Brain cancer diagnosis and therapy with nanoplatforms☆

Encapsulation of methylene blue in polyacrylamide nanoparticle platforms protects its photodynamic effectiveness

“…The photodynamic mechanism of free photosensitizers in general is fundamentally different from the work presented in this paper and the previous reports on our NPs [17][18][19][20][21]. As illustrated by the minimal enzymatic reduction of the encapsulated MB discussed above, the polymeric matrix of the NPs should be capable of protecting the embedded photosensitizers from direct interaction with biological macromolecules in vivo.…”

“…As illustrated in the in vitro studies above, encapsulated MB permits not only sufficient light-stimulated generation of 1 O 2 , but also adequate diffusion out of the matrix to cause damage to the tumor cells. Furthermore, based on recent successful in vivo work with the similar polyacrylamide-based NPs, using the less efficient photofrin [17][18][19][20], rather than MB, as the PDT agent, we expect the MB-containing polyacrylamide NPs to be equally or more efficient in in vivo targeted treatment of glioma. Fluorescence emission at 680 nm vs time (after subtraction of photobleaching for both curves): (A) 3 mg/mL MB-containing NPs and (B) 1 μg/mL MB, respectively, when mixed in PBS (pH 7.2) with 0.45 μmol NADH and 0.05 mg diaphorase.…”

“…In recent years, with the advancement of nanotechnology, engineered nanoparticles have received attention as a possible means of encapsulating and delivering PDT agents. Research in our laboratories [17][18][19][20][21][22] and elsewhere [23,24] has demonstrated the utility of nano-structured materials, which employ biocompatible nanoparticle matrices encapsulated with efficient photo-active molecules, for PDT. Our concept of a nanoparticle platform (NP) was initiated by the design of Photonic Explorers for Biomedical use by Biologically Localized Embedding, termed PEBBLEs.…”

Nanoparticular Drug Delivery Systems in the Treatment Central Nervous System Diseases: Review

“…Klinik deneyler "Gliadel wafer" ların yaşam süre-sini artırdığını ve ileri seviye gliomaların semptomlarını radyoterapi ve ameliyattan daha etkin bir şekilde kontrol ettiğini göstermiştir. 45 Beyne ilaç uygulanması için denenen yöntem-lerden biri de kraniyotomidir. Bu yöntem kafa böl-gesinde bir delik açma ve etken maddeleri bu yol aracılığı ile beyne ulaştırma esasına dayanmaktadır.…”

The role of peptides in blood‐brain barrier nanotechnology

“…The development of nanoplatforms requires a multidisciplinary team of engineers, physicists, chemists, cell biologists, pharmacologists, and others. Several good reviews of nanoplatforms have recently appeared, which introduce the idea of a nanoplatform [39] cover the topic from different perspectives [40][41][42][43][44][45][46] and numerous patents on nanoplatforms have also been registered.…”