Brain Asymmetry: Switching from Left to Right

Lin, Shin-Yi; Burdine, Rebecca D.

doi:10.1016/j.cub.2005.04.026

Cited by 5 publications

(4 citation statements)

References 18 publications

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“…Bizarrely, the asymmetry of wristwatch-wearing behavior does indeed correlate with situs inversus (McManus et al, 2004). Recent work in zebrafish (Concha et al, 2003;Gamse et al, 2003;Halpern et al, 2003;Barth et al, 2005;Lin and Burdine, 2005;McManus, 2005) has shed light on the regulation of brain asymmetry by known pathways, but it is unclear whether the fish or another available model system will provide a tractable entry point to the study of the fascinating brain asymmetry in man as distinct from the cardiac-visceral pathways.…”

Section: Brain Asymmetrymentioning

confidence: 99%

Is the early left‐right axis like a plant, a kidney, or a neuron? The integration of physiological signals in embryonic asymmetry

Levin¹

2006

Birth Defects Research Pt C

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Embryonic morphogenesis occurs along three orthogonal axes. While the patterning of the anterior-posterior and dorsal-ventral axes has been increasingly well-characterized, the left-right (LR) axis has only relatively recently begun to be understood at the molecular level. The mechanisms that ensure invariant LR asymmetry of the heart, viscera, and brain involve fundamental aspects of cell biology, biophysics, and evolutionary biology, and are important not only for basic science but also for the biomedicine of a wide range of birth defects and human genetic syndromes. The LR axis links biomolecular chirality to embryonic development and ultimately to behavior and cognition, revealing feedback loops and conserved functional modules occurring as widely as plants and mammals. This review focuses on the unique and fascinating physiological aspects of LR patterning in a number of vertebrate and invertebrate species, discusses several profound mechanistic analogies between biological regulation in diverse systems (specifically proposing a nonciliary parallel between kidney cells and the LR axis based on subcellular regulation of ion transporter targeting), highlights the possible importance of early, highly-conserved intracellular events that are magnified to embryo-wide scales, and lays out the most important open questions about the function, evolutionary origin, and conservation of mechanisms underlying embryonic asymmetry.

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Section: Brain Asymmetrymentioning

confidence: 99%

Is the early left‐right axis like a plant, a kidney, or a neuron? The integration of physiological signals in embryonic asymmetry

Levin¹

2006

Birth Defects Research Pt C

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“…Therefore, structural composition of the brain as well as other organs on SI individuals has a minimal impact on learning abilities. [8] However, relationship in the society and diseases such as congenital heart diseases associated with SI individuals can be factors that affect their learning ability.…”

Section: Discussionmentioning

confidence: 99%

“…[7] While in many species every typical individual are asymmetrical in a similar course, animals with finish reflect inversion of situs inversus. Along these lines, while it is conceivable to devise conceivable transformative explanations behind why living beings may be asymmetric in any case (ideal pressing, liquid progression, amplifying surface range of tubes, and so on [8] There is no undeniable purpose behind why they ought to all be asymmetric to a similar bearing. It is, all things considered, much less demanding to envision a formative system for creating anti-symmetry.…”

Section: Literature Reviewmentioning

confidence: 99%

Structural and Functional Brain Asymmetries in Mirror Image People

AlJumah¹

2017

Journal of Medical and Pharmaceutical Sciences

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It is routine for most people to salute their flag by placing their hands on their hearts. However, not every person has this capability because some people are born with a reversed position of the heart as well as other organs in the body. Thus, as for the human brain, separate functions tend to be restricted within the left as well as right hemispheres. Language ability mainly occurs in the left hemisphere. However, there are other unique cases where the structure of the organs appears to be having a different location from how it appears normally. This disorder is called situs inversus abbreviated as SI and it is rare among people Aim: To explore the difference in learning abilities as between SI individuals and normal individuals. Besides, the it also examines factors affecting the learning abilities of the SI individuals. Methods: SI group individuals were compared with the normal individuals to identify the disparity between these two groups. Besides, field data was collected on the views of SI individual in the society to identify the perception regarding their rare condition in the society. Results: 8 of 16 participants were SI positive and they showed low gamma readings in hemispheres of their brains. Language ability is controlled by left hemisphere in all the participants. Conclusion: Despite SI individuals showing a different structural brain as well as other organ composition in the body, they have equal learning abilities. The disparity emanates from other social factors affecting their incorporation in the society.

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“…Asymmetry is a basic human brain organizational principle, reflected in anatomical and functional differences between the left and right hemispheres [1][2][3] . Lateralized brain development is already observed early on during fetal development 4 , and perturbations in asymmetry have been associated with several psychiatric conditions, such as autism spectrum disorder 5,6 .…”

Section: Mainmentioning

confidence: 99%

The universe is asymmetric, the mouse brain too

Rivera-Olvera,

Houwing,

Ellegood

et al. 2023

Preprint

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Hemispheric brain asymmetry is a basic organizational principle of the human brain and has been implicated in various psychiatric conditions, including autism spectrum disorder. Brain asymmetry is not a uniquely human feature and is observed in other species such as the mouse. Yet, asymmetry patterns are generally nuanced, and substantial sample sizes are required to detect these patterns. In this pre-registered study, we use a mouse dataset from the Province of Ontario Neurodevelopmental Network, which comprises structural MRI data from over 2000 mice, including genetic models for autism spectrum disorder, to reveal the scope and magnitude of hemispheric asymmetry in the mouse. Our findings demonstrate the presence of robust hemispheric asymmetry in the mouse brain, such as larger right hemispheric volumes towards the anterior pole and larger left hemispheric volumes toward the posterior pole, opposite to what has been shown in humans. This suggests the existence of species-specific traits. Further clustering analysis identified distinct asymmetry patterns in autism spectrum disorder models, a phenomenon that is also seen in atypically developing participants. Our study shows potential for the use of mouse models in studying the biological bases of typical and atypical brain asymmetry but also warrants caution as asymmetry patterns seem to differ between humans and mice.

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Brain Asymmetry: Switching from Left to Right

Abstract: The relationship between structural and functional asymmetries in the brain remains unclear. A recent report describes a zebrafish mutant that provides us with some enticing clues about this relationship.

Cited by 5 publications

References 18 publications

Is the early left‐right axis like a plant, a kidney, or a neuron? The integration of physiological signals in embryonic asymmetry

Is the early left‐right axis like a plant, a kidney, or a neuron? The integration of physiological signals in embryonic asymmetry

Structural and Functional Brain Asymmetries in Mirror Image People

The universe is asymmetric, the mouse brain too

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