Brain activation to cues predicting inescapable delay in adolescent Attention Deficit/Hyperactivity Disorder: An fMRI pilot study

Lemiere, Jurgen; Danckaerts, Marina; Hecke, Wim Van; Mehta, Mitul A.; Peeters, Ronald; Sunaert, Stefan; Sonuga‐Barke, Edmund

doi:10.1016/j.brainres.2012.02.027

Cited by 43 publications

(49 citation statements)

References 87 publications

(26 reference statements)

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“…Indeed, striatal structures are known to show biphasic responses, making them capable of responding to positive (reward) as well as negative (punishment) stimulation. 47 Moreover, such an account would be in line with experimental findings demonstrating increased responses in reward processing brain regions to delayed rewards 39 . Yet, both reward magnitude and reward probability are coded relatively rather than absolutely.…”

Section: Discussionsupporting

confidence: 64%

“…Alternatively, they might be unable to correctly establish an association between a reward-predicting cue and the receipt, leading to an increased prediction error response during reward receipt relative to non-reward. A third explanation would be that participants with ADHD experience the inability to gain reward as overly aversive, which may result in a stronger signal of the brain to avoid such a situation in future 39 .…”

Section: Discussionmentioning

confidence: 99%

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Increased Neural Responses to Reward in Adolescents and Young Adults With Attention-Deficit/Hyperactivity Disorder and Their Unaffected Siblings

Rhein

Cools

Zwiers

et al. 2015

Journal of the American Academy of Child & Adolescent Psych

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Objective Attention-deficit/hyperactivity disorder (ADHD) is a heritable neuropsychiatric disorder associated with abnormal reward processing. Limited and inconsistent data exist about the neural mechanisms underlying this abnormality. Furthermore, it is unknown whether reward processing is abnormal in unaffected siblings of participants with ADHD. Method We used event-related functional magnetic resonance imaging (fMRI) to investigate brain responses during reward anticipation and receipt with an adapted monetary incentive delay task in a large sample of adolescents and young adults with ADHD (n=150), their unaffected siblings (n=92), and control participants (n=108), all of the same age. Results Participants with ADHD showed, relative to control participants, increased responses in the anterior cingulate, anterior frontal cortex, and cerebellum during reward anticipation, and in the orbitofrontal, occipital cortex, and ventral striatum during reward receipt. Responses of unaffected siblings were increased in these regions as well, except for the cerebellum during anticipation and the orbitofrontal cortex during receipt. Conclusion ADHD in adolescents and young adults is associated with enhanced neural responses in frontostriatal circuitry to anticipation and receipt of reward. The findings support models emphasizing aberrant reward processing in ADHD and suggest that processing of reward is subject to familial influences. Future studies using standard monetary incentive delay task parameters have to replicate our findings.

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Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Increased Neural Responses to Reward in Adolescents and Young Adults With Attention-Deficit/Hyperactivity Disorder and Their Unaffected Siblings

Rhein

Cools

Zwiers

et al. 2015

Journal of the American Academy of Child & Adolescent Psych

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“…For the sake of completeness, two additional published fMRI studies should be mentioned, although they focused on different aspects of reward/motivational processing (Lemiere et al, 2012; Wilbertz et al, 2012). The study by Wilbertz et al exclusively focused on reward delivery rather than reward anticipation and found no differences in the VS, replicating the finding of Scheres et al (2007).…”

Section: Bold Fmri Studies On Reward Processing In Adhdmentioning

confidence: 99%

Ventral–striatal responsiveness during reward anticipation in ADHD and its relation to trait impulsivity in the healthy population: A meta-analytic review of the fMRI literature

Plichta¹,

Scheres²

2014

Neuroscience & Biobehavioral Reviews

359

302

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A review of the existing functional magnetic resonance imaging (fMRI) studies on reward anticipation in patients with attention-deficit/hyperactivity disorder (ADHD) is provided. Meta-analysis showed a significant medium effect size (Cohen’s d = 0.48–0.58) in terms of ventral–striatal (VS)-hyporesponsiveness in ADHD. Studies on VS-responsiveness and trait impulsivity in the healthy population demonstrate the opposite relationship, i.e. impulsivity-scores positively correlated with VS activation during reward processing. Against the background that ADHD may represent an extreme on a continuum of normal variability, the question arises as to how these contrasting findings can be integrated. We discuss three theoretical approaches, each of which integrates the opposing findings: (1) an inverted-u-shape model; (2) a (genetic) moderator model; and (3) the “unrelated model”. We conclude that at the present stage the number of existing studies in the healthy population as well as in ADHD groups is too small for a final answer. Therefore, our presented integrative approaches should be understood as an attempt to frame future research directions by generating testable hypotheses and giving practical suggestions for future studies.

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“…For example, Plichta and colleagues (2009) identified increased activity in amygdala in adults with ADHD comparing to healthy controls during the choices of delayed rewards. Lemiere et al (2012) found increased insula and amygdala activity during the anticipation of an inescapable delay. Wilbertz and colleagues (2013) reported a positive association between the activity in inferior temporal cortex and right amygdala and the length of delayed period within the ADHD but not the control group.…”

Section: Discussionmentioning

confidence: 90%

“…delay aversion; Sonuga-Barke, 2002) mediated by hyper-activation within the brain's emotion centres (e.g. insula and amygdala; Lemiere et al, 2012;Plichta et al, 2009;Wilbertz et al, 2013). Interestingly, the potential role of intrinsic brain activity during the process of waiting in individuals with ADHD has not been investigated.…”

Section: Introductionmentioning

confidence: 99%

Spontaneous activity in the waiting brain: A marker of impulsive choice in attention-deficit/hyperactivity disorder?

Hsu

Benikos

Sonuga‐Barke

2015

Developmental Cognitive Neuroscience

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Brain activation to cues predicting inescapable delay in adolescent Attention Deficit/Hyperactivity Disorder: An fMRI pilot study

Cited by 43 publications

References 87 publications

Increased Neural Responses to Reward in Adolescents and Young Adults With Attention-Deficit/Hyperactivity Disorder and Their Unaffected Siblings

Increased Neural Responses to Reward in Adolescents and Young Adults With Attention-Deficit/Hyperactivity Disorder and Their Unaffected Siblings

Ventral–striatal responsiveness during reward anticipation in ADHD and its relation to trait impulsivity in the healthy population: A meta-analytic review of the fMRI literature

Spontaneous activity in the waiting brain: A marker of impulsive choice in attention-deficit/hyperactivity disorder?

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