Brain and Body

Olbrich, Sebastian; Sander, Christian; Matschinger, Herbert; Mergl, Roland; Trenner, M; Schönknecht, Peter; Hegerl, Ulrich

doi:10.1027/0269-8803/a000061

Cited by 51 publications

(23 citation statements)

References 57 publications

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“…This finding is in line with the study findings from Olbrich et al [11] and more recently by Jawinski et al [28], who demonstrated a gradual change of ANS activity in different states of brain arousal in 15-min resting EEG data. Most importantly, these gradual ANS changes were present in most cases within each 30-min time block.…”

Section: Discussionsupporting

confidence: 93%

“…Earlier versions of VIGALL have been validated using EEG-fMRI data [10], in a PET study [23], against evoked potentials [24] and relating ANS parameters to different EEG-vigilance stages [11]. …”

Section: Introductionmentioning

confidence: 99%

“…Olbrich et al [11] compared HR and SCL of healthy individuals in different EEG-vigilance stages using an earlier version of VIGALL to 15-min resting EEG data. High EEG-vigilance stages showed significantly higher HR and SCL activity in comparison to lower EEG-vigilance stages in regression analyses, but this was not the case for the comparisons between stage 0 and A1 (possibly due to the misclassification of stage 0, according to the authors).…”

Section: Introductionmentioning

confidence: 99%

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Impact of brain arousal and time-on-task on autonomic nervous system activity in the wake-sleep transition

et al. 2018

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BackgroundAutonomic nervous system (ANS) activity has been shown to vary with the state of brain arousal. In a previous study, this association of ANS activity with distinct states of brain arousal was demonstrated using 15-min EEG data, but without directly controlling for possible time-on-task effects. In the current study we examine ANS-activity in fine-graded EEG-vigilance stages (indicating states of brain arousal) during two conditions of a 2-h oddball task while controlling for time-on-task. In addition, we analyze the effect of time-on-task on ANS-activity while holding the level of brain arousal constant.MethodsHeart rate and skin conductance level of healthy participants were recorded during a 2-h EEG with eyes closed under simultaneous presentation of stimuli in an ignored (N = 39) and attended (N = 39) oddball condition. EEG-vigilance stages were classified using the Vigilance Algorithm Leipzig (VIGALL 2.1). The time-on-task effect was tested by dividing the EEG into four 30-min consecutive time blocks. ANS-activity was compared between EEG-vigilance stages across the entire 2 h and within each time block.ResultsWe found a coherent decline of ANS-activity with declining brain arousal states, over the 2-h recording and in most cases within each 30-min block in both conditions. Furthermore, we found a significant time-on-task effect on heart rate, even when arousal was kept constant. It was most pronounced between the first and all subsequent blocks and could have been a consequence of postural change at the beginning of the experiment.ConclusionOur findings contribute to the validation of VIGALL 2.1 using ANS parameters in 2-h EEG recording under oddball conditions.Electronic supplementary materialThe online version of this article (10.1186/s12868-018-0419-y) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Impact of brain arousal and time-on-task on autonomic nervous system activity in the wake-sleep transition

et al. 2018

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“…The effect on the psychiatric symptoms therefore might be less attributable to the psychopharmacological impact on central active neurotransmitters, but on the normalization of sleep rhythms and consecutive change at the behavioural level as suggested by the "vigilance framework" [2]. Interestingly, within the presented case, not only CNS but also ANS parameters showed levels of higher arousal, which might be interpreted in line with the close association between ANS and CNS arousal markers [5,7,25]. Further, quetiapine has been shown to reduce HRV measures and thereby probably increase sympathetic tone in a psychiatric cohort [26].…”

Section: Discussionsupporting

confidence: 67%

Efficacy of Low Adjunctive Quetiapine Administration in Control of Hypomanic State in Bipolar Affective Disorder Captured by EEG

