Brain and muscle adaptation to high-fat diets and exercise: Metabolic transporters, enzymes and substrates in the rat cortex and muscle

Béland-Millar, Alexandria; Takimoto, Masaki; Hamada, Taku; Messier, Claude

doi:10.1016/j.brainres.2020.147126

Cited by 3 publications

(1 citation statement)

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“…For both MCT1 and MCT2, no selectivity for AcAc versus βOHB has been observed (61). While dynamic expression of MCTs in varying physiological states has been posed to regulate ketone body turnover, mechanisms that dynamically regulate MCT abundance have not yet been proven to be either necessary or sufficient to augment ketone efflux or import (8). One study showed the requirement for MCT2 expression for the permissive role of βOHB in driving breast cancer tumorigenesis (74), but the relationship between MCT2 expression and tumorigenesis in breast cancer has not been observed uniformly (105).…”

Section: Cellular Transport Of Ketonesmentioning

confidence: 99%

Metabolic and Signaling Roles of Ketone Bodies in Health and Disease

2021

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Ketone bodies play significant roles in organismal energy homeostasis, serving as oxidative fuels, modulators of redox potential, lipogenic precursors, and signals, primarily during states of low carbohydrate availability. Efforts to enhance wellness and ameliorate disease via nutritional, chronobiological, and pharmacological interventions have markedly intensified interest in ketone body metabolism. The two ketone body redox partners, acetoacetate and D-β-hydroxybutyrate, serve distinct metabolic and signaling roles in biological systems. We discuss the pleiotropic roles played by both of these ketones in health and disease. While enthusiasm is warranted, prudent procession through therapeutic applications of ketogenic and ketone therapies is also advised, as a range of metabolic and signaling consequences continue to emerge. Organ-specific and cell-type-specific effects of ketone bodies are important to consider as prospective therapeutic and wellness applications increase.

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