Brain death hormone therapy and Graft survival: A systematic review of the literature

Latifi, Marzieh; Bagherpour, Farzaneh; Rahban, Habib; Pourhossein, Elahe; Dehghani, Sanaz

doi:10.1016/j.tpr.2022.100098

Cited by 1 publication

(1 citation statement)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Brain death is a medico-legal term that describes the irreversible loss of function of the brainstem and the brain in whole. Brain death can mostly be diagnosed clinically and/or with an apnea test 1 . Early diagnosis of brain death is important to expedite organ transplantation, provide closure for loved ones, and prevent unnecessary negative medical interventions and when possible expedite organ transplantation 2 .…”

Section: Introductionmentioning

confidence: 99%

Association between red blood cell distribution width and the prognosis of brain death in patients with a Glasgow Coma Scale < 6

Latifi,

Rahban,

Pourhosein

et al. 2023

Sci Rep

View full text Add to dashboard Cite

Red blood cell distribution width (RDW) has been reported as a meaningful prognostic factor in various diseases. Our study compared patients’ RDW levels and prognosis at admission and discharge time. A total of 128 patients 77 patients who suffered brain death (subject group), and 51 patients who were discharged from the hospital (control group) with GCS ≤ 6 were recruited from 60 hospitals for this study. Demographical data and RDW measurements in these patients at admission time and brain death/discharge time were extracted into two groups. 46 (35.9%) patients were females and 82 patients (64.1%) were males with a median age of 36 years old. A significant difference in baseline characteristics of GCS (P < 0.001), RDW at admission time (P < 0.001), and RDW at discharge or brain death time (P < 0.001) were noted between the two groups. In the overall population, RDW at admission time had a median value of 13.75% and was positively correlated with gender (P < 0.04, rs = 0.582) and age (P < 0.023, rs = − 0.201). Initially, there were no significant differences in RDW upon admission. However, upon discharge, although the RDW in the control group was not significant (P < 0. 1), the RDW level at the time of brain death was notably 0.45 fold higher (P = 0.001) compared to the time of admission. The standardized residuals at the two-time points showed an approximately normal distribution. The most effective RDW cut-off in Brain death was determined as 14.55. Based on the findings, using RDW as a prognostic factor has a sensitivity of 0.468 and a specificity of 0.137 in diagnosing brain death. RDW biomarker is a simple and inexpensive laboratory test that may be seen as a valuable perspective for initial patient evaluation. RDW is a powerful marker for the prognosis of brain death in patients with a GCS ≤ 6 at admission time, in order to identify a subset of patients who may require more aggressive management in the trauma center.

show abstract

Section: Introductionmentioning

confidence: 99%