Brain activity is similar during precision and power gripping with light force: An fMRI study

Kuhtz-Buschbeck, Johann P.; Gilster, R.; Wolff, Stephan; Ulmer, Stephan; Siebner, Hartwig R.; Jansen, Olav

doi:10.1016/j.neuroimage.2008.01.037

Cited by 83 publications

(108 citation statements)

References 59 publications

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“…One of the interesting findings of this study is the bilateral activation in lobule VI seen in the main effect of movement analysis; this is in line with previous GF studies [Halder et al, 2007; Kuhtz‐Buschbeck et al, 2008], although it has rarely been discussed or possibly not detected [Keisker et al, 2009]. Our data, however, not only shows a contralateral activation of lobule VI (as well as the more familiar ipsilateral one) but also shows that the activation pattern of lobule VI is not homogenous.…”

Section: Discussionsupporting

confidence: 92%

“…This contrasts with previous analyses at the whole brain level [Alahmadi et al, 2015, 2016d; Ehrsson et al, 2000; Halder et al, 2007; Keisker et al, 2009, 2010; King et al, 2014; Kuhtz‐Buschbeck et al, 2001, 2008; Neely et al, 2013; Noble et al, 2013; Spraker et al, 2012; Vaillancourt et al, 2003; Ward and Frackowiak, 2003]. Some of these studies report a linear association between GF strength and areas of the anterior cerebellum [Halder et al, 2007; Kuhtz‐Buschbeck et al, 2008] but not in the posterior cerebellum, despite the role of the posterior cerebellum in visual processing (when using visual cues) and motor planning [King et al, 2014; Stoodley and Schmahmann, 2010; Stoodley et al, 2012]. Conversely, a recent dynamic power grip study found that the signal in the anterior cerebellum was linearly correlated with forces, whereas the posterior cerebellum evidenced higher signals at low and high forces but low signals at intermediate force levels [Keisker et al, 2009].…”

Section: Introductioncontrasting

confidence: 69%

“…The involvement of lobules VII and IX as well as the contralateral lobule VI can be related to the use of the squeeze ball device, which could represent sensory elements from the fingers and palm. Our paradigm also involves executing a complex dynamic power grip task, requiring cognitive processing, including visuomotor integration [Kuhtz‐Buschbeck et al, 2008], that could modulate cerebellar activity. It is also possible that the widespread activations of the posterior cerebellum are due to the wide range of force levels used in our experimental paradigm; in fact, in a recent power grip study using a very low range of target forces (1–10% MVC), the authors did not detect activations in lobules VII and IX of the cerebellum [Kuhtz‐Buschbeck et al, 2008] while posterior cerebellum activations were noted in other GF studies investigating larger force ranges.…”

Section: Discussionmentioning

confidence: 99%

“…Many neuroimaging studies test for linear relationships between signals that reflect activity at the neuronal level and experimental factors (e.g., forces) [Ashe, 1997; Dettmers et al, 1996; Ehrsson et al, 2001; Halder et al, 2007; Kuhtz‐Buschbeck et al, 2001, 2008; van Duinen et al, 2007], while the nature and meaning of non‐linear relationships—of the sort characterized by psychometric functions in psychophysics—have received less attention. Several reasons may explain this, including difficulties in interpretation and also, importantly, detecting them.…”

Section: Introductionmentioning

confidence: 99%

“…Different explanations may underlie the heterogeneity of published results on this topic, including differences in the types of grip task (power vs. precision), in grip patterns (static vs. dynamic) and importantly, the number and ranges of force levels used in the experimental setting [Alahmadi et al, 2016d; Keisker et al, 2010; King et al, 2014; Kuhtz‐Buschbeck et al, 2008]. …”

Section: Introductionmentioning

confidence: 99%

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Cerebellar lobules and dentate nuclei mirror cortical force‐related‐BOLD responses: Beyond all (linear) expectations

