2011
DOI: 10.1073/pnas.1014775108
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Brain angiogenesis inhibitor 1 (BAI1) is a pattern recognition receptor that mediates macrophage binding and engulfment of Gram-negative bacteria

Abstract: Bacterial recognition by host cells is essential for initiation of infection and the host response. Bacteria interact with host cells via multiple pattern recognition receptors that recognize microbial products or pathogen-associated molecular patterns. In response to this interaction, host cell signaling cascades are activated that lead to inflammatory responses and/or phagocytic clearance of attached bacteria. Brain angiogenesis inhibitor 1 (BAI1) is a receptor that recognizes apoptotic cells through its con… Show more

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Cited by 131 publications
(176 citation statements)
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“…5g; . BAI1 has also been implicated in bacterial engulfment 23 and indeed there is a decrease in clearance efficiency when we inject fluorescently labelled bacteria in BAI1 morphant brains ( Supplementary Fig. 2g).…”
Section: Temporal Dissection Of Apoptotic Cell Clearance By Microgliamentioning
confidence: 99%
“…5g; . BAI1 has also been implicated in bacterial engulfment 23 and indeed there is a decrease in clearance efficiency when we inject fluorescently labelled bacteria in BAI1 morphant brains ( Supplementary Fig. 2g).…”
Section: Temporal Dissection Of Apoptotic Cell Clearance By Microgliamentioning
confidence: 99%
“…CD55 interacts with the N-terminal epidermal growth factor (EGF)-like domains of CD97 (6)(7)(8), an aGPCR broadly expressed by hematopoietic and nonhematopoietic cells (9)(10)(11). Subsequently identified aGPCR ligands were dermatan sulfate, a5b1 integrin, tissue transglutaminase 2, phosphatidylserine, LPS, C1q, lasso/teneurin-2, collagen III, and Thy-1/CD90 (12)(13)(14)(15)(16)(17)(18)(19)(20). Evidence was obtained that aGPCRs have a role in cell positioning and tissue organization in various organ systems (21,22); however, in the strictest sense, aGPCRs are still functional orphans.…”
mentioning
confidence: 99%
“…Adhesion-GPCRs are thus thought to possess a dual cellular adhesion and signaling function. Recent studies have revealed many important functions for adhesion-GPCRs: these include development of the brain frontal cortex (34), circulation of cerebrospinal fluid (44), central nervous system (CNS)-restricted angiogenesis and vascularization (1, 10, 21), myelination of Schwann cells (30, 31), Usher syndrome (29, 49), cellular polarity (16, 23), epididymal fluid regulation and male fertility (4, 12), and immune recognition and regulation (11,18,27,47), as well as tumor growth and metastasis (8,17,43,50). However, the molecular mechanisms mediating the biological functions of adhesion-GPCRs remain to be fully characterized.…”
mentioning
confidence: 99%