Brain delivery of vasoactive intestinal peptide enhanced with the nanoparticles conjugated with wheat germ agglutinin following intranasal administration

Gao, Xiaoling; Wu, Bingxian; Zhang, Qizhi; Chen, Jun; Zhu, Jiaan; Zhang, Weiwei; Rong, Zhengxin; Chen, Hongzhuan; Jiang, Xinguo

doi:10.1016/j.jconrel.2007.05.026

Cited by 194 publications

(104 citation statements)

References 37 publications

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“…20 WGA-modified nanoparticles could also be delivered to the brain after intranasal administration via the nose-brain transport pathway. 21 Since the pathogenesis of AD is in the central nervous system (CNS), the use of CL-conjugated LIP (CL/LIP) modified with WGA (WGA-CL/LIP) may benefit AD management.…”

Section: Introductionmentioning

confidence: 99%

Wheat germ agglutinin-conjugated liposomes incorporated with cardiolipin to improve neuronal survival in Alzheimer’s disease treatment

Kuo¹,

Lin²,

Li³

et al. 2017

IJN

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Curcumin (CRM) and nerve growth factor (NGF) were entrapped in liposomes (LIP) with surface wheat germ agglutinin (WGA) to downregulate the phosphorylation of kinases in Alzheimer’s disease (AD) therapy. Cardiolipin (CL)-conjugated LIP carrying CRM (CRM-CL/LIP) and also carrying NGF (NGF-CL/LIP) were used with AD models of SK-N-MC cells and Wistar rats after an insult with β-amyloid peptide (Aβ). We found that CRM-CL/LIP inhibited the expression of phosphorylated p38 (p-p38), phosphorylated c-Jun N-terminal kinase (p-JNK), and p-tau protein at serine 202 and prevented neurodegeneration of SK-N-MC cells. In addition, NGF-CL/LIP could enhance the quantities of p-neurotrophic tyrosine kinase receptor type 1 and p-extracellular signal-regulated kinase 5 for neuronal rescue. Moreover, WGA-grafted CRM-CL/LIP and WGA-grafted NGF-CL/LIP significantly improved the permeation of CRM and NGF across the blood–brain barrier, reduced Aβ plaque deposition and the malondialdehyde level, and increased the percentage of normal neurons and cholinergic activity in the hippocampus of AD rats. Based on the marker expressions and in vivo evidence, current LIP carriers can be promising drug delivery systems to protect nervous tissue against Aβ-induced apoptosis in the brain during the clinical management of AD.

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Section: Introductionmentioning

confidence: 99%

Wheat germ agglutinin-conjugated liposomes incorporated with cardiolipin to improve neuronal survival in Alzheimer’s disease treatment

Kuo¹,

Lin²,

Li³

et al. 2017

IJN

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“…For example, chitosan modified molecules showed much longer residency time on the olfactory epithelium (Charlton et al 2007), as well as enhanced permeability due to their interaction with tight junction complexes (Smith et al 2004). Additionally, PEG coated nanoparticles showed increased diffusion in tissues (Lai et al 2007), and lectins isolated from plants could greatly upregulate the uptake of coated nanoparticles without clear evidences of toxicity (Gao et al 2006;Gao et al 2007). It is hoped that other small molecules and peptides, such as cholera toxin subunit B (CTB) (Zhang et al 2008), could provide more possibilities in further improvement of nanoparticles based intranasal drug delivery.…”

Section: Intranasal Deliverymentioning

confidence: 99%

Recent advances in nanotechnology based drug delivery to the brain

et al. 2010

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Drug delivery into the brain was difficult due to the existence of blood brain barrier, which only permits some molecules to pass through freely. In past decades, nanotechnology has enabled many technical advances including drug delivery into the brain with high efficiency and accuracy. In the present paper, we summarize recent important advances in employing nanotechnology for drug delivery to the brain as well as controlled drug release.

