Brain delivery of buspirone hydrochloride chitosan nanoparticles for the treatment of general anxiety disorder

Bari, Naimat Kalim; Fazil, Mohammad; Hassan, Quamrul; Haider, Rafi; Gaba, Bharti; Narang, Jasjeet Kaur; Baboota, Sanjula; Ali, Javed

doi:10.1016/j.ijbiomac.2015.07.041

Cited by 58 publications

(37 citation statements)

References 47 publications

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“…There are various particulate drug delivery systems either on the market or in the pipelines [ 1 ]. Different nanocarriers can be used, for example polymeric, lipid and inorganic nanoparticles [ 138 ]. Agents as chitosan, hydroxypropylcellulose, carboxymethylcellulose, and carbopol display mucoadhesive properties, but also hyaluronic acid and polyacrylic acid are well suited [ 137 ].…”

Section: Formulations Dosage Forms and Medical Devices For Intranmentioning

confidence: 99%

“…Agents as chitosan, hydroxypropylcellulose, carboxymethylcellulose, and carbopol display mucoadhesive properties, but also hyaluronic acid and polyacrylic acid are well suited [ 137 ]. Hassan et al showed that thiolated chitosan particles doubled the brain delivery of the anxiety disorder treatment drug buspirone hydrochloride [ 138 ]. As chitosan is a highly mucophilic agent, high concentrations can even lead to mucus gel break down what in turn leads to an easy access for the drug to epithelial cells.…”

Section: Formulations Dosage Forms and Medical Devices For Intranmentioning

confidence: 99%

“…As chitosan is a highly mucophilic agent, high concentrations can even lead to mucus gel break down what in turn leads to an easy access for the drug to epithelial cells. But it has to be considered that mucus gel break down also impacts pathogen defence [ 86 , 138 ].…”

Section: Formulations Dosage Forms and Medical Devices For Intranmentioning

confidence: 99%

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Tailoring Formulations for Intranasal Nose-to-Brain Delivery: A Review on Architecture, Physico-Chemical Characteristics and Mucociliary Clearance of the Nasal Olfactory Mucosa

2018

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The blood-brain barrier and the blood-cerebrospinal fluid barrier are major obstacles in central nervous system (CNS) drug delivery, since they block most molecules from entering the brain. Alternative drug delivery routes like intraparenchymal or intrathecal are invasive methods with a remaining risk of infections. In contrast, nose-to-brain delivery is a minimally invasive drug administration pathway, which bypasses the blood-brain barrier as the drug is directed from the nasal cavity to the brain. In particular, the skull base located at the roof of the nasal cavity is in close vicinity to the CNS. This area is covered with olfactory mucosa. To design and tailor suitable formulations for nose-to-brain drug delivery, the architecture, structure and physico-chemical characteristics of the mucosa are important criteria. Hence, here we review the state-of-the-art knowledge about the characteristics of the nasal and, in particular, the olfactory mucosa needed for a rational design of intranasal formulations and dosage forms. Also, the information is suitable for the development of systemic or local intranasal drug delivery as well as for intranasal vaccinations.

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Section: Formulations Dosage Forms and Medical Devices For Intranmentioning

confidence: 99%

Section: Formulations Dosage Forms and Medical Devices For Intranmentioning

confidence: 99%

See 1 more Smart Citation

Tailoring Formulations for Intranasal Nose-to-Brain Delivery: A Review on Architecture, Physico-Chemical Characteristics and Mucociliary Clearance of the Nasal Olfactory Mucosa

2018

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“…Barthelmes nanoparticles (TCS-NPs) of buspirone hydrochloride (BUH) for delivery into the brain through the intranasal route using bovine nasal cavity tissue. It was found that TCS-NPs had 15% more binding efficiency than unmodified CS-NPs, which could be due to the low amount of CS and TCS interacting with mucin, increased particle size of BUH-loaded CS and TCS nanoparticles and absorption of drug molecules on the NP surface, leading to low NP mucosal layer penetration [27]. Improved TCS binding efficiency could be due to covalent attachment of TGA to CS generating a thiol group that interacts with mucin [37].…”

