Brain-derived neurotrophic factor and risk of schizophrenia: An association study and meta-analysis

Qian, Lulu; Zhao, Jian; Shi, Yongyong; Zhao, Xinzhi; Gao, Feng; Xu, Feng; Zhu, S.; He, Lin

doi:10.1016/j.bbrc.2006.12.121

Cited by 57 publications

(38 citation statements)

References 35 publications

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“…The other polymorphisms analyzed in this study (rs2030324 C/T, rs988748 G/C and rs7124442 C/T) have not been studied previously in relation to asthma. However, those SNPs have been analyzed previously in several studies in relation to psychiatric disorders such as schizophrenia [29,30,31], major depressive disorder [30], bipolar disorder [30, 32, 33], and nicotine dependence [34] yielding conflicting results both in single marker and haplotype analyses.…”

Section: Discussionmentioning

confidence: 99%

Association Analysis of Brain-Derived Neurotrophic Factor Gene Polymorphisms in Asthmatic Families

Szczepankiewicz

Rose-Zerilli

Barton

et al. 2009

Int Arch Allergy Immunol

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Background: A role for neuronal modulation of inflammation and airway hyper-responsiveness has been well described in asthma, and neurotrophins provide the link between inflammation and neuronal dysfunction. Brain-derived neurotrophic factor (BDNF) is an important mediator in this interaction. The aim of this study was to analyze the possible relationship between polymorphisms of the gene encoding BDNF and susceptibility to asthma. Methods: 341 families with at least 2 siblings with asthma were genotyped for 4 BDNF polymorphisms (rs6265, rs2030324, rs988748 and rs7124442). Results: Analysis by family-based association tests revealed no significant association between any polymorphisms analyzed and asthma susceptibility. Furthermore, BDNF polymorphism was not associated with asthma-related phenotypes such as FEV₁ % predicted, bronchial hyper-responsiveness, IgE level, asthma and atopy severity scores. Conclusions: Our results suggest that genetic variation in the BDNF gene does not contribute significantly to asthma susceptibility or severity.

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Section: Discussionmentioning

confidence: 99%

Association Analysis of Brain-Derived Neurotrophic Factor Gene Polymorphisms in Asthmatic Families

Szczepankiewicz

Rose-Zerilli

Barton

et al. 2009

Int Arch Allergy Immunol

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“…Indeed, by the fact that BDNF can be found peripherally, cross the blood brain barrier and have peripheral levels that present a strong correlation with the level of cerebrospinal fluid (Pan et al 1998), this has been used as a biomarker in clinical studies. It is involved in development, maintenance and function of the central nervous system (Yamamoto et al 1996) BDNF is the most widely distributed neurotrophic factor in the central nervous system (CNS), and performs many biological functions such as neural survival, differentiation, and plasticity (Qian et al 2007). S100B is a calcium binding protein physiologically produced and released mainly by astrocytes in CNS (Sorci et al 2010).…”

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confidence: 99%

Grape juice increases the BDNF levels but not alter the S100B levels in hippocampus and frontal cortex from male Wistar Rats

Dani

Andreazza

Gonçalves

et al. 2017

An. Acad. Bras. Ciênc.

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Several studies have shown that a high consumption of vegetables and fruits is consistently associated with a low risk of oxidative stress-induced diseases, which includes some degenerative diseases such as amyotrophic lateral sclerosis, Alzheimer and Parkinson. Therefore, the objective of this study is to verify the effects of conventional and organic grape juice in the modulation of the neurotrophic factor (BDNF) and astrocytic markers protein (S100B) in hippocampus and frontal cortex of Wistar rats. In this study, 24 male Wistar rats were divided into three groups. To the first one, it was given organic purple grape juice; to the second, conventional grape juice, while the last one received only saline. After 30 days, all rats were sacrificed and hippocampus and frontal cortex were dissected. The animals that received organic and conventional grape juice showed, in frontal cortex, an elevated BNDF levels in relation to saline group. However, S100B levels did not change. These results showed that grape juices are able to modulate important marker in brain tissue, and could be an important factor to prevent brain diseases.

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“…6 Brain-derived neurotrophic factor (BDNF) is the most widely distributed neurotrophin in the central nervous system (CNS), and performs many biological functions such as neural survival, differentiation, and plasticity. 7 Increased BDNF levels in individuals with chronic SZ on long-term treatment with antipsychotics are described. 8 Neurotrophins, antioxidant enzymes and oxidative markers have complex and reciprocal interactions.…”

Section: Introductionmentioning

confidence: 99%

Serum levels of brain-derived neurotrophic factor and thiobarbituric acid reactive substances in chronically medicated schizophrenic patients: a positive correlation

Gama

Berk

Andreazza

et al. 2008

Rev. Bras. Psiquiatr.

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Serum levels of brain-derived neurotrophic factor and thiobarbituric acid reactive substances in chronically medicated schizophrenic patients: a positive correlation Níveis séricos do fator neurotrófico derivado do cérebro e dos produtos de reação com o ácido tiobarbitúrico em pacientes com esquizofrenia cronicamente medicados: correlação positiva (r = 0,333, p = 0,009) e não mostraram correlação com os de superóxido-dismutase (r = -0,181, p = 0,166). Este último também não se correlacionou aos níveis de ácido tiobarbitúrico (r = 0,141, p = 0,284

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Brain-derived neurotrophic factor and risk of schizophrenia: An association study and meta-analysis

Cited by 57 publications

References 35 publications

Association Analysis of Brain-Derived Neurotrophic Factor Gene Polymorphisms in Asthmatic Families

Association Analysis of Brain-Derived Neurotrophic Factor Gene Polymorphisms in Asthmatic Families

Grape juice increases the BDNF levels but not alter the S100B levels in hippocampus and frontal cortex from male Wistar Rats

Serum levels of brain-derived neurotrophic factor and thiobarbituric acid reactive substances in chronically medicated schizophrenic patients: a positive correlation

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