Brain aromatase: Roles in reproduction and neuroprotection

ROSELLI, C

doi:10.1016/j.jsbmb.2007.05.014

Cited by 109 publications

(82 citation statements)

References 109 publications

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“…Forlano and Bass, 2005b), paralleling the known data for mammals (e.g. Roselli, 2007). Thus, the development of the testicular gland and concomitant surge in gonadal androgens may be the key factor inducing both the morphologic and behavioral changes associated with tactic transition.…”

Section: Brain Aromatase Activitysupporting

confidence: 74%

“…In vertebrates, it is well established that aromatase plays a key role both in sexual differentiation and in the expression of reproductive behaviors (e.g. Ball and Balthazart, 2004;Baum, 2003;Roselli, 2007;Forlano et al, 2006). In fish, two aromatase isoforms have been described, one preferentially expressed in the ovary (coded by the CYP19a gene) and one preferentially expressed in the brain (coded by the CYP19b gene) (e.g.…”

Section: Introductionmentioning

confidence: 99%

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Brain and gonadal aromatase activity and steroid hormone levels in female and polymorphic males of the peacock blenny Salaria pavo

Gonçalves

Teles

Alpedrinha

et al. 2008

Hormones and Behavior

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In the peacock blenny Salaria pavo large males with well-developed secondary sexual characters establish nests and attract females while small "sneaker" males mimic female sexual displays in order to approach the nests of larger males and parasitically fertilize eggs. These alternative reproductive tactics are sequential, as sneakers irreversibly switch into nesting males. This transition involves major morphologic and behavioral changes and is likely to be mediated by hormones. This study focuses on the role of aromatase, an enzyme that catalyses the conversion of androgens into estrogens, in the regulation of male sexual polymorphism in S. pavo. For this, sex steroid plasma levels and aromatase activity (AA) in gonads, whole brain and brain macroareas were determined in sneakers, transitional males (i.e. sneakers undergoing the transition into nesting males), nesting males and females collected in the field. AA was much higher in ovarian tissue than in testicular tissue and accordingly circulating estradiol levels were highest in females. This supports the view that elevated AA and estradiol levels are associated with the development of a functional ovary. Transitional males are in a non-reproductive phase and had underdeveloped testes when compared with sneakers and nesting males. Testicular AA was approximately 10 times higher in transitional males when compared with sneakers and nesting males, suggesting high AA has a suppressive effect on testicular development. Nesting males had significantly higher plasma levels of both testosterone (T) and 11-ketotestosterone when compared with the other male morphs and previous studies demonstrated that these androgens suppress female-like displays in sneakers. In the brain, AA was highest in macroareas presumably containing hypothalamic nuclei traditionally associated with the regulation of reproductive behaviors. Overall, females presented the highest levels of brain AA. In male morphs AA increased from sneakers, to transitional males, to nesting males in all brain macroareas. These results suggest that the transition into the nesting male tactic is accompanied both by an increase in testicular androgen production and by a higher conversion of androgens into estrogens in the brain. The increase in androgen production is likely to mediate the development of male secondary sexual characters while the increase in brain AA may be related to the behavioral changes associated with tactic transition.

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Section: Brain Aromatase Activitysupporting

confidence: 74%

Section: Introductionmentioning

confidence: 99%

Brain and gonadal aromatase activity and steroid hormone levels in female and polymorphic males of the peacock blenny Salaria pavo

Gonçalves

Teles

Alpedrinha

et al. 2008

Hormones and Behavior

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show abstract

“…Interestingly, we observed that sildenafil significantly inhibited aromatase activity in a dose-dependent manner, inducing about 38% of decrease at 1 µM of concentration (Table 2). Moreover, on the basis of the relevance of aromatase protein in neural cells, where estrogens have been demonstrated to act as neurotransmitters [48] and to be neuroprotective [49], as additional model of analysis we used the neural progenitor ST14A cell line. Cells were transfected with an aromatase expression vector and protein expression was confirmed by Western blotting analysis ( Figure 6).…”

Section: Effect Of Sildenafil On Full-length Aromatase Activity In Cellsmentioning

confidence: 99%

Effect of sildenafil on human aromatase activity: From in vitro structural analysis to catalysis and inhibition in cells

Baravalle

Valetti

Catucci

et al. 2017

The Journal of Steroid Biochemistry and Molecular Biology

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“…Notably, the male hormone testosterone is readily converted to 17b-estradiol by aromatase in neurons and astrocytes, which suggests that endogenous androgen levels in males may affect 17b-estradiol-mediated protection after SCI (Roselli, 2007). Testosterone in males is physiologically secreted by the testes and adrenal glands, and acts primarily via androgen receptors.…”

mentioning

confidence: 99%

Effect of Endogenous Androgens on 17β-Estradiol-Mediated Protection after Spinal Cord Injury in Male Rats

Kachadroka

Hall

Niedzielko

et al. 2010

Journal of Neurotrauma

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Several groups have recently shown that 17b-estradiol is protective in spinal cord injury (SCI). Testosterone can be aromatized to 17b-estradiol and may increase estrogen-mediated protection. Alternatively, testosterone has been shown to increase excitotoxicity in models of central nervous system (CNS) injury. These experiments test the hypothesis that endogenous testosterone in male rats alters 17b-estradiol-mediated protection by evaluating a delayed administration over a clinically relevant dose range and manipulating testicular-derived testosterone. Adult male Sprague Dawley rats were either gonadectomized or left gonad-intact prior to SCI. SCI was produced by a midthoracic crush injury. At 30 min post SCI, animals received a subcutaneous pellet of 0.0, 0.05, 0.5, or 5.0 mg of 17b-estradiol, released over 21 days. Hindlimb locomotion was analyzed weekly in the open field. Spinal cords were collected and analyzed for cell death, expression of Bcl-family proteins, and white-matter sparing. Post-SCI administration of the 0.5-or 5.0-mg pellet improved hindlimb locomotion, reduced urinary bladder size, increased neuronal survival, reduced apoptosis, improved the Bax=Bcl-xL protein ratio, and increased white-matter sparing. In the absence of endogenous testicular-derived androgens, SCI induced greater apoptosis, yet 17b-estradiol administration reduced apoptosis to the same extent in gonadectomized and gonadintact male rats. These data suggest that delayed post-SCI administration of a clinically relevant dose of 17b-estradiol is protective in male rats, and endogenous androgens do not alter estrogen-mediated protection. These data suggest that 17b-estradiol is an effective therapeutic intervention for reducing secondary damage after SCI in males, which could be readily translated to clinical trials.

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Brain aromatase: Roles in reproduction and neuroprotection

Cited by 109 publications

References 109 publications

Brain and gonadal aromatase activity and steroid hormone levels in female and polymorphic males of the peacock blenny Salaria pavo

Brain and gonadal aromatase activity and steroid hormone levels in female and polymorphic males of the peacock blenny Salaria pavo

Effect of sildenafil on human aromatase activity: From in vitro structural analysis to catalysis and inhibition in cells

Effect of Endogenous Androgens on 17β-Estradiol-Mediated Protection after Spinal Cord Injury in Male Rats

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