Brain Changes in the White Matter of the Brain White Matter Changes and Cognitive Functions in Asymptomatic Patients

Бердалин, А. Б.; Nikogosova, A. K.; Gubskiy, Ilya; Ковражкина, Е. А.; Gubskiy, L.V.; Lelyuk, V. G.

doi:10.1007/s10517-020-04942-2

Cited by 4 publications

(2 citation statements)

References 9 publications

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“…Степень атрофии структур лимбической системы оценивали по шкале MTA (Medial temporal lobe atrophy score) [11]. При анализе состояния белого вещества головного мозга применяли шкалу Fazekas [12].…”

Section: материал и методыunclassified

State of intra- and extracranial arteries, white matter and cerebral cortex in asymptomatic hypertensive patients

Бердалин

Vishnyakova

Gubsky

et al. 2021

Cardiovasc Ther Prev

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Aim. To assess the state of intra- and extracranial arteries, white matter and cerebral cortex in asymptomatic hypertensive (HTN) patients according to multimodal examination.Material and methods. The study included data from 147 asymptomatic individuals (without prior ischemic stroke) with an established HTN (n=43; 29,3%) and without it. All participants underwent extracranial duplex ultrasound, transcranial duplex sonography, detection of middle cerebral artery microembolism, and brain magnetic resonance imaging. We performed a statistical analysis of the data obtained, adjusted for age and body mass index.Results. In patients with HTN, atherosclerotic plaques were more often detected — 37,2 vs 14,4% on the right (p=0,027) and 41,9 vs 13,5% on the left (p=0,001). In these patients, intima-media abnormalities and common carotid artery narrowing were also more common. Regional temporal lobe atrophy (p=0,044 on the right and p=0,046 on the left), central atrophy (p=0,045), focal periventricular white matter abnormalities (p=0,004) were more pronounced in hypertensive patients. There was no association between HTN and the presence of cerebral microbleeds, as well as the Montreal Cognitive Assessment (MoCA) score.Conclusion. In asymptomatic hypertensive patients relative to those without HTN, with comparable body mass index and age, head arterial abnormalities are more pronounced, but this regards only large ones — the common carotid artery. In these patients, more pronounced white matter and cerebral cortex changes were revealed.

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Section: материал и методыunclassified

State of intra- and extracranial arteries, white matter and cerebral cortex in asymptomatic hypertensive patients

Бердалин

Vishnyakova

Gubsky

et al. 2021

Cardiovasc Ther Prev

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“…Asymptomatic cerebral lesions can also have clinical significance and affect the patient's cognitive status. 2,3 Despite the fact that carotid artery stenting (CAS) is a minimally invasive procedure, intraoperative cerebral embolism remains the main problem and can increase the risk of symptomatic and asymptomatic ischemic foci of the brain. It has been established that there is an association between microemboli during carotid revascularization and ipsilateral new brain lesions.…”

Section: Introductionmentioning

confidence: 99%

Impact of shaggy aorta on intraoperative cerebral embolism during carotid artery stenting

Osipova

Bugurov

Saaya

et al. 2022

Preprint

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Background: Careful selection of patients for carotid stenting is necessary. We suggest that patients with a shaggy aorta syndrome may have a higher risk of perioperative embolic complications. Methods: The study is a subanalysis of the SIBERIA Trial. We included 72 patients undergoing transfemoral carotid artery stenting. All patients had an MRI DWI and a clinical neurological examination two days before and on the second and 30th days after the intervention. Results: 46 patients had shaggy aorta syndrome. Intraoperative embolisms were recorded in 82.6% and 46.1% of patients with and without shaggy aorta syndrome, respectively (p=0.001). New asymptomatic ischemic brain lesions in the postoperative period occurred in 78.3% and in 26.9% of patients with and without shaggy aorta syndrome, respectively (p=0.000). 3 (6.5%) cases of stroke within 30 days after the procedure were observed only in patients with shaggy aorta syndrome. Shaggy aorta syndrome (OR 5.54 [1.83:16.7], p=0.001) and aortic arch ulceration (OR 6.67 [1.19: 37.3], p = 0.02) were independently associated with cerebral embolism. Shaggy aorta syndrome (OR 9.77 [3.14-30.37], p=0.000) and aortic arch ulceration (OR 12.9 [2.3: 72.8], p = 0.003) were independently associated with ipsilateral new asymptomatic ischemic brain lesions. Conclusions: Shaggy aorta syndrome and aortic arch ulceration significantly increase the odds of intraoperative embolism and new asymptomatic ischemic brain lesions. Carotid endarterectomy or transcervical carotid stent should be selected in the presence of aortic ulceration.

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Interrelations of Cerebral Hemodynamics with Parameters of Cardiac Function and Brain Tissue in Patients with Ischemic Stroke

et al. 2021

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Brain Changes in the White Matter of the Brain White Matter Changes and Cognitive Functions in Asymptomatic Patients

Cited by 4 publications

References 9 publications

State of intra- and extracranial arteries, white matter and cerebral cortex in asymptomatic hypertensive patients

State of intra- and extracranial arteries, white matter and cerebral cortex in asymptomatic hypertensive patients

Impact of shaggy aorta on intraoperative cerebral embolism during carotid artery stenting

Interrelations of Cerebral Hemodynamics with Parameters of Cardiac Function and Brain Tissue in Patients with Ischemic Stroke

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