Brain activity during auditory and visual phonological, spatial and simple discrimination tasks

Salo, Emma; Rinne, Teemu; Salonen, Oili; Alho, Kimmo

doi:10.1016/j.brainres.2012.12.013

Cited by 27 publications

(55 citation statements)

References 52 publications

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“…Bradshaw and Nettleton, 1981;Cattaneo et al, 2008Cattaneo et al, , 2009Callan et al, 2005;Salo et al, 2013;see Minagawa-Kawai et al (2011) for review). Although visual processing of linguistic and non-linguistic forms share some brain areas, letter and words are also underpinned by brain areas different from non-linguistic stimuli (e.g.…”

Section: Discussionmentioning

confidence: 96%

“…Related to the findings, a functional magnetic resonance imaging (fMRI) study by Callan et al (2005) reported that activation of the left PPC is associated with processing visual shapes as letters when the visual forms carried phonological information. Meanwhile, a given auditory or visual stimulus, e.g., a letter presented in acoustic or visual form, elicited left PPC activation when the task was to discriminate phonological information but not when the task was to discriminate its non-linguistic attributes (Salo et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Repetitive transcranial magnetic stimulation over the left parietal cortex facilitates visual search for a letter among its mirror images

et al. 2015

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Repetitive transcranial magnetic stimulation over the left parietal cortex facilitates visual search for a letter among its mirror images

et al. 2015

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“…Our previous study showed that, when performed separately, the A Phon and V Phon tasks activate the same area in the left prefrontal cortex involved in phonological processing and that the A Spat and V Spat tasks activate the same area in the right inferior parietal cortex involved in spatial processing (Salo et al, 2013). Thus, we expected to find strong modulation of activity especially in these areas.…”

Section: Introductionmentioning

confidence: 99%

“…This design allowed us to study the functional significance of activations associated with different dual tasks. Our previous study (Salo et al, 2013), using identical stimuli and the same participants as the present study, investigated activations associated with the three auditory component tasks and the three visual component tasks when performed as the only task. To evaluate whether all dual tasks activate some common brain areas, we compared the present dual task data with single task data from our previous study.…”

Section: Introductionmentioning

confidence: 99%

Brain activations during bimodal dual tasks depend on the nature and combination of component tasks

Salo

Rinne

Salonen

et al. 2015

Front. Hum. Neurosci.

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We used functional magnetic resonance imaging to investigate brain activations during nine different dual tasks in which the participants were required to simultaneously attend to concurrent streams of spoken syllables and written letters. They performed a phonological, spatial or “simple” (speaker-gender or font-shade) discrimination task within each modality. We expected to find activations associated specifically with dual tasking especially in the frontal and parietal cortices. However, no brain areas showed systematic dual task enhancements common for all dual tasks. Further analysis revealed that dual tasks including component tasks that were according to Baddeley's model “modality atypical,” that is, the auditory spatial task or the visual phonological task, were not associated with enhanced frontal activity. In contrast, for other dual tasks, activity specifically associated with dual tasking was found in the left or bilateral frontal cortices. Enhanced activation in parietal areas, however, appeared not to be specifically associated with dual tasking per se, but rather with intermodal attention switching. We also expected effects of dual tasking in left frontal supramodal phonological processing areas when both component tasks required phonological processing and in right parietal supramodal spatial processing areas when both tasks required spatial processing. However, no such effects were found during these dual tasks compared with their component tasks performed separately. Taken together, the current results indicate that activations during dual tasks depend in a complex manner on specific demands of component tasks.

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“…The nosological boundaries of typical Alzheimer's disease, PCA and other variant Alzheimer's disease syndromes and the extent to which these syndromes share pathophysiological and neuroanatomical substrates remain to be resolved (Warren et al, 2012;Lehmann et al, 2013). Investigation of non-canonical cognitive and behavioural functions is an important avenue for defining syndrome boundaries and commonalities across the Alzheimer's disease spectrum (Hawkes, 2006;Warren et al, 2012;Witoonpanich et al, 2013): in this regard, auditory spatial processing is an attractive candidate function that engages relevant, distributed brain networks but harnesses a distinct sensory system complementary to the conventionally studied paradigm of vision (Bremmer et al, 2001;Lewald et al, 2002;Cohen, 2009;Salo et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

O5‐05‐05: Auditory spatial processing in Alzheimer's disease

Crutch¹,

Golden²,

Warren³

2012

Alzheimer's & Dementia

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The location and motion of sounds in space are important cues for encoding the auditory world. Spatial processing is a core component of auditory scene analysis, a cognitively demanding function that is vulnerable in Alzheimer's disease. Here we designed a novel neuropsychological battery based on a virtual space paradigm to assess auditory spatial processing in patient cohorts with clinically typical Alzheimer's disease (n = 20) and its major variant syndrome, posterior cortical atrophy (n = 12) in relation to healthy older controls (n = 26). We assessed three dimensions of auditory spatial function: externalized versus non-externalized sound discrimination, moving versus stationary sound discrimination and stationary auditory spatial position discrimination, together with non-spatial auditory and visual spatial control tasks. Neuroanatomical correlates of auditory spatial processing were assessed using voxel-based morphometry. Relative to healthy older controls, both patient groups exhibited impairments in detection of auditory motion, and stationary sound position discrimination. The posterior cortical atrophy group showed greater impairment for auditory motion processing and the processing of a non-spatial control complex auditory property (timbre) than the typical Alzheimer's disease group. Voxel-based morphometry in the patient cohort revealed grey matter correlates of auditory motion detection and spatial position discrimination in right inferior parietal cortex and precuneus, respectively. These findings delineate auditory spatial processing deficits in typical and posterior Alzheimer's disease phenotypes that are related to posterior cortical regions involved in both syndromic variants and modulated by the syndromic profile of brain degeneration. Auditory spatial deficits contribute to impaired spatial awareness in Alzheimer's disease and may constitute a novel perceptual model for probing brain network disintegration across the Alzheimer's disease syndromic spectrum.

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Brain activity during auditory and visual phonological, spatial and simple discrimination tasks

Cited by 27 publications

References 52 publications

Repetitive transcranial magnetic stimulation over the left parietal cortex facilitates visual search for a letter among its mirror images

Repetitive transcranial magnetic stimulation over the left parietal cortex facilitates visual search for a letter among its mirror images

Brain activations during bimodal dual tasks depend on the nature and combination of component tasks

O5‐05‐05: Auditory spatial processing in Alzheimer's disease

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