Alahmadi

Pardini

Samson

et al. 2017

Human Brain Mapping

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The relationship between the BOLD response and an applied force was quantified in the cerebellum using a power grip task. To investigate whether the cerebellum responds in an on/off way to motor demands or contributes to motor responses in a parametric fashion, similarly to the cortex, five grip force levels were investigated under visual feedback. Functional MRI data were acquired in 13 healthy volunteers and their responses were analyzed using a cerebellum‐optimized pipeline. This allowed us to evaluate, within the cerebellum, voxelwise linear and non‐linear associations between cerebellar activations and forces. We showed extensive non‐linear activations (with a parametric design), covering the anterior and posterior lobes of the cerebellum with a BOLD‐force relationship that is region‐dependent. Linear responses were mainly located in the anterior lobe, similarly to the cortex, where linear responses are localized in M1. Complex responses were localized in the posterior lobe, reflecting its key role in attention and executive processing, required during visually guided movement. Given the highly organized responses in the cerebellar cortex, a key question is whether deep cerebellar nuclei show similar parametric effects. We found positive correlations with force in the ipsilateral dentate nucleus and negative correlations on the contralateral side, suggesting a somatotopic organization of the dentate nucleus in line with cerebellar and cortical areas. Our results confirm that there is cerebellar organization involving all grey matter structures that reflect functional segregation in the cortex, where cerebellar lobules and dentate nuclei contribute to complex motor tasks with different BOLD response profiles in relation to the forces. Hum Brain Mapp 38:2566–2579, 2017. © 2017 Wiley Periodicals, Inc.

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Section: Discussionsupporting

confidence: 92%

Section: Introductioncontrasting

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cerebellar lobules and dentate nuclei mirror cortical force‐related‐BOLD responses: Beyond all (linear) expectations

Alahmadi

Pardini

Samson

et al. 2017

Human Brain Mapping

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Terahertz time‐domain spectroscopy of poly‐L‐lysine

et al. 2010

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Poly-L-lysine is known to have three different secondary structures depending on solvent conditions because of its flexible nature. In previous work (Kambara et al., Phys Chem Chem Phys 2008, 10, 5042-5044), we observed two different types of structural changes in poly-L-lysine. In the present study, we investigated the low-frequency spectrum of poly-L-lysine with a beta-sheet structure in the solid state by terahertz time-domain spectroscopy. On the basis of this spectroscopic analysis, we found that the low-frequency dynamics differed from those of other polypeptides. Furthermore, we performed powder X-ray diffraction measurement on poly-L-lysine, which was found to be highly amorphous compared with other polypeptides.

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Probing the reaching–grasping network in humans through multivoxel pattern decoding

et al. 2015

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IntroductionThe quest for a putative human homolog of the reaching–grasping network identified in monkeys has been the focus of many neuropsychological and neuroimaging studies in recent years. These studies have shown that the network underlying reaching‐only and reach‐to‐grasp movements includes the superior parieto‐occipital cortex (SPOC), the anterior part of the human intraparietal sulcus (hAIP), the ventral and the dorsal portion of the premotor cortex, and the primary motor cortex (M1). Recent evidence for a wider frontoparietal network coding for different aspects of reaching‐only and reach‐to‐grasp actions calls for a more fine‐grained assessment of the reaching–grasping network in humans by exploiting pattern decoding methods (multivoxel pattern analysis—MVPA).MethodsHere, we used MPVA on functional magnetic resonance imaging (fMRI) data to assess whether regions of the frontoparietal network discriminate between reaching‐only and reach‐to‐grasp actions, natural and constrained grasping, different grasp types, and object sizes. Participants were required to perform either reaching‐only movements or two reach‐to‐grasp types (precision or whole hand grasp) upon spherical objects of different sizes.ResultsMultivoxel pattern analysis highlighted that, independently from the object size, all the selected regions of both hemispheres contribute in coding for grasp type, with the exception of SPOC and the right hAIP. Consistent with recent neurophysiological findings on monkeys, there was no evidence for a clear‐cut distinction between a dorsomedial and a dorsolateral pathway that would be specialized for reaching‐only and reach‐to‐grasp actions, respectively. Nevertheless, the comparison of decoding accuracy across brain areas highlighted their different contributions to reaching‐only and grasping actions.ConclusionsAltogether, our findings enrich the current knowledge regarding the functional role of key brain areas involved in the cortical control of reaching‐only and reach‐to‐grasp actions in humans, by revealing novel fine‐grained distinctions among action types within a wide frontoparietal network.

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Brain activity is similar during precision and power gripping with light force: An fMRI study

Cited by 83 publications

References 59 publications

Cerebellar lobules and dentate nuclei mirror cortical force‐related‐BOLD responses: Beyond all (linear) expectations

Cerebellar lobules and dentate nuclei mirror cortical force‐related‐BOLD responses: Beyond all (linear) expectations

Terahertz time‐domain spectroscopy of poly‐L‐lysine

Probing the reaching–grasping network in humans through multivoxel pattern decoding

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