Adamaszek¹,

Olbrich²

2017

J Neuroimaging Psychiatry Neurol

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Aim: According to current biopsychiatric models, hypomania is associated with subvigil patterns in EEG, suggesting a significant impact of instable vigilance dynamics to bipolar disorders. Quetiapine as a well-accepted treatment option in bipolar disorders has been suggested to modify vigilance regulation by its high affinity to 5HT1A receptors at raphe nucleus, so even a low dose administration of quetiapine might be quite efficient to guide the recovery of the presumed instable vigilance dynamic in hypomanic state of bipolar disorder. Methods:We report a patient with a bipolar disorder, who experienced a hypomanic state under an established drug treatment with valproic acid and olanzapine. For evaluation of therapeutic response to low dose quetiapine, structured clinical interview and discrete EEG analysis of initial and follow up recordings were administered.Results: Administration of a low dose of 50 mg quetiapine per night as an adjunctive treatment to prescribed psychopharmacologic drug formulation was followed not only by the intended improvement of sleep comfort, but also by a complete control of hypomanic state. Clinical improvement was accompanied with a restoring of initially EEG recorded patterns of impaired vigilance regulation. Conclusion:Our report emphasizes the advantage of stratifying presumed effectiveness of quetiapine already at low dose administration in controlling exacerbated bipolar disorders by combined clinical and neurophysiological approaches as suggested by EEG, in particular due to specific stabilizing mechanisms at the cerebral vigilance regulation system.

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“…By measuring the topographic distribution and spectral composition of electroencephalic activity as well as the presence of slow eye movements, VIGALL enables the objective classification of so-called stages of vigilance (brain arousal), ranging from focused wakefulness via relaxed wakefulness and drowsiness to sleep onset [31,32]. It has been validated in a simultaneous EEG/fMRI study [33], in a PET study [34] and with parameters of the autonomous nervous system [35]. …”

Section: Introductionmentioning

confidence: 99%

Brain Arousal Regulation in Carriers of Bipolar Disorder Risk Alleles

Jawinski¹,

Sander²,

Mauche³

et al. 2015

Neuropsychobiology

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Objectives: Recent genome-wide association studies identified a number of chromosomal risk loci for bipolar disorder (BD, ‘manic-depressive illness'). According to the vigilance regulation model, the regulation of brain arousal (referred to as ‘vigilance') when assessed via EEG is an emerging biomarker linked to the pathogenesis of manic and depressive episodes. On this basis, the present study aimed to assess whether carriers of BD risk alleles differ in brain arousal regulation. Methods: Healthy participants of the population-based Leipzig Health Care Study (LIFE) underwent a 20-min eyes-closed resting EEG paradigm. Brain arousal was assessed applying the computer-based Vigilance Algorithm Leipzig (VIGALL). The primary sample (n = 540) was genotyped for ten of the most reliable BD risk variants, of which two qualified for replication (n = 509). Results: Primary sample analyses revealed Bonferroni-adjusted significance for rs1006737 in CACNA1C (encoding a calcium channel subunit), with risk allele carriers exhibiting relatively steep brain arousal declines. Further, carriers of two risk alleles of rs472913 at 1p32.1 showed generally lower brain arousal levels for the duration of the resting paradigm. However, both associations failed replication. Conclusion: Although our initial findings are in line with the vigilance regulation model and convincing in view of the previously reported notable role of ion channelopathies in BD, our results do not provide consistent evidence for a link between BD risk variants and brain arousal regulation. Several between-sample differences may account for this inconsistency. The molecular genetics of brain arousal regulation remain to be clarified.

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Brain and Body

Cited by 51 publications

References 57 publications

Impact of brain arousal and time-on-task on autonomic nervous system activity in the wake-sleep transition

Impact of brain arousal and time-on-task on autonomic nervous system activity in the wake-sleep transition

Efficacy of Low Adjunctive Quetiapine Administration in Control of Hypomanic State in Bipolar Affective Disorder Captured by EEG

Brain Arousal Regulation in Carriers of Bipolar Disorder Risk Alleles

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