Brain and muscle oxygenation monitoring using near-infrared spectroscopy (NIRS) during all-night sleep

Zhang, Zhongxing; Khatami, Ramin

doi:10.1117/12.1000152

Cited by 4 publications

(4 citation statements)

References 37 publications

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“…Deoxygenated hemoglobin levels display a reverse trend resulting in no net change in total hemoglobin levels. According to a study that measured hemoglobin levels both in muscle and cortex during sleep, HbO level decreases and HbR level increases during onset of sleep but this trend is reversed during transition to deep sleep (SWS) (Zhang and Khatami, 2013). As the researchers observed this transition both in brain and muscle tissue, they concluded that it is a systemic physiological response rather than having cortical specificity.…”

Section: Discussionmentioning

confidence: 99%

Sleep Is a Refreshing Process: An fNIRS Study

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et al. 2019

Front. Hum. Neurosci.

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Sleep is a very critical process that constitutes up to one third of daytime of a healthy adult. It is known to be an active period where body and brain is refreshed for the next day. It is both part of a larger cycle, i.e., circadian rhythm, and has subcsycles in it, i.e., sleep stages. Although hemodynamics of these stages have been investigated especially in the last two decades, there are still points in the hemodynamics to be illuminated especially in terms of refreshment. This study aims to investigate refreshing property of sleep in terms of sleep stages using functional near-infrared spectroscopy (fNIRS) for measuring prefrontal cortex (PFC) hemodynamics. Nine healthy subjects slept in sleep laboratories, monitored by polysomnography and fNIRS before, during, and after night sleep. REM stage had lower oxyhemoglobin (HbO) and total hemoglobin (HbT) than the other sleep stages and wakefulness. Deoxyhemoglobin (HbR) did not differ between any stages. All sleep stages and wakefulness stage at the end of the sleep had higher HbO and lower HbR than the beginning of the sleep. HbT levels did not differ between the beginning and the end of the sleep for any stages. During REM sleep, PFC seems to get lower blood supply, possibly due to increased demand in other brain regions. Regardless of the stage, PFC has higher oxygenation toward the end of sleep, indicating refreshment. Overall, our brain seems to be on duty during sleep throughout the night for “cleaning” and “refreshing” itself. Hemodynamic changes from the beginning to end of sleep might be the indicator of this work. Thus, accordingly REM stage seems to be at a central point for this work.

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Section: Discussionmentioning

confidence: 99%

Sleep Is a Refreshing Process: An fNIRS Study

Öniz

İnanç

Taşlıca

et al. 2019

Front. Hum. Neurosci.

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“…Several well-established neuroimaging methodologies including computed tomography (CT), functional magnetic resonance imaging (fMRI), positron emission tomography (PET), single-photon emission computed tomography (SPECT), transcranial Doppler (TCD), and near-infrared spectroscopy (NIRS) have been widely used to study cerebral autoregulation mechanism under various physiological and pathological states in both healthy subjects and patients. [12][13][14][15][16][17][18][19] Several attempts to determine cerebral hemodynamics in OSA using these techniques faced some limitations. CT, fMRI, PET and SPECT are only suitable to study the cerebral hemodynamics in OSA patients during wakefulness, [20][21][22] but not during all night sleep due to obvious reasons including safety issues, radiation, high magnetic¯elds, loud noises, motion artifacts, compatibility of CPAP device, etc.…”

Section: Introductionmentioning

confidence: 99%

Near-infrared spectroscopy (NIRS) as a useful tool to evaluate the treatment efficacy of positive airways pressure therapy in patients with obstructive sleep apnea syndrome (OSAS): A pilot study

Zhang

Schneider

Fritschi

et al. 2014

J. Innov. Opt. Health Sci.

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In obstructive sleep apnea syndrome (OSA) the periodic reduction or cessation of breathing due to narrowing or occlusion of the upper airway during sleep leads to an impaired cerebral vascular autoregulation that is associated with an increased cardiovascular risk, including stroke. Continuous positive airways pressure (CPAP) therapy at night is the most e®ective treatment for OSA and has been shown to reduce the cardiovascular risk in OSA patients. However, there is no suitable bedside monitoring method evaluating the recovery of cerebral hemodynamics during CPAP therapy. Near-infrared spectroscopy (NIRS) is ideally suited for non-invasive monitoring the cerebral hemodynamics during sleep due to its properties of local measurement, totally safe application and good tolerance to motion. In this pilot study, we monitored cerebral hemodynamics during standard CPAP therapy at night in three patients with severe OSA using NIRS. We found periodic oscillations in HbO 2 , HHb, tissue oxygenation index (TOI) and blood volume (BV) associated with periodic apnea events without CPAP in all OSA patients. These oscillations were eliminated under the optimal CPAP pressures in all patients. These results suggested that the recovery of cerebral hemodynamics impaired by apnea events can be evaluated by bedside NIRS measurements in real time during all night CPAP therapy. NIRS is a useful bedside monitoring tool to evaluate the treatment e±cacy of CPAP therapy in patients with OSA.

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“…Compared to these techniques, as a totally non-invasive and non-radiation optical method NIRS can robustly measure oxygenated (HbO2) and deoxygenated (HHb) hemoglobin (Hb), blood flow (BF), blood volume (BV) and tissue oxygen saturation index (TOI) changes in local cerebral regions [10][11] . It is a powerful tool to study cerebral hemodynamics during all night sleep 12 . Several studies with NIRS repeatedly reported an impairment of cerebral oxygenation in the patients with sleep apnea [13][14][15][16][17][18] .…”

Section: Introductionmentioning

confidence: 99%

A pilot study to compare the cerebral hemodynamics between patients with obstructive sleep apnea syndrome (OSA) and periodic limb movement syndrome (PLMS) during nocturnal sleep with near-infrared spectroscopy (NIRS)

et al. 2014

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Obstructive sleep apnea syndrome (OSA) and periodic limb movement in sleep syndrome (PLMS) are two common sleep disorders. Previous studies showed that OSA and PLMS share common features, such as increased cardio-vascular risk, both apnea events and limb movements occur periodically, they are usually associated with cortical arousals, and both of them can induce declines in peripheral oxygen saturation measured with pulse oximetry. However, the question whether apnea events and limb movements also show similar characteristics in cerebral hemodynamic and oxygenation has never been addressed. In this pilot study, we will first time compare the cerebral hemodynamic changes induced by apnea events and limb movements in patients with OSA (n=4) and PLMS (n=4) with NIRS. In patients with OSA, we found periodic oscillations in HbO2, HHb, and blood volume induced by apnea/hypopnea events, HbO2 and HHb showed reverse changing trends. By contrast, the periodic oscillations linked to limb movements were only found in HbO2 and blood volume in patients with PLMS. These findings of different cerebral hemodynamics patterns between apnea events and limb movements may indicate different regulations of nervous system between these two sleep disorders.

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Brain and muscle oxygenation monitoring using near-infrared spectroscopy (NIRS) during all-night sleep

Cited by 4 publications

References 37 publications

Sleep Is a Refreshing Process: An fNIRS Study

Sleep Is a Refreshing Process: An fNIRS Study

Near-infrared spectroscopy (NIRS) as a useful tool to evaluate the treatment efficacy of positive airways pressure therapy in patients with obstructive sleep apnea syndrome (OSAS): A pilot study

A pilot study to compare the cerebral hemodynamics between patients with obstructive sleep apnea syndrome (OSA) and periodic limb movement syndrome (PLMS) during nocturnal sleep with near-infrared spectroscopy (NIRS)

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