Section: Microparticles and Nanoparticlesmentioning

confidence: 99%

“…The formulation (i.e. TCS-BUH-NPs) was also tested in vivo in Wistar rats: a comparatively higher brain concentration (797.46 ± 35.76 ng/ml; tmax 120 min) was achieved after intranasal administration of TCS-NPs compared with that achieved after nasal administration of the pure drug solution (417.77 ± 19.24 ng/ml; tmax 60 min), as shown in the figure 3b [27] .…”

Section: Microparticles and Nanoparticlesmentioning

confidence: 99%

Thiomers and their potential applications in drug delivery

Shah

Dilawar

et al. 2016

Expert Opinion on Drug Delivery

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Thiomers are the product of the immobilization of sulfhydryl-bearing ligands onto the polymer backbone of a conventional polymer, which results in a significant improvement in mucoadhesion; in situ gelation and efflux inhibition compare with unchanged polymers. Because of thiol groups, thiomers have more reactivity and enhanced protection against oxidation. Since the late 1990s, extensive work has been conducted on these promising polymeric excipients in the pharmaceutical field. Areas covered: This review covers thiomers, their classification and their different properties. Various techniques for the synthesis, purification and characterization of thiomers are described in detail. This review also encompasses their various properties such as mucoadhesion, permeation enhancement, in situ gelation and efflux inhibition, as well as different formulations based on thiomers. In addition to the use of thiomers as multifunctional excipients, this review also encompasses their use as drugs. Expert opinion: The synthesis is realized by linkage of sulfhydryl-bearing ligands but reported methods give low yields. Higher degrees of modification are not necessary and would probably lead to extreme changes in properties. Nevertheless, an accurate characterization of the final product is important. The scale-up procedure for industrial manufacturing has been adapted to produce GMP materials; Lacrimera® eye drops have already entered the European market.

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Thiolated Nanoparticles for Biomedical Applications: Mimicking the Workhorses of Our Body

Hock¹,

Racaniello

Aspinall

et al. 2021

Advanced Science

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Advances in nanotechnology have generated a broad range of nanoparticles (NPs) for numerous biomedical applications. Among the various properties of NPs are functionalities being related to thiol substructures. Numerous biological processes that are mediated by cysteine or cystine subunits of proteins representing the workhorses of the bodies can be transferred to NPs. This review focuses on the interface between thiol chemistry and NPs. Pros and cons of different techniques for thiolation of NPs are discussed. Furthermore, the various functionalities gained by thiolation are highlighted. These include overall bio-and mucoadhesive, cellular uptake enhancing, and permeation enhancing properties. Drugs being either covalently attached to thiolated NPs via disulfide bonds or being entrapped in thiolated polymeric NPs that are stabilized via inter-and intrachain crosslinking can be released at the diseased tissue or in target cells under reducing conditions. Moreover, drugs, targeting ligands, biological analytes, and enzymes bearing thiol substructures can be immobilized on noble metal NPs and quantum dots for therapeutic, theranostic, diagnostic, biosensing, and analytical reasons. Within this review a concise summary and analysis of the current knowledge, future directions, and potential clinical use of thiolated NPs are provided.

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Brain delivery of buspirone hydrochloride chitosan nanoparticles for the treatment of general anxiety disorder

Cited by 58 publications

References 47 publications

Tailoring Formulations for Intranasal Nose-to-Brain Delivery: A Review on Architecture, Physico-Chemical Characteristics and Mucociliary Clearance of the Nasal Olfactory Mucosa

Tailoring Formulations for Intranasal Nose-to-Brain Delivery: A Review on Architecture, Physico-Chemical Characteristics and Mucociliary Clearance of the Nasal Olfactory Mucosa

Thiomers and their potential applications in drug delivery

Thiolated Nanoparticles for Biomedical Applications: Mimicking the Workhorses of Our Body

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