels in patients with depression. Methods. A total of 160 eligible patients with depression in The First Affiliated Hospital of Zhengzhou University were included in this study. The study randomly assigned the patients to the experimental group (n = 80) and control group (n = 80). All participants were assessed with the questionnaires including the 17-item Hamilton Depression Rating Scale (HAMD-17), Rosenberg Self-esteem Scale (RSES), Self-Acceptance Questionnaire (SAQ), and Stigma Scale (Scale of Stigma in People with Mental Illness, SSPM). The serum levels of BDNF and NGF were detected by enzyme-linked immunosorbent assay (ELISA). Results. After 8 weeks of treatment, the experimental group showed significant lower HAMD-17 score, higher RSES, and SAQ score, as well as lower SSPM score compared with the control group ( P < 0.01 ). Furthermore, ELISA revealed that the serum levels of BDNF and NGF remarkably increased in the experimental group after treatment ( P < 0.001 ). Conclusions. Our data showed that augmented MBCT combined with pharmacotherapy contributed to improvement on patients’ psychological state, compliance, and disease recurrence.

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Section: Introductionmentioning

confidence: 99%

Psychological Status, Compliance, Serum Brain-Derived Neurotrophic Factor, and Nerve Growth Factor Levels of Patients with Depression after Augmented Mindfulness-Based Cognitive Therapy

et al. 2022

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“…Given that this dataset consists of a psychiatric cohort of patients with depression, quantitative analysis was conducted on ROIs relevant to the disease. ROIs used for this analysis include the hippocampus, amygdala, temporal, and frontal lobes as they have been shown to be associated with depression 40–44 . MAPE, relative to full‐count image, was the figure of merit utilized to determine the quantitative results across dNet and U‐Net and Gaussian filtering.…”

Section: Methodsmentioning

confidence: 99%

“…ROIs used for this analysis include the hippocampus, amygdala, temporal, and frontal lobes as they have been shown to be associated with depression. [40][41][42][43][44] MAPE, relative to full-count image, was the figure of merit utilized to determine the quantitative results across dNet and U-Net and Gaussian filtering.…”

Section: J Roi Quantificationmentioning

confidence: 99%

Full‐count PET recovery from low‐count image using a dilated convolutional neural network

et al. 2020

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Purpose: Positron emission tomography (PET) is an essential technique in many clinical applications that allows for quantitative imaging at the molecular level. This study aims to develop a denoising method using a novel dilated convolutional neural network (CNN) to recover full-count images from low-count images. Methods: We adopted similar hierarchical structures as the conventional U-Net and incorporated dilated kernels in each convolution to allow the network to observe larger, more robust features within the image without the requirement of downsampling and upsampling internal representations. Our dNet was trained alongside a U-Net for comparison. Both models were evaluated using a leaveone-out cross-validation procedure on a dataset of 35 subjects (~3500 slabs), which were obtained from an ongoing 18 F-Fluorodeoxyglucose (FDG) study. Low-count PET data (10% count) were generated by randomly selecting one-tenth of all events in the associated listmode file. Analysis was done on the static image from the last 10 minutes of emission data. Both low-count PET and full-count PET were reconstructed using ordered subset expectation maximization (OSEM). Objective image quality metrics, including mean absolute percent error (MAPE), peak signal-to-noise ratio (PSNR), and structural similarity index metric (SSIM), were used to analyze the deep learning methods. Both deep learning methods were further compared to a traditional Gaussian filtering method. Further, region of interest (ROI) quantitative analysis was also used to compare U-Net and dNet architectures. Results: Both the U-Net and our proposed network were successfully trained to synthesize fullcount PET images from the generated low-count PET images. Compared to low-count PET and Gaussian filtering, both deep learning methods improved MAPE, PSNR, and SSIM. Our dNet also systematically outperformed U-Net on all three metrics (MAPE: 4.99 AE 0.68 vs 5.31 AE 0.76, P < 0.01; PSNR: 31.55 AE 1.31 dB vs 31.05 AE 1.39, P < 0.01; SSIM: 0.9513 AE 0.0154 vs 0.9447 AE 0.0178, P < 0.01). ROI quantification showed greater quantitative improvements using dNet over U-Net. Conclusion: This study proposed a novel approach of using dilated convolutions for recovering fullcount PET images from low-count PET images.

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“…94 Brain-derived neurotrophic factor is a neurotrophic factor involved in neurogenesis and neuroplasticity. 95,96 Severe hypoxia was shown to inhibit synaptic plasticity, which contributed to cell death and impaired neurogenesis. 97 However, modest episodes of hypoxia were found to exert neuroprotective effects by triggering adaptation of cells.…”

Section: Hypoxia and Hippocampal Dg Neurogenesismentioning

confidence: 99%

The role of hypoxia in stem cell regulation of the central nervous system: From embryonic development to adult proliferation

Jia

Guan

et al. 2021

CNS Neurosci Ther

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Hypoxia is involved in the regulation of various cell functions in the body, including the regulation of stem cells. The hypoxic microenvironment is indispensable from embryonic development to the regeneration and repair of adult cells. In addition to embryonic stem cells, which need to maintain their self‐renewal properties and pluripotency in a hypoxic environment, adult stem cells, including neural stem cells (NSCs), also exist in a hypoxic microenvironment. The subventricular zone (SVZ) and hippocampal dentate gyrus (DG) are the main sites of adult neurogenesis in the brain. Hypoxia can promote the proliferation, migration, and maturation of NSCs in these regions. Also, because most neurons in the brain are non‐regenerative, stem cell transplantation is considered as a promising strategy for treating central nervous system (CNS) diseases. Hypoxic treatment also increases the effectiveness of stem cell therapy. In this review, we firstly describe the role of hypoxia in different stem cells, such as embryonic stem cells, NSCs, and induced pluripotent stem cells, and discuss the role of hypoxia‐treated stem cells in CNS diseases treatment. Furthermore, we highlight the role and mechanisms of hypoxia in regulating adult neurogenesis in the SVZ and DG and adult proliferation of other cells in the CNS.

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Brain-derived neurotrophic factor association with amygdala response in major depressive disorder

Cited by 15 publications

References 21 publications

Psychological Status, Compliance, Serum Brain-Derived Neurotrophic Factor, and Nerve Growth Factor Levels of Patients with Depression after Augmented Mindfulness-Based Cognitive Therapy

Psychological Status, Compliance, Serum Brain-Derived Neurotrophic Factor, and Nerve Growth Factor Levels of Patients with Depression after Augmented Mindfulness-Based Cognitive Therapy

Full‐count PET recovery from low‐count image using a dilated convolutional neural network

The role of hypoxia in stem cell regulation of the central nervous system: From embryonic development to adult proliferation

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