Brain biopsy in the diagnosis of cerebral mycosis fungoides

Abstract

SUMMARY A case of cerebral mycosis fungoides co-existing with progressive multifocal leucoencephalopathy presented with dementia. Brain biopsy established the diagnosis of mycosis fungoides after cerebrospinal fluid examinations and computerised tomographic scanning of the brain produced non-specific abnormalities.Mycosis fungoides is a cutaneous lymphoma with characteristic histological and cytological features.' Visceral infiltration is a common necropsy finding and although the nervous system usually is spared,'-5 metastatic involvement of many parts of the nervous system and various non-metastatic neurological complications have been described (table). Cytological examination of the CSF has been helpful in

Thinking about CNS metastasis in cutaneous lymphoma: Analysis of existing data

“…After review, 48 articles were included in our analyses ( Fig. 1 ) [3] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [54] , [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] .

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Progressive multifocal leucoencephalopathy in a patient with Sézary syndrome

“…Moreover, the lack of effective JCV‐specific CD4 help may impair the functionality of anti‐JCV‐specific memory CD8 T cells 4 . Three cases of PML have previously been described with mycosis fungoides, a nonleukaemic CTCL; two of these patients received chemotherapy, the third had a cerebral metastatic infiltration 5–7 . PML cases in HIV seronegative patients have been reported in chronic lymphocytic leukaemia, and in patients receiving monoclonal antibodies such as natalizumab, rituximab or more recently efalizumab in psoriasis 8 .…”

T Cell Receptor γ-Chain Gene Polymerase Chain Reaction to Diagnose Central Nervous System Involvement by Cutaneous T Cell Lymphoma

“…2 Symptoms arise as early as 4 months and as late as 30 years from the time of initial diagnosis, with mean time to onset described as 3.8 years to 7.5 years. 2,3 Pre-mortem diagnosis is usually made by cerebrospinal fluid (CSF) cytology, although cytology is often negative and the diagnosis is made at autopsy. 2,4 Brain biopsy is an alternative diagnostic method.…”

“…2,4 Brain biopsy is an alternative diagnostic method. 3,5 We describe a patient who developed gait abnormalities, mental status changes, and brain magnetic resonance (MR) imaging abnormalities 6 years after the initial diagnosis of CTCL. Cytology was repeatedly negative, flow cytometry was inconclusive, and a brain biopsy was not performed because there was no discrete lesion for biopsy.…”