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“…10 However, low permeability across the In addition, wheat germ agglutinin (WGA) has distinct carbohydrate specificity and can be efficient in delivery of pharmaceuticals across the blood-brain barrier. 21 In a lectin-mediated targeting study, WGA was found to have a strong interaction with human ECV304, a human bladder carcinoma-derived epithelial cell line for mimicking the blood-brain barrier, and to generate only a slight variation in glycosylation pattern. 22 The aim of this study was to investigate the ability of WGA-conjugated and CL-incorporated liposomes (WGA-CL-liposomes) to encapsulate nerve-inductive NGF and antiinflammatory CUR for AD therapy.…”

Section: Introductionmentioning

confidence: 99%

Rescuing apoptotic neurons in Alzheimer’s disease using wheat germ agglutinin-conjugated and cardiolipin-conjugated liposomes with encapsulated nerve growth factor and curcumin

Kuo¹,

Lin²

2015

IJN

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Liposomes with cardiolipin (CL) and wheat germ agglutinin (WGA) were developed to permeate the blood–brain barrier and treat Alzheimer’s disease. WGA-conjugated and CL-incorporated liposomes (WGA-CL-liposomes) were used to transport nerve growth factor (NGF) and curcumin (CUR) across a monolayer of human brain-microvascular endothelial cells regulated by human astrocytes and to protect SK-N-MC cells against apoptosis induced by β-amyloid 1–42 (Aβ 1–42 ) fibrils. An increase in the CL mole percentage in lipids increased the liposomal diameter, absolute zeta potential value, entrapment efficiency of NGF and CUR, release of NGF, biocompatibility, and viability of SK-N-MC cells with Aβ 1–42 , but decreased the atomic ratio of nitrogen to phosphorus and release of CUR. In addition, an increase in the WGA concentration for grafting enhanced the liposomal diameter, atomic ratio of nitrogen to phosphorus, and permeability of NGF and CUR across the blood–brain barrier, but reduced the absolute zeta potential value and biocompatibility. WGA-CL-liposomes carrying NGF and CUR could be promising colloidal delivery carriers for future clinical application in targeting the blood–brain barrier and inhibiting neurotoxicity.

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Brain delivery of vasoactive intestinal peptide enhanced with the nanoparticles conjugated with wheat germ agglutinin following intranasal administration

Cited by 194 publications

References 37 publications

Wheat germ agglutinin-conjugated liposomes incorporated with cardiolipin to improve neuronal survival in Alzheimer’s disease treatment

Wheat germ agglutinin-conjugated liposomes incorporated with cardiolipin to improve neuronal survival in Alzheimer’s disease treatment

Recent advances in nanotechnology based drug delivery to the brain

Rescuing apoptotic neurons in Alzheimer’s disease using wheat germ agglutinin-conjugated and cardiolipin-conjugated liposomes with encapsulated nerve growth factor and curcumin

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Brain delivery of vasoactive intestinal peptide enhanced with the nanoparticles conjugated with wheat germ agglutinin following intranasal administration

Cited by 194 publications

References 37 publications

Wheat germ agglutinin-conjugated liposomes incorporated with cardiolipin to improve neuronal survival in Alzheimer&rsquo;s disease treatment

Wheat germ agglutinin-conjugated liposomes incorporated with cardiolipin to improve neuronal survival in Alzheimer&rsquo;s disease treatment

Recent advances in nanotechnology based drug delivery to the brain

Rescuing apoptotic neurons in Alzheimer&rsquo;s disease using wheat germ agglutinin-conjugated and cardiolipin-conjugated liposomes with encapsulated nerve growth factor and curcumin

Contact Info

Product

Resources

About

Wheat germ agglutinin-conjugated liposomes incorporated with cardiolipin to improve neuronal survival in Alzheimer’s disease treatment

Wheat germ agglutinin-conjugated liposomes incorporated with cardiolipin to improve neuronal survival in Alzheimer’s disease treatment

Rescuing apoptotic neurons in Alzheimer’s disease using wheat germ agglutinin-conjugated and cardiolipin-conjugated liposomes with encapsulated nerve growth factor and curcumin