Brain‐Derived Neurotrofic Factor and its Receptor TrkB are Present, but Segregated, Within Mature Cutaneous Pacinian Corpuscles of <scp><i>M</i></scp><i>acaca fascicularis</i>

Cabo, R.; Alonso, P.; José, I. San; Vázquez, Gorka; Pastor, Juan Francisco; Germanà, Antonino; Vega, J.A.; García‐Suárez, Olivia

doi:10.1002/ar.23050

Cited by 6 publications

(6 citation statements)

References 30 publications

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“…As far as we know the presence of the components of the neurotrophin system TrkB‐BDNF‐NT4 was never investigated in genital sensory corpuscles. Previous studies have detected TrkB in human digital Meissner corpuscles and BDNF‐TrkB in monkey Pacinian corpuscles . In our hands TrkB was only detected at residual levels while BDNF was found in glial cells.…”

Section: Discussionsupporting

confidence: 48%

Hyperplastic sensory corpuscles in nevus sebaceus of labia minora pudendi. A case report

et al. 2018

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A vulvar case of nevus sebaceus is presented. During the routine histopatological examination, attention was drawn by several corpuscular structures. Immunohistochemistry demonstrated that they were sensory corpuscles, identified respectively as Meissner-like and glomerular corpuscles. Nevertheless, compared with typical Meissner corpuscles from digital glabrous skin, Meissner-like corpuscles identified here were bigger, the axon showed an irregular course, and the lamellar cells were smaller. Regarding the glomerular corpuscles they were bigger but with a normal arrangement of the corpuscular constituents. These findings suggest that these cutaneous sensory corpuscles are part of the nevus sebaceus hamartoma.

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Section: Discussionsupporting

confidence: 48%

Hyperplastic sensory corpuscles in nevus sebaceus of labia minora pudendi. A case report

et al. 2018

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“…The specialized receptor endings may serve to mechanically magnify or filter the forces imposed on the skin. Animal studies have shown that the brain-derived neurotrophic factor (BDNF) and tyrosine receptor kinase (TrkB) are important for the development and function of mechanoreceptors (Botchkarev et al, 1999;LeMaster et al, 1999;Cabo et al, 2015).…”

Section: The Peripheral Nervous Systemmentioning

confidence: 99%

The Effects of Ageing on Tactile Function in Humans

et al. 2021

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Ageing is accompanied by a steady decline in touch sensitivity and acuity. Conversely, pleasant touch, such as experienced during a caress, is even more pleasant in old age. There are many physiological changes that might explain these perceptual changes, but researchers have not yet identified any specific mechanisms. Here, we review both the perceptual and structural changes to the touch system that are associated with ageing. The structural changes include reduced elasticity of the skin in older people, as well as reduced numbers and altered morphology of skin tactile receptors. Effects of ageing on the peripheral and central nervous systems include demyelination, which affects the timing of neural signals, as well as reduced numbers of peripheral nerve fibres. The ageing brain also undergoes complex changes in blood flow, metabolism, plasticity, neurotransmitter function, and, for touch, the body map in primary somatosensory cortex. Although several studies have attempted to find a direct link between perceptual and structural changes, this has proved surprisingly elusive. We also highlight the need for more evidence regarding age-related changes in peripheral nerve function in the hairy skin, as well as the social and emotional aspects of touch. Highlights • With age, touch sensitivity declines, and gentle touch becomes more pleasant. • Skin elasticity is reduced, and skin tactile receptors are reduced or altered. • Axonal loss and demyelination affect the amount and timing of neural signals. • The brain undergoes changes to somatotopic organisation, and many broad changes. • The link between perceptual and physiological age-related changes remains elusive.

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“…; Cabo et al. ). Therefore, we analysed whether the localization of BDNF and TrkB in mechanoreceptors varies with age.…”

Section: Introductionmentioning

confidence: 96%

Ageing of the somatosensory system at the periphery: age‐related changes in cutaneous mechanoreceptors

et al. 2019

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Decline of tactile sensation associated with ageing depends on modifications in skin and both central and peripheral nervous systems. At present, age‐related changes in the periphery of the somatosensory system, particularly concerning the effects on mechanoreceptors, remain unknown. Here we used immunohistochemistry to analyse the age‐dependent changes in Meissner's and Pacinian corpuscles as well as in Merkel cell‐neurite complexes. Moreover, variations in the neurotrophic TrkB‐BDNF system and the mechanoprotein Piezo2 (involved in maintenance of cutaneous mechanoreceptors and light touch, respectively) were evaluated. The number of Meissner's corpuscles and Merkel cells decreased progressively with ageing. Meissner's corpuscles were smaller, rounded in morphology and located deeper in the dermis, and signs of corpuscular denervation were found in the oldest subjects. Pacinian corpuscles generally showed no relevant age‐related alterations. Reduced expression of Piezo2 in the axon of Meissner's corpuscles and in Merkel cells was observed in old subjects, as well was a decline in the BDNF‐TrkB neurotrophic system. This study demonstrates that cutaneous Meissner's corpuscles and Merkel cell‐neurite complexes (and less evidently Pacinian corpuscles) undergo morphological and size changes during the ageing process, as well as a reduction in terms of density. Furthermore, the mechanoprotein Piezo2 and the neurotrophic TrkB‐BDNF system are reduced in aged corpuscles. Taken together, these alterations might explain part of the impairment of the somatosensory system associated with ageing.

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Brain‐Derived Neurotrofic Factor and its Receptor TrkB are Present, but Segregated, Within Mature Cutaneous Pacinian Corpuscles of Macaca fascicularis

Cited by 6 publications

References 30 publications

Hyperplastic sensory corpuscles in nevus sebaceus of labia minora pudendi. A case report

Hyperplastic sensory corpuscles in nevus sebaceus of labia minora pudendi. A case report

The Effects of Ageing on Tactile Function in Humans

Ageing of the somatosensory system at the periphery: age‐related changes in cutaneous mechanoreceptors

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