Brain Aging and Performance Plasticity in Honeybees

Münch, Daniel; Amdam, Gro V.

doi:10.1016/b978-0-12-415823-8.00037-x

Cited by 5 publications

(6 citation statements)

References 137 publications

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“…For both enzymes we found that relative GS and GP abundance levels were reduced in the old as compared to the mature control (MWU for GS: df = 1, N mat/old = 12/13, Z = -2.02, P<0.05, Fig 4A ; MWU for GP: df = 1, N mat/old = 11/14, Z = -2.03, P<0.05, Fig 4B ). This effect was only present, when both foraging duration and morphological criteria of senescence were stipulated to minimize heterogeneity that is typical for the old group (data not shown, [ 31 , 33 ]). We did not observe replicate effects between the different colonies for GS (MWU for GS: df = 1, N C1/C2 = 13/12, Z = 0.68, P = 0.4956).…”

Section: Resultsmentioning

confidence: 98%

“…Among the behavioral decline patterns in old forager bees, are reduced olfactory and tactile learning as well as changed spatial extinction in home finding tests [ 31 ]. In particular, the reduction of GS levels may cause senescence by affecting glutamatergic transmission.…”

Section: Discussionmentioning

confidence: 99%

“…As one of the principal models in invertebrate brain research, the honey bee features a complex social behavior, a well-studied neuroanatomy, and relatively simple test paradigms to study learning and memory are established [ 2 ]. Adapting such learning protocols [ 28 ], research in the last decade has revealed that extreme lifespan and aging differences depend on worker type (‘sub-castes’, [ 29 ]), rather than on chronological age [ 30 , 31 ]. For example, short-lived foragers can develop typical aging symptoms within a few days only, while winter bees can exhibit negligible aging for many months [ 28 , 32 – 37 ].…”

Section: Introductionmentioning

confidence: 99%

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Metabolic enzymes in glial cells of the honeybee brain and their associations with aging, starvation and food response

et al. 2018

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The honey bee has been extensively studied as a model for neuronal circuit and memory function and more recently has emerged as an unconventional model in biogerontology. Yet, the detailed knowledge of neuronal processing in the honey bee brain contrasts with the very sparse information available on glial cells. In other systems glial cells are involved in nutritional homeostasis, detoxification, and aging. These glial functions have been linked to metabolic enzymes, such as glutamine synthetase and glycogen phosphorylase. As a step in identifying functional roles and potential differences among honey bee glial types, we examined the spatial distribution of these enzymes and asked if enzyme abundance is associated with aging and other processes essential for survival. Using immunohistochemistry and confocal laser microscopy we demonstrate that glutamine synthetase and glycogen phosphorylase are abundant in glia but appear to co-localize with different glial sub-types. The overall spatial distribution of both enzymes was not homogenous and differed markedly between different neuropiles and also within each neuropil. Using semi-quantitative Western blotting we found that rapid aging, typically observed in shortest-lived worker bees (foragers), was associated with declining enzyme levels. Further, we found enzyme abundance changes after severe starvation stress, and that glutamine synthetase is associated with food response. Together, our data indicate that aging and nutritional physiology in bees are linked to glial specific metabolic enzymes. Enzyme specific localization patterns suggest a functional differentiation among identified glial types.

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Section: Resultsmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Metabolic enzymes in glial cells of the honeybee brain and their associations with aging, starvation and food response

et al. 2018

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“…It should be pointed out that studies on the ability to remember an association some time after the learning experience, or on the ability to discriminate between a learned stimulus and a related one, found little or no effect of age (Scheiner & Amdam, 2009;Behrends & Scheiner, 2010), or even that older foragers are better at discrimination (Behrends et al, 2007). Senescence in worker honeybees is therefore a heterogeneous process, with different functions showing different patterns of decline (summarised by Münch, 2013).…”

Section: Senescence In Workersmentioning

confidence: 99%

Explaining Extraordinary Life Spans

Lucas¹,

Keller²

2017

The Evolution of Senescence in the Tree of Life

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The striking differences in lifespan observed among some social insect castes offer unique opportunities to study ageing and have therefore attracted increasing attention. While evolutionary theories of ageing can explain the long lifespan of social insect queens, experimental evidence to support them is lacking or contradictory. Furthermore, how social insects age is still poorly understood. Senescence patterns vary between behavioural worker castes and senescence in honeybee workers can even be reversed by inducing a caste transition, but explicit comparisons between queens and workers are needed to understand how queen longevity is linked to senescence. The ability of queens in advanced insect societies to combine long lifespans with high investment into reproduction presents a physiological puzzle, which may be solved in honeybees by the unique relationship between Juvenile Hormone and Vitellogenin. How this is achieved in other species remains unclear. We finish with a consideration of the challenges facing research into social insect ageing and discuss how these can best be met.

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“…Successively, they shift to outside tasks, mostly foraging for nectar and pollen (forager bees). Forager bees rapidly develop aging symptoms, including increased mortality, impaired behavioral performance, accumulation of lipofuscin (cellular "waste"), oxidative stress damage, and reduced numbers of functional hemocytes (circulating immune cells) (reviewed by Münch and Amdam (2013))). A decline in abundance of intact, circulating immune cells in forager bees could imply that honey bee immunity is a function of behavioral caste (Amdam et al 2005).…”

Section: Introductionmentioning

confidence: 99%

Different activation of immune-related genes in honey bee nurses and foragers (Apis mellifera)

et al. 2019

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Honey bee workers show very flexible aging patterns. Their typical behavioral progression, from nurse bees to forager bees, is associated with an onset of aging symptoms. Here, we studied how immune-activation can affect nurse and forager bees differently. Nurse and forager bees of identical chronological age were injected with vehicle control or the bacterial cell wall components lipopolysaccharide (LPS) or peptidoglycan (PGN). Next, we monitored survival and tested the expression of three immune-related genes. We confirm that forager bees die sooner than same-aged nurse bees, independent of the type of immune challenge. The relative gene expression patterns of two immune-related genes differed between the nurse and forager honey bees as well as between the treatment groups. Our findings support that nurse and forager honey bees can respond differently to immune challenge, despite a lack of detectable differences in mortality between treatments. This response was specifically associated with the workers' behavioral caste, as the chronological age was similar among all tested animals. honeybee / aging / immune activation / vitellogenin / defensin-2

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Brain Aging and Performance Plasticity in Honeybees

Cited by 5 publications

References 137 publications

Metabolic enzymes in glial cells of the honeybee brain and their associations with aging, starvation and food response

Metabolic enzymes in glial cells of the honeybee brain and their associations with aging, starvation and food response

Explaining Extraordinary Life Spans

Different activation of immune-related genes in honey bee nurses and foragers (Apis mellifera)

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