Brain cancer and occupational exposure to magnetic fields among men: results from a Canadian population-based case-control study

Villeneuve, Paul J.; Agnew, David A.; Johnson, Kenneth C.; Mao, Yang

doi:10.1093/ije/31.1.210

Cited by 67 publications

(48 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Electrical fields are much more effectively shielded by the dielectric properties of water-rich tissues than MFs. An analysis of five recent studies has demonstrated a modest increase of risk for leukemia and brain cancer in electric utility workers from France, Canada, and the United States (36,70,85). Furthermore, a list of suspected field-induced cancer types including male breast cancer and malignant melanoma has been put forward (66).…”

Section: Physiological Effects Of Mf Exposurementioning

confidence: 99%

Cellular target of weak magnetic fields: ionic conduction along actin filaments of microvilli

Gartzke

Lange²

2002

American Journal of Physiology-Cell Physiology

102

View full text Add to dashboard Cite

Gartzke, Joachim, and Klaus Lange. Cellular target of weak magnetic fields: ionic conduction along actin filaments of microvilli. Am J Physiol Cell Physiol 283: C1333-C1346, 2002; 10.1152/ajpcell. 00167.2002.-The interaction of weak electromagnetic fields (EMF) with living cells is a most important but still unresolved biophysical problem. For this interaction, thermal and other types of noise appear to cause severe restrictions in the action of weak signals on relevant components of the cell. A recently presented general concept of regulation of ion and substrate pathways through microvilli provides a possible theoretical basis for the comprehension of physiological effects of even extremely low magnetic fields. The actin-based core of microfilaments in microvilli is proposed to represent a cellular interaction site for magnetic fields. Both the central role of F-actin in Ca 2ϩ signaling and its polyelectrolyte nature eliciting specific ion conduction properties render the microvillar actin filament bundle an ideal interaction site for magnetic and electric fields. Ion channels at the tip of microvilli are connected with the cytoplasm by a bundle of microfilaments forming a diffusion barrier system. Because of its polyelectrolyte nature, the microfilament core of microvilli allows Ca 2ϩ entry into the cytoplasm via nonlinear cable-like cation conduction through arrays of condensed ion clouds. The interaction of ion clouds with periodically applied EMFs and field-induced cation pumping through the cascade of potential barriers on the F-actin polyelectrolyte follows well-known physical principles of ion-magnetic field (MF) interaction and signal discrimination as described by the stochastic resonance and Brownian motor hypotheses. The proposed interaction mechanism is in accord with our present knowledge about Ca 2ϩ signaling as the biological main target of MFs and the postulated extreme sensitivity for coherent excitation by very low field energies within specific amplitude and frequency windows. Microvillar F-actin bundles shielded by a lipid membrane appear to function like electronic integration devices for signal-tonoise enhancement; the influence of coherent signals on cation transduction is amplified, whereas that of random noise is reduced. calcium signaling; cell differentiation; Brownian motor hypothesis; cyclotron resonance; hair cell; mechanoelectrical coupling; physiological effects MORE THAN A DECADE OF RESEARCH on field effects in biological systems has yielded rather compelling data for the involvement of the Ca 2ϩ signaling pathway as a primary and main target of magnetic fields (MFs). As first demonstrated by Liburdy and colleagues (52,53) and later on by a number of other authors, the Ca 2ϩ influx pathways of isolated or cultured cells are severely affected by rather low MF energies.The physiological relevance of this finding is high, because Ca 2ϩ represents the most important intracellular signal governing almost all physiological functions in differentiated cells. Most importantly, cytopla...

show abstract

Section: Physiological Effects Of Mf Exposurementioning

confidence: 99%

Cellular target of weak magnetic fields: ionic conduction along actin filaments of microvilli

Gartzke

Lange²

2002

American Journal of Physiology-Cell Physiology

102

View full text Add to dashboard Cite

show abstract

“…A Canadian study suggested that the risk association could be stronger for more aggressive forms, which was judged consistent with the hypothesis that magnetic fields act at the promotional stage. 17 If so, the risk we found in our study could be underestimated.…”

Section: Discussionmentioning

confidence: 67%

Occupational and residential exposure to electromagnetic fields and risk of brain tumors in adults: A case–control study in Gironde, France

