Brain Awareness Week, CoVID-19 infection and Neurological Sciences

Federico, Antonio

doi:10.1007/s10072-020-04338-0

Cited by 11 publications

(9 citation statements)

References 16 publications

(16 reference statements)

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“…On the contrary, a lack of contact due to social distancing may create feelings of stress, anxiety, and depression. Declining mental health can exacerbate the risks for exacerbating symptoms of or negative outcomes associated with substance use disorders, as well as for declining function in those with various neurodegenerative diseases, such as Alzheimer’s disease (Federico 2020 ; Singh et al 2020 ). Since March 2020, a large shift to support a socially-distanced lifestyle has developed rapidly: University and high school education adopted various online platforms.…”

Section: Social and Societal Considerationsmentioning

confidence: 99%

The Natural History, Pathobiology, and Clinical Manifestations of SARS-CoV-2 Infections

Machhi

Herskovitz

Senan

et al. 2020

J Neuroimmune Pharmacol

497

459

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of coronavirus disease 2019 (COVID-19). SARS-CoV-2, is a positive-sense single-stranded RNA virus with epithelial cell and respiratory system proclivity. Like its predecessor, SARS-CoV, COVID-19 can lead to life-threatening disease. Due to wide geographic impact affecting an extremely high proportion of the world population it was defined by the World Health Organization as a global public health pandemic. The infection is known to readily spread from person-to-person. This occurs through liquid droplets by cough, sneeze, hand-to-mouth-to-eye contact and through contaminated hard surfaces. Close human proximity accelerates SARS-CoV-2 spread. COVID-19 is a systemic disease that can move beyond the lungs by bloodbased dissemination to affect multiple organs. These organs include the kidney, liver, muscles, nervous system, and spleen. The primary cause of SARS-CoV-2 mortality is acute respiratory distress syndrome initiated by epithelial infection and alveolar macrophage activation in the lungs. The early cell-based portal for viral entry is through the angiotensin-converting enzyme 2 receptor. Viral origins are zoonotic with genomic linkages to the bat coronaviruses but without an identifiable intermediate animal reservoir. There are currently few therapeutic options, and while many are being tested, although none are effective in curtailing the death rates. There is no available vaccine yet. Intense global efforts have targeted research into a better understanding of the epidemiology, molecular biology, pharmacology, and pathobiology of SARS-CoV-2. These fields of study will provide the insights directed to curtailing this disease outbreak with intense international impact. Keywords Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Coronavirus disease 2019 (COVID-19). Acute respiratory distress syndrome (ARDS). Angiotensin-converting enzyme 2 (ACE-2)

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Section: Social and Societal Considerationsmentioning

confidence: 99%

The Natural History, Pathobiology, and Clinical Manifestations of SARS-CoV-2 Infections

Machhi

Herskovitz

Senan

et al. 2020

J Neuroimmune Pharmacol

497

459

View full text Add to dashboard Cite

show abstract

“…Este estudio ha analizado la opinión de responsables de servicios de neurología sobre como considera que puede cambiar la asistencia, docencia e investigación neurológica en los próximos años como consecuencia de la pandemia, así como la imagen de la especialidad. Aunque algunos especialistas en Neurología de otros países han expresado su opinión en blogs o en medios de comunicación de asociaciones (21,22) , es la primera vez que se utiliza un modelo de consenso de expertos clave para ello. Los propios participantes han expresado en las encuestas que sus opiniones pueden estar modificadas por aspectos que no se conocen, como la duración de la pandemia, si aparecerá un síndrome neurológico Covid19, si la enfermedad quedará residual en la sociedad, etc.…”

Section: Discussionunclassified

¿Va a cambiar la neurología tras la pandemia de COVID-19 en los próximos 5 años? Estudio de enfoque mediante informadores clave

et al. 2020

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“…Furthermore, when present, neurological manifestation of COVID-19 infection has been categorized as CNS and peripheral nervous system (PNS) symptoms. CNS symptoms consist of headache, dizziness, impaired consciousness, and even, acute cerebrovascular disease (14,(22)(23)(24)(25)(26). PNS symptoms may consist of hyposmia, hypoplasia, neuralgia, and hypogeusia.…”

Section: Clinical Characteristicsmentioning

confidence: 99%

SAMHD1 as the Potential Link Between SARS-CoV-2 Infection and Neurological Complications

Khan

Sergi

2020

Front. Neurol.

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The recent pandemic of coronavirus infectious illness 2019 (COVID19) triggered by SARS-CoV-2 has rapidly spread around the globe, generating in severe events an acute, highly lethal pneumonia and death. In the past two hitherto similar CoVs, the severe acute respiratory syndrome CoV (SARS-CoV-1) and Middle East respiratory syndrome CoV (MERS-CoV) also gained universal attention as they produced clinical symptoms similar to those of SARS-CoV-2 utilizing angiotensin-converting enzyme 2 (ACE2) receptor and dipeptidyl peptidase 4 (DPP4) to go into the cells. COVID-19 may also present with overtly neurological symptoms. The proper understanding of the expression and dissemination of ACE2 in central and peripheral nerve systems is crucial to understand better the neurological morbidity caused by COVID-19. Using the STRING bioinformatic tool and references through text mining tools associated to Coronaviruses, we identified SAMHD1 as the probable link to neurological symptoms. Paralleled to the response to influenza A virus and, specifically, respiratory syncytial virus, SARS-CoV-2 evokes a response that needs robust induction of a subclass of cytokines, including the Type I and, obviously, Type III interferons as well as a few chemokines. We correlate ACE2 to the pathogenesis and neurologic complications of COVID-19 and found that SAMHD1 links to NF-κB pathway. No correlation was found with other molecules associated with Coronavirus infection, including ADAR, BST2, IRF3, IFITM3, ISG15, MX1, MX2, RNASEL, RSAD2, and VPRBP. We suggest that SAMHD1 is the molecule that may be behind the mechanisms of the neurological complications associated with COVID-19.

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Brain Awareness Week, CoVID-19 infection and Neurological Sciences

Cited by 11 publications

References 16 publications

The Natural History, Pathobiology, and Clinical Manifestations of SARS-CoV-2 Infections

The Natural History, Pathobiology, and Clinical Manifestations of SARS-CoV-2 Infections

¿Va a cambiar la neurología tras la pandemia de COVID-19 en los próximos 5 años? Estudio de enfoque mediante informadores clave

SAMHD1 as the Potential Link Between SARS-CoV-2 Infection and Neurological Complications

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