Brain activation induced by psychological stress in patients with schizophrenia

Castro, Mariana N.; Villarreal, Mirta F.; Bolotinsky, N.; Papávero, E.; Goldschmidt, Micaela; Costanzo, Elsa Y.; Drucaroff, Lucas; Wainsztein, Agustina; Achával, Delfina de; Pahissa, Jaime; Bär, Karl‐Jürgen; Nemeroff, Charles B.; Guinjoan, Salvador M.

doi:10.1016/j.schres.2015.07.008

Cited by 16 publications

(14 citation statements)

References 63 publications

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“…This view is supported by previous data pointing to protracted autonomic activity in a similar paradigm and sample of individuals [3]. Also, it could be in accordance with previous studies carried out on patients with schizophrenia in both peripheral and central nervous system measures in response to stress [4,5]. In such case, similarities in siblings discordant for schizophrenia suggest a heritable trait of abnormal limbic functioning possibly representing an endophenotype.…”

Section: Discussionsupporting

confidence: 90%

“…Specifically, activation in these limbic areas are triggered by simple tasks and persist during and after stress. This might represent a neurobiological signature of hyperreactivity to normal stressful situations and hypervigilance state characteristic of this disease [5]. In the present study, we observed failure to engage the hippocampus during stress and shortly thereafter, in comparison with rest and a non-stressful mental task.…”

Section: Discussionsupporting

confidence: 57%

“…In the present study we have focused on the involvement of hippocampal formation in psychological stress related to mental arithmetic given the burgeoning evidence of a role of this structure in schizophrenia [38,28,46]. In fact, we previously found a pattern of persisting activation of hippocampus together with other limbic areas in response to stress in patients with schizophrenia [5]. Specifically, activation in these limbic areas are triggered by simple tasks and persist during and after stress.…”

Section: Discussionmentioning

confidence: 91%

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Brain activation induced by psychological stress in nonpsychotic siblings of patients with schizophrenia

Castro

Papávero

Bolotinsky

et al. 2017

Personalized Medicine in Psychiatry

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 91%

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Brain activation induced by psychological stress in nonpsychotic siblings of patients with schizophrenia

Castro

Papávero

Bolotinsky

et al. 2017

Personalized Medicine in Psychiatry

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“…Importantly, because this task will also be administered to clinical populations such as individuals at ‘clinical high-risk’ to develop psychosis in the future, we chose a stress manipulation that did not include negative feedback and could be successfully applied to them. Previous findings highlight that this population perceives even mildly stressful situations (i.e., solving simple mathematical problems with feedback introduced as a ‘neutral’ block) as extremely stressful [ 93 ], essentially equating them with the ‘stress’ block. Furthermore, based on our previous experience with clinical high-risk individuals in experimental settings in which participants were given negative feedback, we sought a mild stress manipulation that would ensure that they would complete the experiment and not leave due to the feedback.…”

Section: Methodsmentioning

confidence: 99%

Assessing the Relationship between Sense of Agency, the Bodily-Self and Stress: Four Virtual-Reality Experiments in Healthy Individuals

Stern

Koren

Moebus

et al. 2020

JCM

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The bodily-self, our experience of being a body, arises from the interaction of several processes. For example, embodied Sense of Agency (SoA), the feeling of controlling our body’s actions, is a fundamental facet of the bodily-self. SoA is disturbed in psychosis, with stress promoting its inception. However, there is little knowledge regarding the relationship between SoA, stress, and other facets of the bodily-self. In four experiments manipulating embodied SoA using a virtual hand (VH), we examined (1) How is embodied SoA related to other facets of the bodily-self?; and (2) How is SoA impacted by stress? We found that increased alteration of the VH significantly decreased subjective ratings of SoA and body ownership (Exp. 1), supporting the close relation between SoA and body ownership. Interoceptive accuracy and SoA were positively correlated (Exp. 3), connecting awareness to one’s actions and cardiac signals. Contrary to our expectations, SoA was not related to trait anxiety (Exp. 3), nor did induced stress impair SoA (Exp. 4). Finally, we found a negative correlation between self-reported prodromal symptoms and SoA. These results strongly support the connection between SoA and the bodily-self. Whereas, SoA was not impaired by stress, and weakly related to psychotic symptoms.

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“…Effects of sleep deprivation on PSI subscales independent from time of day (morning/evening measures) were found only when sleep deprivation was the first testing session. Thus, there might be additional influences of, for example, stress or anxiety due to the unfamiliar situation, that may have increased psychosis-like experiences similar to findings of deterioration of psychotic symptoms under stress in schizophrenia patients (Castro et al, 2015). Therefore, additional studies might profit from a between-subjects design.…”

Section: Limitationsmentioning

confidence: 99%

Sleep deprivation as an experimental model system for psychosis: Effects on smooth pursuit, prosaccades, and antisaccades

et al. 2016

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Current antipsychotic medications fail to satisfactorily reduce negative and cognitive symptoms and produce many unwanted side effects, necessitating the development of new compounds. Cross-species, experimental behavioural model systems can be valuable to inform the development of such drugs. The aim of the current study was to further test the hypothesis that controlled sleep deprivation is a safe and effective model system for psychosis when combined with oculomotor biomarkers of schizophrenia. Using a randomized counterbalanced within-subjects design, we investigated the effects of 1 night of total sleep deprivation in 32 healthy participants on smooth pursuit eye movements (SPEM), prosaccades (PS), antisaccades (AS), and self-ratings of psychosis-like states. Compared with a normal sleep control night, sleep deprivation was associated with reduced SPEM velocity gain, higher saccadic frequency at 0.2 Hz, elevated PS spatial error, and an increase in AS direction errors. Sleep deprivation also increased intra-individual variability of SPEM, PS, and AS measures. In addition, sleep deprivation induced psychosis-like experiences mimicking hallucinations, cognitive disorganization, and negative symptoms, which in turn had moderate associations with AS direction errors. Taken together, sleep deprivation resulted in psychosis-like impairments in SPEM and AS performance. However, diverging somewhat from the schizophrenia literature, sleep deprivation additionally disrupted PS control. Sleep deprivation thus represents a promising but possibly unspecific experimental model that may be helpful to further improve our understanding of the underlying mechanisms in the pathophysiology of psychosis and aid the development of antipsychotic and pro-cognitive drugs.

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Brain activation induced by psychological stress in patients with schizophrenia

Cited by 16 publications

References 63 publications

Brain activation induced by psychological stress in nonpsychotic siblings of patients with schizophrenia

Brain activation induced by psychological stress in nonpsychotic siblings of patients with schizophrenia

Assessing the Relationship between Sense of Agency, the Bodily-Self and Stress: Four Virtual-Reality Experiments in Healthy Individuals

Sleep deprivation as an experimental model system for psychosis: Effects on smooth pursuit, prosaccades, and antisaccades

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