Brain and muscle of Wistar rats are the main targets of intravenous dendrimeric sulfadiazine

Prieto, María Jimena; Schilrreff, Priscila; Tesoriero, María Victoria Defain; Morilla, María José; Romero, Eder Lilia

doi:10.1016/j.ijpharm.2008.04.045

Cited by 19 publications

(17 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, the complexed drug would acquire the physicochemical properties of the dendrimers, which would significantly increase its solubility in aqueous media and, therefore, modify its pharmacokinetics and biodistribution properties. In previous works, our group demonstrated that the drugs sulfadiazine and risperidone complexed with PAMAM dendrimers increment their solubility in water and the arrival to the brain, generating an increase in the potency of their effect (M. Prieto et al, 2006;M. Prieto et al, 2008;Maria Jimena Prieto et al, 2013;Maria Jimena Prieto et al, 2014;María Jimena Prieto et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

PAMAM dendrimers as a carbamazepine delivery system for neurodegenerative diseases: A biophysical and nanotoxicological characterization

Igartúa

Martínez

Temprana

et al. 2018

International Journal of Pharmaceutics

View full text Add to dashboard Cite

Carbamazepine (CBZ) is an antiepileptic drug, which also could be used in the treatment of neurodegenerative diseases, such as the Alzheimer's disease. However, its use has been limited due to its low solubility, inefficient pharmacokinetic profiles, and multiple side effects. PAMAM dendrimers, ethylenediamine core, generation 4.0 (amine terminal groups) and 4.5 (carboxylate terminal groups) (DG4.0 and DG4.5 respectively) are polymers that can increase drug solubility through complexation. Thus, the aim of this work was to obtain and characterize complexes between CBZ and dendrimers. Both DG4.0 and DG4.5 allowed the incorporation of ∼20 molecules of CBZ per dendrimer, into their hydrophobic pockets. DG4.0-CBZ and DG4.5-CBZ complexes were found to be stable for 90 days at 37 °C and resistant to a lyophilization process, presenting controlled drug release. Also, the complexes nanotoxicity was tested ex vivo (human red blood cells), in vitro (N2a cell line), and in vivo (zebrafish). No hemolytic effect was observed in the ex vivo model. As regards in vitro toxicity, the DG4.5-CBZ complexes significantly reduced the toxicity caused by the free drug. Moreover, the DG4.5-CBZ did not cause neurotoxicity or cardiotoxicity in zebrafish larvae. In conclusion, a stable and biocompatible drug delivery system based on the DG4.5 capable of complex the CBZ has been developed. This achievement highlights the advantages of using negatively charged dendrimers for nanomedicine.

show abstract

Section: Introductionmentioning

confidence: 99%

PAMAM dendrimers as a carbamazepine delivery system for neurodegenerative diseases: A biophysical and nanotoxicological characterization

Igartúa

Martínez

Temprana

et al. 2018

International Journal of Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…In the last years, several strategies to overcome these issues, particularly the design of nano‐ and microstructured drug carrier systems, have been proposed . However, these kinds of carriers (plain, ultradeformable, stealth or pH‐sensitive liposomes, immunoliposomes, nanoparticles, dendrimers, and emulsions) must be carefully designed and/or chosen because their pharmacokinetics, biodistribution, and tissue selectivity will exclusively depend on the carrier's structure …”

Section: Introductionmentioning

confidence: 99%

Development of Nutraceutical Emulsions as Risperidone Delivery Systems: Characterization and Toxicological Studies

Igartúa

Calienni

Feas

et al. 2015

Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

“…Prieto et al [219] investigated the cytotoxicity of sulfadiazine complexed with fourth-generation PAMAM dendrimers. Cell culture studies using fibroblasts (Vero cells) and macrophages (J-774 cells) revealed that the dendrimeric sulfadiazine complexes did not affect membrane integrity at low concentrations (0.03 M).…”

Section: Drug Delivery Applications Of Dendrimers and Dendronized Polmentioning

confidence: 99%

Dendrimers and derivatives as a potential therapeutic tool in regenerative medicine strategies—A review

Oliveira

Salgado

Sousa

et al. 2010

Progress in Polymer Science

175

View full text Add to dashboard Cite

a b s t r a c tSince the pioneering work dealing with the synthesis and physicochemical aspects of dendrimers, a predictable and tunable set of compositions for therapeutic, scaffolding and imaging systems has been reported. These are well documented, but many hot issues should be examined and reviewed. Herein, a review is given on dendritic nanopolymers and their applications that show promise in the field of regenerative medicine. This review begins with a brief overview on research merging nanotechnology and regenerative medicine. Fundamentals of the synthesis and macromolecular structure of dendritic polymers are provided. Dendrimers fulfill the requirements as carriers for gene, nucleic acids, bioactive molecules and peptide/protein delivery aimed at modulate the cells functions, in vitro and in vivo. However, to make use of this potential, toxicological, drug-loading capacity, surface engineering and host-guest chemistries in dendrimers must be addressed and thus are also discussed. We focus on recent work involving dendrimers with applications in tissue engineering and the central nervous system. Due to their innovative character, applications beyond drug delivery systems became possible, namely as scaffolding and chemoattractants for tissue regeneration, and implantable biodegradable nanomaterialbased medical devices integrated with drug delivery functions (theranostics). Finally, we highlight promising areas for further research and comment on how and why dendrimer and dendron technology should be viewed as the next generation of biomaterials for the 21st century.

show abstract

Brain and muscle of Wistar rats are the main targets of intravenous dendrimeric sulfadiazine

Cited by 19 publications

References 39 publications

PAMAM dendrimers as a carbamazepine delivery system for neurodegenerative diseases: A biophysical and nanotoxicological characterization

PAMAM dendrimers as a carbamazepine delivery system for neurodegenerative diseases: A biophysical and nanotoxicological characterization

Development of Nutraceutical Emulsions as Risperidone Delivery Systems: Characterization and Toxicological Studies

Dendrimers and derivatives as a potential therapeutic tool in regenerative medicine strategies—A review

Contact Info

Product

Resources

About