Brain and Vascular Monoamine Oxidase Activity in the Deoxycorticosterone‐salt Hypertensive Rat

Lai, F.M.; Spector, Sydney

doi:10.1111/j.1476-5381.1977.tb08391.x

Cited by 9 publications

(1 citation statement)

References 11 publications

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“…In fact, the preliminary data of Spectoret al (1972) indi cated that the activity of monoamine oxidase (MAO) was elevated in the mesenteric arter ies of spontaneously hypertensive rats (SHR); Berkowit: et al (1973) also observed an in creased MAO activity in the aorta and the mesenteric arteries of deoxycorticosterone (DOCA)-salt hypertensive rats. On the con trary, Tarver et al (1971) did not find any change in MAO activity in the mesenteric arteries of SHR, and Lai and Spector (1977) observed no changes in MAO activity in the aorta and the mesenteric arteries of SHR and DOCA-salt hypertensive rats. Catechol-Omethyltransferase (COMT) activity was in creased in the aorta and the mesenteric arter ies of SHR and DOCA-salt hypertensive rats (Tratjkovet al" 1974).…”

Section: Introductionmentioning

confidence: 92%

Uptake and Metabolism of Noradrenaline by Blood Vessels of Perinephritic Hypertensive Dogs

Garrett¹,

Castro-Tavares²,

Branco³

1981

J Vasc Res

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Tissue noradrenaline content as well as uptake and metabolism of tritiated exogenous noradrenaline were studied comparatively, in vitro in mesenteric arteries, and in saphenous veins of normotensive and perinephritic hypertensive dogs. The influence of cocaine, iproniazid and 3’-4’-dihydroxy-2-methyµ-propiophenone (U-0521) on these variables wasalso investigated. The concentration of (–)-7-³H-noradrenaline used was 1.084 µM. No changes were observed in noradrenaline content, uptake and metabolism in saphenous vein strips obtained from normotensive or hypertensive animals. However, in mesenteric artery strips obtained from hypertensive dogs, a marked reduction in endogenous noradrenaline content was observed as well as a reduction in noradrenaline accumulation (20 weeks after surgery). The deamination pattern was also modified in these strips: the formation of DOPEGwas markedly diminished and the formation of DOMA was increased. These results agree well with the degeneration of the sympathetic innervation of the mesenteric arteries of hypertensive dogs described by Azevedo et al. (1981).

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Section: Introductionmentioning

confidence: 92%

Uptake and Metabolism of Noradrenaline by Blood Vessels of Perinephritic Hypertensive Dogs

Garrett¹,

Castro-Tavares²,

Branco³

1981

J Vasc Res

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Monoamine oxidase activity in tissues of spontaneously hypertensive rats

Lai

Spector

1978

Experientia

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Monoamine oxidase (MAO) activity was assayed both in central and peripheral blood vessels of spontaneously hypertensive rats (SHR) and age-matched normotensive Wistar Kyoto rats (WKR). The activity of MAO in the brain and peripheral vasculature was essentially the same in both SHR and WKR. It can therefore be concluded that central and peripheral vascular MAO activity is not altered in the genetically hypertensive animals.

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