Brain behavior and immunity: Twenty years of T cells

Moynihan, Jan A.; F, Santiago

doi:10.1016/j.bbi.2007.06.010

Cited by 14 publications

(7 citation statements)

References 48 publications

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“…This system is more dynamic, responding to potential pathogens and toxins upon exposure. Both systems work together to achieve homeostasis, and importantly, disruption in either can affect neuronal development and functioning (170). Optimal immune functioning is characterized by the homeostatic maintenance of the innate and acquired immune responses, balancing pro- and anti-inflammatory signaling in response to potential pathogenic threats.…”

Section: Meta-synthesis Of Theories Underlying Common Medical Comorbimentioning

confidence: 99%

Characterizing the Interplay Between Autism Spectrum Disorder and Comorbid Medical Conditions: An Integrative Review

et al. 2019

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Co-occurring medical disorders and associated physiological abnormalities in individuals with autism spectrum disorder (ASD) may provide insight into causal pathways or underlying biological mechanisms. Here, we review medical conditions that have been repeatedly highlighted as sharing the strongest associations with ASD—epilepsy, sleep, as well as gastrointestinal and immune functioning. We describe within each condition their prevalence, associations with behavior, and evidence for successful treatment. We additionally discuss research aiming to uncover potential aetiological mechanisms. We then consider the potential interaction between each group of conditions and ASD and, based on the available evidence, propose a model that integrates these medical comorbidities in relation to potential shared aetiological mechanisms. Future research should aim to systematically examine the interactions between these physiological systems, rather than considering these in isolation, using robust and sensitive biomarkers across an individual's development. A consideration of the overlap between medical conditions and ASD may aid in defining biological subtypes within ASD and in the development of specific targeted interventions.

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Section: Meta-synthesis Of Theories Underlying Common Medical Comorbimentioning

confidence: 99%

Characterizing the Interplay Between Autism Spectrum Disorder and Comorbid Medical Conditions: An Integrative Review

et al. 2019

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“…The brain is composed of different cell types of which several have the potential to present antigens and to induce an alloimmune response. The presence of T and NK cells has been demonstrated in numerous rodent and human studies [32, 33] and the autoimmunity of the brain has been well described [33]. Finally, the stereotactic surgical procedure in NPC transplantation induces a breach of the haemato‐encephalic barrier and, as a consequence, is thought to contribute to local inflammation.…”

Section: Discussionmentioning

confidence: 99%

Neural progenitors derived from human embryonic stem cells are targeted by allogeneic T and natural killer cells

Preynat‐Seauve

Rham

Tirefort

et al. 2009

J Cellular Molecular Medi

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Neural progenitor cells (NPC) of foetal origin or derived from human embryonic stem cells (HESC) have the potential to differentiate into mature neurons after transplantation into the central nervous system, opening the possibility of cell therapy for neurodegenerative disorders. In most cases, the transplanted NPC are genetically unrelated to the recipient, leading to potential rejection of the transplanted cells. Very few data provide reliable information as to the potential immune response of allogeneic neural progenitors derived from HESC. In this study, we analyzed in vitro the allogeneic immune response of T lymphocytes and natural killer (NK) cells to NPC derived from HESC or of foetal origin. We demonstrate that NPC induce T-cell stimulation and a strong NK cytotoxic response. NK-cell activity is unrelated to MHC-I expression but driven by the activating NKG2D receptor. Cyclosporine and dexamethasone previously used in clinical studies with foetal NPC did not only fail to prevent NK alloreactivity but strongly inhibited the terminal maturation from NPC into mature neurons. We conclude that allogenic transplantation of NPC in the central nervous system will most likely require an immunosuppressive regimen targeting allogenic T and NK cells, whereas possible interference with the differentiation of NPC needs to be carefully evaluated.

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“…During the last twenty years experimental findings have indicated reciprocal communication between the immune and nervous systems, where 5-HT has been proven to have important modulatory effects [1][2][3][4][5]. Enterochromaffin cells of the gastrointestinal tract are the main producers of 5-HT.…”

Section: Role Of Serotonin As a Regulator Of Immune Responsementioning

confidence: 99%

Immunomodulatory effects of fluoxetine: A new potential pharmacological action for a classic antidepressant drug?

Rosso

Palumbo

Genaro

2016

Pharmacological Research

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Selective serotonin reuptake inhibitors are frequently used antidepressants. In particular, fluoxetine is usually chosen for the treatment of the symptoms of depression, obsessive-compulsive, panic attack and bulimia nervosa. Antidepressant therapy has been associated with immune dysfunction. However, there is contradictory evidence about the effect of fluoxetine on the immune system. Experimental findings indicate that lymphocytes express the serotonin transporter. Moreover it has been shown that fluoxetine is able to modulate the immune function through a serotonin-dependent pathway and through a novel independent mechanism. In addition, several studies have shown that fluoxetine can alter tumor cell viability. Thus, it was recently demonstrated in vivo that chronic fluoxetine treatment inhibits tumor growth by increasing antitumor T-cell activity. Here we briefly review some of the literature referring to how fluoxetine is able to modify, for better or worse, the functionality of the immune system. These results of our analysis point to the relevance of the novel pharmacological action of this drug as an immunomodulator helping to treat several pathologies in which immune deficiency and/or deregulation is present.

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Brain behavior and immunity: Twenty years of T cells

Cited by 14 publications

References 48 publications

Characterizing the Interplay Between Autism Spectrum Disorder and Comorbid Medical Conditions: An Integrative Review

Characterizing the Interplay Between Autism Spectrum Disorder and Comorbid Medical Conditions: An Integrative Review

Neural progenitors derived from human embryonic stem cells are targeted by allogeneic T and natural killer cells

Immunomodulatory effects of fluoxetine: A new potential pharmacological action for a classic antidepressant drug?

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