Brain bioenergetics in chronic hypertension: Risk factor for acute ischemic stroke

Ferrari, Francesca; Federico, Villa Roberto

doi:10.1016/j.bcp.2022.115260

Cited by 8 publications

(3 citation statements)

References 164 publications

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“…Mitochondria are energy production centers within cells, and high blood pressure also can cause mitochondrial dysfunction, resulting in damage to the nervous system and aggravate ischemic stroke. 49 Our results indicated hypertension were significantly associated with the incidence of ischemic stroke even after adjusting confounders in multivariate analysis. A hypertensive person was 3.161 times more likely to have ischemic stroke than a non-hypertensive person.…”

Section: Discussionmentioning

confidence: 54%

Risk factors for ischemic stroke in China: a case-control study

Xu,

Eng Hwa,

Bin Nordin

et al. 2024

F1000Res

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Background Stroke is a primary cause of disability and death in adults worldwide. This study aimed to determine whether uric acid (UA), total bilirubin (TBIL), serum creatinine (Scr), homocysteine (Hcy), platelet large cell ratio (P-LCR), mean platelet volume (MPV), red blood cell volume distribution width (RDW), and common carotid artery intima-media thickness (CCA-IMT) were risk factors for ischemic stroke and whether there were sex differences in their associations. Methods This was a case-control study, and all data were collected from the medical records at Fuzhou First People’s Hospital of Jiangxi Province, China. The case group consisted of 400 patients treated for ischemic stroke at the Neurology Department, Fuzhou First People’s Hospital from January 2017 to June 2023. The control group included 200 patients with non-ischemic stroke in the same period and at the same hospital. In this study, clinical history, physical examination, and biochemical indices such as UA, TBIL, Scr, Hcy, P-LCR, MPV, and RDW were obtained from the patients’ medical records. Craniocerebral imaging was performed using magnetic resonance imaging (MRI) or computerized tomography (CT). CCA-IMT was measured using ultrasonography of the carotid arteries. Results In the multivariate binary logistic regression analysis, Hcy, FBS, right CCA-IMT and Hypertension were associated with ischemic stroke (p<0.001). The odds of ischemic stroke increased with Hcy (adjusted OR=1.217, 95% CI=1.129-1.311, p<0.001), fasting blood sugar (FBS) (adjusted OR=1.313, 95%CI=1.169-1.475, p<0.001), and right CCA-IMT (adjusted OR=45.273, 95%CI=6.693-306.232, p<0.001). Hypertensive persons had a higher possibility of ischemic stroke than persons without hypertension (adjusted OR=3.161, 95%CI=2.086-4.790, p<0.001). Conclusions Hcy, FBS, right CCA-IMT, and hypertension are independent risk factors for ischemic stroke in China. There was no association between TBIL, Scr, P-LCR, MPV, RDW, and the incidence of ischemic stroke. There was no sex difference in the association between Hcy, TBIL, Scr, P-LCR, and the incidence of ischemic stroke.

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Section: Discussionmentioning

confidence: 54%

Risk factors for ischemic stroke in China: a case-control study

Xu,

Eng Hwa,

Bin Nordin

et al. 2024

F1000Res

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“…This may give rise to what has been termed the "reverse Robin Hood" phenomenon, whereby vasodilators, given in an attempt to improve collateral flow, may lower blood pressure, and hence CPP, thus "stealing" blood flow from the penumbra, where the need is greatest (the poor), and increasing flow to other non-ischemic brain regions (the rich), which already have plenty (Alexandrov et al, 2007). Note that mechanisms such as inflammation (Eldahshan et al, 2019), alterations in energy metabolism (Ferrari and Villa, 2022) may also impair autoregulation. Readers are directed to Claassen et al (2021) for a compressive review of autoregulation physiology and pathophysiology.…”

Section: Potential Consequences Of Icp Elevation Post-stroke Collat...mentioning

confidence: 99%

Intracranial pressure elevation post-stroke: Mechanisms and consequences

Hood

Beard²,

McLeod³

et al. 2023

Front. Stroke

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Intracranial pressure (ICP) elevation post-stroke has long been thought of as a cause of secondary deterioration after large, malignant infarction, and dramatic ICP elevation is frequently a pre-terminal event. However, there is an increasing body of evidence to suggest that ICP also rises after small stroke, typically within 24 h of the infarct. The timing of this rise suggests that it may play an important role in the collateral failure associated with early infarct expansion. Despite its increasingly recognized importance to patient outcome, very little is currently known about the underlying mechanisms of ICP elevation post-stroke. The traditional understanding suggests ICP elevation occurs solely due to cerebral edema, however this does not seem to be the case in mild-moderate infarction. Instead, recent studies suggest a role for changes in cerebrospinal fluid (CSF) volume. In this article, we will discuss recent mechanistic observations, as well as the consequences of ICP elevation post-stroke.

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“…At present, traditional risk factors have been found to be hypertension, hyperglycemia, hyperlipidemia, smoking, atrial fibrillation, hyperlipidemia, obesity, and so on. [2][3][4] In addition, timely diagnosis of blood system diseases is also very important for the timely and appropriate treatment of stroke patients. 5 The study found that although the prevalence of IS improved with the implementation of preventive measures targeting these traditional risk factors, the risk of recurrence remained.…”

Section: Introductionmentioning

confidence: 99%

Genetic Variants of CYP4F2 Associated with Ischemic Stroke Susceptibility in the Han Population from Southern China

Huang¹,

Ma²,

Lu³

et al. 2023

PGPM

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Background The pathophysiological mechanism of ischemic stroke is complex. Traditional risk factors cannot fully or only partially explain the occurrence and development of IS. Genetic factors are getting more and more attention. Our study aimed to explore the association between CYP4F2 gene polymorphism and susceptibility to IS. Methods A total of 1322 volunteers were enrolled to perform an association analysis through SNPStats online software. Using FPRP (false-positive report probability) to detect whether the result is a noteworthy finding. The interaction of SNP-SNP in IS risk was assessed by multi-factor dimensionality reduction. Statistical analysis of this study was mainly completed by SPSS 22.0 software. Results Mutant allele “A” (OR = 1.24) and genotype “AA” (OR = 1.49) or “GA” (OR = 1.26) of CYP4F2- rs2108622 are risk genetic factors for IS. Rs2108622 is significantly associated with an increased risk of IS among subjects who are females, aging >60 years old, with BMI ≥24 kg/m 2 , and smoking or drinking volunteers. CYP4F2 -rs3093106 and -rs3093105 are associated with susceptibility to IS among smoking, drinking subjects, or IS patients complicated with hypertension. Conclusion CYP4F2 -rs2108622, -rs3093106, and -rs3093105 are associated with an increased risk of IS.

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Brain bioenergetics in chronic hypertension: Risk factor for acute ischemic stroke

Cited by 8 publications

References 164 publications

Risk factors for ischemic stroke in China: a case-control study

Risk factors for ischemic stroke in China: a case-control study

Intracranial pressure elevation post-stroke: Mechanisms and consequences

Genetic Variants of CYP4F2 Associated with Ischemic Stroke Susceptibility in the Han Population from Southern China

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