Brain activation in response to bladder filling and simultaneous stimulation of the dorsal clitoral nerve—An fMRI study in healthy women

Mehnert, Ulrich; Boy, Sönke; Svensson, Jonas; Michels, Lars; Reitz, André; Candia, Victor; Kleiser, Raimund; Kollias, Spyros; Schurch, Brigitte

doi:10.1016/j.neuroimage.2008.03.006

Cited by 58 publications

(64 citation statements)

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“…27 Ascending pathways connect with structures in the brainstem, including the pons and periaqueductal gray matter of the midbrain to execute reflex functions, and with higher centers of the brain (cingulate and frontal gyri) mediating storage and conscious perception of sensations arising from the LUT. 28 Activation of the sympathetic circuits through spinal reflexes mediates detrusor muscle relaxation and bladder neck contraction, resulting in storage of urine. Activation of the sacral parasympathetic efferents results in detrusor contraction and promotes voiding.…”

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confidence: 99%

International standards to document remaining autonomic function after spinal cord injury

et al. 2008

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Study design: Experts opinions consensus.Objective: To develop a common strategy to document remaining autonomic neurologic function following spinal cord injury (SCI). Background and Rationale: The impact of a specific SCI on a person's neurologic function is generally described through use of the International Standards for the Neurological Classification of SCI. These standards document the remaining motor and sensory function that a person may have; however, they do not provide information about the status of a person's autonomic function. Methods: Based on this deficiency, the American Spinal Injury Association (ASIA) and the International Spinal Cord Society (ISCoS) commissioned a group of international experts to develop a common strategy to document the remaining autonomic neurologic function. Results: Four subgroups were commissioned: bladder, bowel, sexual function and general autonomic function. On-line communication was followed by numerous face to face meetings. The information was then presented in a summary format at a course on Measurement in Spinal Cord Injury, held on June 24, 2006. Subsequent to this it was revised online by the committee members, posted on the websites of both ASIA and ISCoS for comment and re-revised through webcasts. Topics include an overview of autonomic anatomy, classification of cardiovascular, respiratory, sudomotor and thermoregulatory function, bladder, bowel and sexual function. Conclusion: This document describes a new system to document the impact of SCI on autonomic function. Based upon current knowledge of the neuroanatomy of autonomic function this paper provides a framework with which to communicate the effects of specific spinal cord injuries on cardiovascular, broncho-pulmonary, sudomotor, bladder, bowel and sexual function.

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confidence: 99%

International standards to document remaining autonomic function after spinal cord injury

et al. 2008

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“…Here the focus has generally been on nociceptive inputs to the insula. While visceral inputs to the insula are strong and important (e.g., Critchley et al, 2004;Mehnert et al, 2008;Wang et al, 2008), most research has focussed on tactile and thermal inputs (e.g., Craig, Chen, Bandy, & Reiman, 2000;Olausson et al, 2002), which are methodologically easier to study. Craig (2009), reviewing a wide range of human studies, noted that anterior insular activation is repeatedly associated with awareness of one's own body in general, and with awareness of the emotional significance of bodily events in particular.…”

Section: Body Beyond Si 24mentioning

confidence: 99%

More than skin deep: Body representation beyond primary somatosensory cortex

2010

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The neural circuits underlying initial sensory processing of somatic information are relatively well understood. In contrast, the processes that go beyond primary somatosensation to create more abstract representations related to the body are less clear. In this review, we focus on two classes of higher-order processing beyond somatosensation. Somatoperception refers to the process of perceiving the body itself, and particularly of ensuring somatic perceptual constancy.We review three key elements of somatoperception: (a) remapping information from the body surface into an egocentric reference frame (b) exteroceptive perception of objects in the external world through their contact with the body and (c) interoceptive percepts about the nature and state of the body itself. Somatorepresentation, in contrast, refers to the essentially cognitive process of constructing semantic knowledge and attitudes about the body, including: (d) lexicalsemantic knowledge about bodies generally and one's own body specifically, (e) configural knowledge about the structure of bodies, (f) emotions and attitudes directed towards one's own body, and (g) the link between physical body and psychological self. We review a wide range of neuropsychological, neuroimaging and neurophysiological data to explore the dissociation between these different aspects of higher somatosensory function.Body Beyond SI 3

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“…Although the stimulation sites are different and the exact mechanism of action remains to be elucidated, the modulation of spinal cord-mediated reflexes through interneurons and brain networks by peripheral afferents seem to be involved [33]. Indeed, dorsal clitoral nerve stimulation during bladder filling in healthy women reduced the activation of certain cortical areas suggesting a neuromodulation effect on supraspinal centres relevant for lower urinary tract control [34]. However, there is a complete lack of literature about the mechanism of action of TENS for treating NLUTD so appropriately designed studies are highly warranted.…”

Section: Findings In the Context Of Existing Evidencementioning

confidence: 99%

Transcutaneous Electrical Nerve Stimulation for Treating Neurogenic Lower Urinary Tract Dysfunction: A Systematic Review

et al. 2016

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Brain activation in response to bladder filling and simultaneous stimulation of the dorsal clitoral nerve—An fMRI study in healthy women

Abstract: Simultaneous dorsal clitoral nerve stimulation during bladder filling reduced the activation of certain cortical areas suggesting a neuromodulatory effect of this stimulation on supraspinal centres involved in lower urinary tract control.

Cited by 58 publications

References 50 publications

International standards to document remaining autonomic function after spinal cord injury

International standards to document remaining autonomic function after spinal cord injury

More than skin deep: Body representation beyond primary somatosensory cortex

Transcutaneous Electrical Nerve Stimulation for Treating Neurogenic Lower Urinary Tract Dysfunction: A Systematic Review

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