Baldi

Coureau

Jaffré

et al. 2011

Intl Journal of Cancer

View full text Add to dashboard Cite

The etiology of brain tumors remains largely unknown. Among potential risk factors, exposure to electromagnetic fields is suspected. We analyzed the relationship between residential and occupational exposure to electromagnetic field and brain tumors in adults. A case-control study was carried out in southwestern France between May 1999 and April 2001. A total of 221 central nervous system tumors (105 gliomas, 67 meningiomas, 33 neurinomas and 16 others) and 442 individually ageand sex-matched controls selected from general population were included. Electromagnetic field exposure [extremely low frequency (ELF) and radiofrequency separately was assessed in occupational settings through expert judgement based on complete job calendar, and at home by assessing the distance to power lines with the help of a geographical information system. Confounders such as education, use of home pesticide, residency in a rural area and occupational exposure to chemicals were taken into account. Separate analyses were performed for gliomas, meningiomas and acoustic neurinomas. A nonsignificant increase in risk was found for occupational exposure to electromagnetic fields [odds ratio (OR 5 1.52, 0.92-2.51)]. This increase became significant for meningiomas, especially when considering ELF separately [OR 5 3.02; 95 percent confidence interval (95% CI) 51. 10-8.25]. The risk of meningioma was also higher in subjects living in the vicinity of power lines (<100 m), even if not significant (OR 5 2.99, 95% CI 0.86-10.40). These data suggest that occupational or residential exposure to ELF may play a role in the occurrence of meningioma.

show abstract

“…Too few studies have presented results for histologic subtypes of brain cancer to draw firm conclusions, although some have shown stronger associations with gliomas 3 , and a more recent study reported a more pronounced risk for glioblastoma multiforme. 26 In conclusion, in our population-based, nested case-control study, we found moderately elevated ORs for exposure to residential magnetic fields and brain tumours but no clear exposureresponse pattern. The results, however, are not consistent with our findings for occupational exposure, where the analysis showed an inverse association.…”

mentioning

confidence: 51%

Residential and occupational exposure to 50‐Hz magnetic fields and brain tumours in Norway: A population‐based study

Klæboe

Blaasaas

Haldorsen

et al. 2005

Intl Journal of Cancer

View full text Add to dashboard Cite

Our case‐control study was conducted to investigate whether residential and occupational exposure to magnetic fields increased the risk for brain tumours in adults. Data from an occupational exposure matrix was also evaluated. The study population in this nested case‐control study was made up of subjects aged 16 years and older who had resided in a broad corridor around a high‐voltage power line in 1980 or during one of the years from 1986–1996. The cases were incident cases diagnosed during 1980–96. Two controls were matched to each case by year of birth, sex, municipality and first year entering the cohort. The time‐weighted average exposure to residential magnetic fields generated by the power lines was calculated for the exposure follow‐up from 1 January 1967 to diagnosis. In addition, job titles and branches of industry were classified as categories of hours per week in a magnetic field above background level (0.1 μT). Exposures were cumulated over occupationally active years for the exposure follow‐up from 1 January 1955 to diagnosis. When residential magnetic fields are evaluated, the 2 upper residential, time‐weighted, average magnetic field categories showed elevated odds ratios (ORs) for all brain tumours (OR = 1.6; 95% confidence interval [95%CI] 0.9–2.7 and OR = 1.3; 95% CI 0.7–2.3). Occupational exposure showed no association to exposure for any site. We found an elevated risk for residential exposure to magnetic fields and brain tumours, although the risk was not significant, and no clear exposure‐response pattern was found. The findings for the occupational exposure groups showed an inverse association. © 2005 Wiley‐Liss, Inc.

show abstract

Brain cancer and occupational exposure to magnetic fields among men: results from a Canadian population-based case-control study

Abstract: Our findings support the hypothesis that occupational magnetic field exposure increases the risk of glioblastoma multiforme.

Cited by 67 publications

References 32 publications

Cellular target of weak magnetic fields: ionic conduction along actin filaments of microvilli

Cellular target of weak magnetic fields: ionic conduction along actin filaments of microvilli

Occupational and residential exposure to electromagnetic fields and risk of brain tumors in adults: A case–control study in Gironde, France

Residential and occupational exposure to 50‐Hz magnetic fields and brain tumours in Norway: A population‐based study

Contact Info

Product

Resources

About