Brain-derived endothelial cells are neuroprotective in a chronic cerebral hypoperfusion mouse model
Yuichi Matsui,
Fumitaka Muramatsu,
Hajime Nakamura
et al.
Abstract:Whether organ-specific regeneration is induced by organ-specific endothelial cells (ECs) remains unelucidated. The formation of white matter lesions due to chronic cerebral hypoperfusion causes cognitive decline, depression, motor dysfunction, and even acute ischemic stroke. Vascular ECs are an important target for treating chronic cerebral hypoperfusion. Brain-derived ECs transplanted into a mouse chronic cerebral hypoperfusion model showed excellent angiogenic potential. They were also associated with reduci… Show more
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