Brain activity elicited by viewing pictures of the own virtually amputated body predicts xenomelia

Oddo-Sommerfeld, S; Hänggi, Jürgen; Coletta, Ludovico; Skoruppa, S.; Thiel, Aylin; Stirn, Aglaja

doi:10.1016/j.neuropsychologia.2017.11.025

Cited by 23 publications

(34 citation statements)

References 49 publications

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“…In line with the idea of a right posterior parietal involvement in disorders of body ownership, we further investigated whether neuromodulation of these parietal areas might alter the illusion in a systematic way. Brain imaging studies in individuals with Xenomelia have reported altered neural processes in the superior and inferior parietal lobe (Hilti et al, 2013;McGeoch et al, 2011;Oddo-Sommerfeld et al, 2018) at least partly overlapping with the network described by Gentile and colleagues (2013). Limb misidentification due to right-hemispheric damage has also been associated with parietal areas (Antoniello and Gottesman, 2017;Vallar and Ronchi, 2009).…”

Section: Introductionsupporting

confidence: 55%

Experimentally induced limb-disownership in mixed reality

et al. 2019

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The seemingly stable construct of our bodily self depends on the continued, successful integration of multisensory feedback about our body, rather than its purely physical composition. Accordingly, pathological disruption of such neural processing is linked to striking alterations of the bodily self, ranging from limb misidentification to disownership, and even the desire to amputate a healthy limb. While previous embodiment research has relied on experimental setups using supernumerary limbs in variants of the Rubber Hand Illusion, we here used Mixed Reality to directly manipulate the feeling of ownership for one's own, biological limb. Using a Head-Mounted Display, participants received visual feedback about their own arm, from an embodied first-person perspective. In a series of three studies, in independent cohorts, we altered embodiment by providing visuotactile feedback that could be synchronous (control condition) or asynchronous (400ms delay, Real Hand Illusion). During the illusion, participants reported a significant decrease in ownership of their own limb, along with a lowered sense of agency. Supporting the right-parietal body network, we found an increased illusion strength for the left upper limb as well as a modulation of the feeling of ownership during anodal transcranial direct current stimulation. Extending previous research, these findings demonstrate that a controlled, visuotactile conflict about one's own limb can be used to directly and systematically modulate ownershipwithout a proxy. This not only corroborates the malleability of body representation but questions its permanence. These findings warrant further exploration of combined VR and neuromodulation therapies for disorders of the bodily self.

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Section: Introductionsupporting

confidence: 55%

Experimentally induced limb-disownership in mixed reality

et al. 2019

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“…Individuals with this condition, particularly those who desire amputation of a limb, describe themselves as "overcomplete" and as though the limb does not belong to them, experiencing a sense of (non-delusional) disownership over the body part. While research is scant on this subject, it has been growing in recent years [3][4][5][6][7]. The condition manifests before adolescence, usually affects males, and the desire to amputate/paralyze is usually directed towards the lower limbs [2,8].…”

Section: Introductionmentioning

confidence: 99%

Mental rotation of feet in individuals with Body Integrity Identity Disorder, lower-limb amputees, and normally-limbed controls

Stone¹,

Dijkerman²,

Bekrater-Bodmann³

et al. 2019

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Body Integrity Identity Disorder (BIID) is a non-psychotic condition wherein individuals desire amputation or paralysis of one or more healthy, fully-functioning limbs (predominantly the legs). Individuals with BIID have been suggested to have a mismatch between the perceived mental representation of the body and its actual physical structure, such that their desired identity matches that of a lower-limb amputee. Accordingly, studies have reported an altered central network involving body representation of the legs in BIID, but its relationship to behavior remains unclear. In the present study, we investigated the integrity of body representation in individuals with BIID, acquired lower-limb amputees, and normally-limbed controls using an online mental rotation task. Participants judged the laterality of left and right foot images presented from different views, orientations, and of different types. We expected BIID participants to be slower for mentally rotating images that corresponded to their affected legs than lower-limb amputees and normally-limbed participants. We found that groups did not significantly differ in their performance. All participants were slower at judging feet presented in awkward postures than natural postures, replicating previous studies and validating our online paradigm. The results are discussed in terms of the robust nature of visual and sensorimotor lower-limb representations, whether related to the self or as prototype, in the context of disturbed lower-limb integrity.

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“…In line with the idea of a right posterior parietal contribution to disorders of body ownership, we further investigated whether neuromodulation of parietal areas might alter the illusion in a systematic way. Brain imaging studies in individuals with Xenomelia have reported altered neural processes in the superior and inferior parietal lobe (Hilti et al, 2013;McGeoch et al, 2011;Oddo-Sommerfeld et al, 2018). Limb misidentification due to righthemispheric damage has also been associated with parietal areas (Antoniello & Gottesman, 2017;Vallar & Ronchi, 2009).…”

Section: Introductionmentioning

confidence: 99%